Cellular Stress Responses in Renal Diseases
Cellular Stress Responses in Renal Diseases

Author: Mohammed S. Razzaque

Publisher: Karger Medical and Scientific Publishers

Published: 2005-01-01

Total Pages: 167

ISBN-13: 380557858X

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Heat shock proteins are a distinctive class of proteins that have evolved to cope with stress and to provide cellular defense against a wide range of cell injuries. Cellular stress responses include a transient rearrangement of functional activities in order to protect and maintain essential cellular functions. The science of stress responses in various renal diseases is a new and still evolving medical discipline which offers the prospect of new alternate therapeutic options. This publication provides basic information about the important role of stress proteins in several renal diseases, ranging from hypoxic injuries to fibrotic renal disorders and tumors. Each chapter is written in a clear but concise style and includes illustrations necessary to highlight essential biological pathways which have been discovered during the past few years. Providing an overview of contemporary issues, this book will be a useful reference book for clinicians and basic researchers in the fields of cell biology, pathology and nephrology who are either involved in dealing with patients suffering from various renal diseases or in defining various stress responses during tissue injury and subsequent organ damage.

Membrane Dynamics and Calcium Signaling
Membrane Dynamics and Calcium Signaling

Author: Joachim Krebs

Publisher: Springer

Published: 2018-03-28

Total Pages: 409

ISBN-13: 3319558587

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This book describes the newest discoveries on calcium signaling happening at the cellular and intracellular membranes, often exerted in so called microdomains. Calcium entry and release, its interaction with proteins and resulting events on proteins and organelles are comprehensively depicted by leading experts in the field. Knowledge about details of these highly dynamic processes rapidly increased in recent years, the book therefore provides a timely summary on the processes of calcium signaling and related membrane dynamics; it is aimed at students and researchers in biochemistry and cell biology.

Diseases of the Kidney and Urinary Tract
Diseases of the Kidney and Urinary Tract

Author: Robert W. Schrier

Publisher: Lippincott Williams & Wilkins

Published: 2007

Total Pages: 1026

ISBN-13: 9780781793070

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The thoroughly updated Eighth Edition of this classic three-volume work provides the most comprehensive, current, and authoritative information on diseases of the kidney and urinary tract. This clinically oriented reference focuses on diagnosis and treatment of specific diseases, disorders, and complications and incorporates the basic science practicing physicians need to evaluate and manage the disease process. Each of the fourteen sections is written by internationally renowned contributors and provides coverage comparable to a complete book. The first two sections review renal basic science and describe current diagnostic tools. The remaining twelve sections cover various types of diseases, including hypertension, urological problems, and urinary tract concerns. Each disease-oriented section begins with an up-to-date review of pathophysiology and then focuses on specific diseases. This edition has new lead authors for more than 25 chapters, and separate chapters on heart disease and the kidney, liver disease and the kidney, and the nephrotic syndrome.

Uremic Toxins
Uremic Toxins

Author: Severin Ringoir

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 292

ISBN-13: 1468454455

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The present book contains the Proceedings of a two day Symposium on Uremic Toxins organized at the University of Ghent in Belgium. A series of guest lectures, free communications and posters have been presented. An international audience of 163 scientists from 16 nationalities listened to and discussed extensively a spectrum of topics brought forward by colleagues and researchers who worked for many years in the field of Uremic Toxins. There is a striking contrast between all the new dialysis strategies available in the work to "clean" the uremic patients and the almost non-progression of our knowledge on uremic toxins in the past decade. In this sense the symposium was felt by all participants as a new start for the research in the biochemical field of the definition of uremia. If the present volume would stimulate new work in this field in order to define uremia, or identify the uremic toxins, the purpose of the organizers would be maximally fulfilled.

Podocytopathy
Podocytopathy

Author: Z.-H. Liui

Publisher: Karger Medical and Scientific Publishers

Published: 2014-05-16

Total Pages: 274

ISBN-13: 3318026514

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The podocyte is a key cell that forms the last barrier of the kidney filtration unit. One of the most exciting developments in the field of nephrology in the last decade has been the elucidation of its biology and its role in the pathophysiology of inherited and acquired glomerular disease, termed podocytopathy. In this publication, world-renowned experts summarize the most recent findings and advances in the field: they describe the unique biological features and injury mechanisms of the podocyte, novel techniques used in their study, and diagnosis and potential therapeutic approaches to glomerular diseases. Due to its broad scope, this publication is of great value not only for clinical nephrologists and researchers, but also for students, residents, fellows, and postdocs.

