Cellular domains play vital roles in a wide range of cellular functions. Defining cellular domains and understanding the molecular basis of their formation is essential to the study of cell functionality. This authoritative reference provides the most comprehensive analysis available on cellular domains, with emphasis on the definition and molecular composition of the domain as well as the functional implications of domain organization.
Helicases are ubiquitous enzymes found throughout evolution. Research in the helicase field has been going on for a long time now but in recent past with the completion of so many genomes, these enzymes have been discovered in a number of organisms. But the available literature is scattered. The huge number of identified DNA and RNA helicases, along with the structural and functional differences among them, make difficult for the interested scholar to grasp a comprehensive view of the field. Helicases from all Domains of Life is the first book to compile information about helicases from many different organisms in one place. Knowledge of the functions and features of helicases across the different kingdoms of life are a valuable source of novel ideas and information The book begins with a chapter on the evolutionary history of helicases followed by three "overview" chapters: one for bacteria/archaea (which are not mentioned), one for plants/algae and one for human helicases The overview chapters are followed by specific chapters on selected helicases of great importance from a biological/applicative point of view
Wavelets have emerged as an important tool in analyzing functions containing discontinuities and sharp spikes. They were developed independently in the fields of mathematics, quantum physics, electrical engineering, and seismic geology. Interchanges between these fields during the last ten years have led to many new wavelet applications such as image compression, turbulence, human vision, radar, earthquake prediction, and pure mathematics applications such as solving partial differential equations. This book develops a theory of wavelet bases and wavelet frames for function spaces on various types of domains. Starting with the usual spaces on Euclidean spaces and their periodic counterparts, the exposition moves on to so-called thick domains (including Lipschitz domains and snowflake domains). Specifically, wavelet expansions and extensions to corresponding spaces on Euclidean $n$-spaces are developed. Finally, spaces on smooth and cellular domains and related manifolds are treated. Although the presentation relies on the recent theory of function spaces, basic notation and classical results are repeated in order to make the text self-contained. This book is addressed to two types of readers: researchers in the theory of function spaces who are interested in wavelets as new effective building blocks for functions and scientists who wish to use wavelet bases in classical function spaces for various applications. Adapted to the second type of reader, the preface contains a guide on where to find basic definitions and key assertions.
A textbook for undergraduate and graduate students in structural biology, chemistry, biochemistry, biology and medicine. It covers various aspects of proteins, nucleic acids and lipids, including the rise and fall of proteins, membranes and gradients, the structural biology of cells, and evolution - the comparative structural biology.
Receptors of Inflammatory Cells: Structure-Function Relationships is the first in a new serial on Cellular and Molecular Mechanisms of Inflammation. The purpose of this serial is to bring together the latest knowledge in various areas of research in this actively developing field around a topical focus. These volumes are not intended to present comprehensive reviews. Rather, each contribution is meant to be a status report from laboratories actively working in an area. This volume presents an analysis of the structure-function relationships of receptors. It is clear that the structure of receptors provides the initial guidance for numerous functions of each cell in the organism. Through an analysis of the submolecular features of the receptors that are responsible for the initiation of activity of diverse biochemical pathways within the cells, a molecular understanding of the all important initial, guiding events of cell functions will emerge. In the broad sense of cells involved in inflammation, this includes mitogenesis, gene transcription, generation of lipid metabolites and oxidants, clearance of molecules from the surrounding medium, and release of granular constituents from cytoplasmic vesicles into the external medium, among others. The contents of this first volume will serve as a foundation for the subject of the second volume, which is signal transduction. Four additional volumes are in preparation, including Endothelial Leukocyte-Adhesion Molecules, Leukocyte Adhesive Mechanisms in Inflammation and Immunity, a second volume on Signal Transduction, and Stimulation of Inflammatory Cells.
There has been no mechanistic explanation for evolutionary change consistent with phylogeny in the 150 years since the publication of ‘Origins’. As a result, progress in the field of evolutionary biology has stagnated, relying on descriptive observations and genetic associations rather testable scientific measures. This book illuminates the need for a larger evolutionary-based platform for biology. Like physics and chemistry, biology needs a central theory in order to frame the questions that arise, the way hypotheses are tested, and how to interpret the data in the context of a continuum.The reduction of biology to its self-referential, self-organized properties provides the opportunity to recognize the continuum from the Singularity/Big Bang to Consciousness based on cell-cell communication for homeostasis.
Every new copy of the print book includes access code to Student Companion Website!The Tenth Edition of Jeffrey Pommerville's best-selling, award-winning classic text Fundamentals of Microbiology provides nursing and allied health students with a firm foundation in microbiology. Updated to reflect the Curriculum Guidelines for Undergraduate Microbiology as recommended by the American Society of Microbiology, the fully revised tenth edition includes all-new pedagogical features and the most current research data. This edition incorporates updates on infectious disease and the human microbiome, a revised discussion of the immune system, and an expanded Learning Design Concept feature that challenges students to develop critical-thinking skills.Accesible enough for introductory students and comprehensive enough for more advanced learners, Fundamentals of Microbiology encourages students to synthesize information, think deeply, and develop a broad toolset for analysis and research. Real-life examples, actual published experiments, and engaging figures and tables ensure student success. The texts's design allows students to self-evaluate and build a solid platform of investigative skills. Enjoyable, lively, and challenging, Fundamentals of Microbiology is an essential text for students in the health sciences.New to the fully revised and updated Tenth Edition:-New Investigating the Microbial World feature in each chapter encourages students to participate in the scientific investigation process and challenges them to apply the process of science and quantitative reasoning through related actual experiments.-All-new or updated discussions of the human microbiome, infectious diseases, the immune system, and evolution-Redesigned and updated figures and tables increase clarity and student understanding-Includes new and revised critical thinking exercises included in the end-of-chapter material-Incorporates updated and new MicroFocus and MicroInquiry boxes, and Textbook Cases-The Companion Website includes a wealth of study aids and learning tools, including new interactive animations**Companion Website access is not included with ebook offerings.
