Theranostic Approach for Pancreatic Cancer
Theranostic Approach for Pancreatic Cancer

Author: Ganji Purnachandra Nagaraju

Publisher: Academic Press

Published: 2020-01-15

Total Pages: 420

ISBN-13: 9780128194577

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Theranostic Approach for Pancreatic Cancer modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property through introducing new strategies and drugs for tackling the disease. It brings information about ongoing research as well as clinical data about pancreatic cancer and provides detailed descriptions about diagnostic and therapeutic options for easy understanding. This book discusses several topics related to pancreatic cancer such as stem cells, drug resistance and pancreatic tumor microenvironment, the latest developments in chemotherapy for metastatic cancer and chemoprevention, and epigenome as a therapeutic strategy. Additionally, it encompasses a discussion on theranostic clinical applications for personalized treatment and management of pancreatic cancer. The book is a valuable resource for cancer researchers, oncologists, and several members of the biomedical field who need to understand more about the diagnosis and treatment of pancreatic cancer. Provides information on the roadblocks of chemotherapy in patients with newly diagnosed and metastatic pancreatic cancer Discusses treatment options available currently as well as prospective options for the future Focuses especially on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways as already tested types of treatment

Translational Pancreatic Cancer Research
Translational Pancreatic Cancer Research

Author: Christoph W. Michalski

Publisher: Springer Nature

Published: 2020-07-31

Total Pages: 252

ISBN-13: 3030494764

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​This book incorporates a multi-disciplinary approach to present how research results can be translated into clinical trials. The first part begins with a chapter on variants of pancreatic cancer, precursor lesions and groups of people at risk to developing the disease. There is a particular focus on intraductal papillary mucinous neoplasia as a large-scale clinical challenge in pancreatology. The next two parts focus on diagnosis, biomarkers and stratification that emphasize how various approaches to biomarker development are important as both prognostic and predictive tools. The final part consists of personalized treatment approaches that include preclinical models of pancreatic cancer and stromal, epigenetic and metabolism targeting as promising approaches to be translated into early phase clinical trials. Chapters within this part also deal with approaches that are close to being implemented in clinical practice or are already being tested in (early) clinical trials, such as those that targeting the immune systems and strategies to overcome immunotherapy resistance; phase 1 clinical trials and translational approaches in surgical treatment. Written by experts in their fields, Translational Pancreatic Cancer Research provides an outlook towards future directions by integrating information both from basic and clinical research and though demonstrating pathways to better understanding pancreatic cancer and current approaches to translating these into clinical practice.

Homelessness, Health, and Human Needs
Homelessness, Health, and Human Needs

Author: Institute of Medicine

Publisher: National Academies Press

Published: 1988-02-01

Total Pages: 257

ISBN-13: 0309038324

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There have always been homeless people in the United States, but their plight has only recently stirred widespread public reaction and concern. Part of this new recognition stems from the problem's prevalence: the number of homeless individuals, while hard to pin down exactly, is rising. In light of this, Congress asked the Institute of Medicine to find out whether existing health care programs were ignoring the homeless or delivering care to them inefficiently. This book is the report prepared by a committee of experts who examined these problems through visits to city slums and impoverished rural areas, and through an analysis of papers written by leading scholars in the field.

Clinical Pancreatology for Practising Gastroenterologists and Surgeons
Clinical Pancreatology for Practising Gastroenterologists and Surgeons

Author: Juan Enrique Dominguez-Munoz

Publisher: John Wiley & Sons

Published: 2021-03-17

Total Pages: 752

ISBN-13: 111957014X

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Clinical Pancreatology Since the book Clinical Pancreatology for Practising Gastroenterologists and Surgeons was first published sixteen years ago, the knowledge and clinical management of pancreatic diseases have developed markedly. Thanks to the development of the translational research and the from bench to bedside concept, much progress from the lab has been applied to clinical practice. In addition, several highly relevant clinical trials published over the last years have resulted in the update and optimisation of clinical guidelines. A new and validated classification of severity and complications of acute pancreatitis is firmly rooted in clinical practice and has been the basis for the development of minimally invasive approaches to pancreatic necrosis. The etiopathogenic knowledge of chronic pancreatitis and other pancreatopaties, like that associated with diabetes mellitus, has developed significantly. Especially important has been the development of the field of cystic pancreatic tumours, which has been reflected in the publication of several guidelines and consensus reports over the last few years. Most research efforts have focused on pancreatic cancer, which have led and will further lead to a significant increase in the therapeutic armamentarium against this devastating disease. Finally, many newly published studies have changed the concept, causes, clinical relevance, diagnosis and treatment of exocrine pancreatic insufficiency. This new edition of Clinical Pancreatology for Practising Gastroenterologists and Surgeons has enjoyed the collaboration of the world’s leading experts in each of the areas of clinical pancreatology with the aim of facilitating gastroenterologists, surgeons, oncologists, internists, nutritionists, diabetologists, paediatricians, radiologists, pathologists and other specialists in their decision making when facing patients with pancreatic diseases in their daily clinical practice. All in all, this book supplies an indispensable update of the relevant aspects of clinical pancreatology.