Biology of Stress in Fish
Biology of Stress in Fish

Author: Carl B. Schreck

Publisher: Academic Press

Published: 2016-11-01

Total Pages: 604

ISBN-13: 0128027371

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Biology of Stress in Fish: Fish Physiology provides a general understanding on the topic of stress biology, including most of the recent advances in the field. The book starts with a general discussion of stress, providing answers to issues such as its definition, the nature of the physiological stress response, and the factors that affect the stress response. It also considers the biotic and abiotic factors that cause variation in the stress response, how the stress response is generated and controlled, its effect on physiological and organismic function and performance, and applied assessment of stress, animal welfare, and stress as related to model species. - Provides the definitive reference on stress in fish as written by world-renowned experts in the field - Includes the most recent advances and up-to-date thinking about the causes of stress in fish, their implications, and how to minimize the negative effects - Considers the biotic and abiotic factors that cause variation in the stress response

Protein Misfolding
Protein Misfolding

Author: Rossen Donev

Publisher: Academic Press

Published: 2020-01-13

Total Pages: 450

ISBN-13: 0128177500

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Protein Misfolding, Volume 118, covers the wide spectrum of diseases and disorders that are attributed to protein misfolding, including degenerative and neurodegenerative, cardiovascular, renal, glaucoma, cancer, cystic fibrosis, Gaucher's disease, and many others. Specific chapters cover Mass spectrometric approaches for profiling protein folding and stability, Biomembranes, a key player in protein misfolding, how Genetic and environmental factors interact to disrupt proteostasis and trigger protein misfolding diseases, Formation of oligomers and large amorphous aggregates by intrinsically disordered proteins, Protein misfolding in ER stress with applications to cardiovascular and renal disease, and much more.

Oxidative Stress and Chronic Degenerative Diseases
Oxidative Stress and Chronic Degenerative Diseases

Author: Jose Antonio Morales-Gonzalez

Publisher: BoD – Books on Demand

Published: 2013-05-22

Total Pages: 516

ISBN-13: 953511123X

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This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Oxidative Stress and Chronic Degenerative Diseases - a Role for Antioxidants is written for health professionals by researchers at diverse educative institutions (Mexico, Brazil, USA, Spain, Australia, and Slovenia). I would like to underscore that of the 19 chapters, 14 are by Mexican researchers, which demonstrates the commitment of Mexican institutions to academic life and to the prevention and treatment of chronic degenerative diseases.

DNA Sensors and Inflammasomes
DNA Sensors and Inflammasomes

Author:

Publisher: Academic Press

Published: 2019-08-25

Total Pages: 370

ISBN-13: 0128183608

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DNA Sensors and Inflammasomes, Volume 625, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. New sections in this release include Phosphorylation and dimerization of STING and IRF3, cGAS enzymology, Synthesis and identification of immuno-stimulatory CDNs, Tracking cGAS activity/ cGAMP formation using SPR/NMR, Using an enzyme coupled assay to track cGAS activity under steady states, Tracking the polymerization of DNA sensors, inflammasome receptors, and downstream signaling partners using FRET, NLRC4 structure, Tracking TREX1 activity, DNA association and dissociation kinetics of PARP1, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Methods in Enzymology series - Includes the latest information on DNA sensors and inflammasomes

Novel Prospects in Oxidative and Nitrosative Stress
Novel Prospects in Oxidative and Nitrosative Stress

Author: Pinar Atukeren

Publisher: BoD – Books on Demand

Published: 2018-05-09

Total Pages: 158

ISBN-13: 1789230861

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Oxidative stress plays a crucial role in the pathophysiology of various diseases when there is a disruption of the intracellular redox balance and the homeostatic balance between cellular oxidants and antioxidants. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) react with molecular targets including proteins, lipids, and nucleic acids contributing to mitochondrial injury and cellular dysfunction. This book intends to provide the readers with an extensive overview of the novel approaches and prospects based on oxidative and nitrosative stress in the pathophysiology of various diseases and in the current treatment strategies with antioxidants.