Challenges in Pancreatic Cancer
Challenges in Pancreatic Cancer

Author: Borislav Vladimirov

Publisher: BoD – Books on Demand

Published: 2021-12-22

Total Pages: 115

ISBN-13: 1839629584

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Pancreatic cancer is one of the most lethal solid organ tumors with a poor five-year survival rate despite current oncological advances. The early and proper diagnosis of pancreatic cancer is of great importance for the improvement of the overall prognosis. This book provides an overview of the current challenges and states of pancreatic cancer and pancreatic neuroendocrine tumors, including information on diagnostic tools, treatment strategies, and mechanisms of pancreatic cancer therapy resistance.

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy
Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy

Author:

Publisher: Academic Press

Published: 2019-02-26

Total Pages: 226

ISBN-13: 0128176628

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Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy edited by Dr. Nagaraju, PhD., DSc. focuses on overriding the resistance from chemotherapeutic drugs with a broader range of treatment options. It particularly focuses on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways. This volume discusses topics such as pancreatic cancer biology, current therapeutic options, EMT, chemotherapy resistance mechanisms, and genetic manipulations and natural products to enhance the sensitivity of pancreatic cancer to chemotherapy. Additionally, it discusses small targeted molecules and pancreatic cancer trials, and nanotechnology-based drug delivery. Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy is a valuable source for researchers and advanced students in cancer and oncology as well as clinicians and medical students who are interested in learning more about ways to break pancreatic cancer resistance to chemotherapy. - Modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property by introducing new strategies and drugs - Provides information about on-going research as well as clinical data on pancreatic cancer and detailed descriptions about therapeutic options for easy understanding - Utilizes full color figures to help the understanding of the content and tables for easy comparison of information as well as quick access to it

Toward Precision Medicine
Toward Precision Medicine

Author: National Research Council

Publisher: National Academies Press

Published: 2012-01-16

Total Pages: 142

ISBN-13: 0309222222

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Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

Pancreatic Cancer
Pancreatic Cancer

Author: Douglas B. Evans

Publisher: Springer Science & Business Media

Published: 2002

Total Pages: 413

ISBN-13: 0387951857

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The MD Anderson Solid Tumor Oncology series presents cutting-edge surgical treatment and medical therapy for specific sites. This volume, Pancreatic Cancer, addresses epidemiology and molecular biology, inherited syndromes, staging, surgical techniques, multimodality therapy, and emerging therapies. The individual chapters focus on narrow, specific topics to produce a reference work of value to those interested in pancreatic cancer from a clinical and translational research perspective. A must-have for surgical oncologists and general surgeons.

Surgical Diseases of the Pancreas and Biliary Tree
Surgical Diseases of the Pancreas and Biliary Tree

Author: Savio George Barreto

Publisher:

Published: 2018

Total Pages:

ISBN-13: 9789811087561

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This book provides an evidence-based approach to the diagnosis and surgical management of the diseases of the pancreas and biliary tree, highlighting the most recent findings. The chapters are designed to accompany the reader on a step-by-step approach to the patient, providing the latest evidence to justify each recommendation. Wherever feasible and indicated, emphasis is placed on the use of tables and algorithms to simplify decision-making. The information contained in this well-referenced book is thus relevant not only to practicing pancreatobiliary and general surgeons, but also offers valuable guidance for surgical trainees. This book covers 14 diseases of the pancreas and biliary tree, from the more common gallstones and common bile duct stones, acute and chronic pancreatitis, to more complex benign conditions such as biliary fistulae and strictures, as well as cystic tumors of the pancreas, and finally the major malignancies include gallbladder cancer, pancreatic cancer and hilar cholangiocarcinoma. .