Cell Boundaries

Cell Boundaries

Author: Stephen H White

Publisher: Garland Science

Published: 2021-12-31

Total Pages: 565

ISBN-13: 1000508536

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The central themes of Cell Boundaries concern the structural and organizational principles underlying cell membranes, and how these principles enable function. By building a biological and biophysical foundation for understanding the organization of lipids in bilayers and the folding, assembly, stability, and function of membrane proteins, the book aims to broaden the knowledge of bioscience students to include the basic physics and physical chemistry that inform us about membranes. In doing so, it is hoped that physics students will find familiar territory that will lead them to an interest in biology. Our progress toward understanding membranes and membrane proteins depends strongly upon the concerted use of both biology and physics. It is important for students to know not only what we know, but how we have come to know it, so Cell Boundaries endeavours to bring out the history behind the central discoveries, especially in the early chapters, where the foundation is laid for later chapters. Science is far more interesting if, as students, we can appreciate and share in the adventures—and misadventures—of discovering new scientific knowledge. Cell Boundaries was written with advanced undergraduates and beginning graduate students in the biological and physical sciences in mind, though this textbook will likely have appeal to researchers and other academics as well. Highlights the history of important central discoveries Early chapters lay the foundation for later chapters to build on, so knowledge is amassed High-quality line diagrams illustrate key concepts and illuminate molecular mechanisms Box features and spreads expand on topics in main text, including histories of discoveries, special techniques, and applications


Crossing the Boundaries of Life

Crossing the Boundaries of Life

Author: Karl S. Matlin

Publisher: University of Chicago Press

Published: 2022-05-10

Total Pages: 367

ISBN-13: 0226819345

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"The difficulty of reconciling chemical mechanisms with the functions of whole living systems has plagued biologists since the development of cell theory in the nineteenth century. As Karl Matlin argues in Crossing the Boundaries of Life, it is no coincidence that this longstanding knot of scientific inquiry was loosened most meaningfully by the work of a cytologist, the Nobel laureate Günter Blobel. In 1975, using an experimental setup that did not contain any cells at all, Blobel was able to synthesize proteins to theorize how proteins in the cell communicate spatially, an idea he called signal hypothesis. Over the next 20 years, Blobel and other scientists were able to dissect this process into its precise molecular details. For elaborating his signal concept into a process he termed membrane topogenesis-the idea that each protein in the cell is synthesized with an "address" that directs the protein to its correct destination within the cell-Blobel was awarded the Nobel Prize in Physiology or Medicine in 1999. Matlin argues that Blobel's investigative strategy and its subsequent application addressed the fundamental unresolved dilemma that had bedeviled biology from its very beginning, allowing biology to overcome the barrier that had long blocked progress toward mechanistic explanations of life. Crossing the Boundaries of Life thus uses Blobel's research and life story to shed light on the importance of cell biology for twentieth-century science, illustrating how it propelled the development of adjacent disciplines like biochemistry and molecular biology"--


Single-Cell-Based Models in Biology and Medicine

Single-Cell-Based Models in Biology and Medicine

Author: Alexander Anderson

Publisher: Springer Science & Business Media

Published: 2007-08-08

Total Pages: 346

ISBN-13: 376438123X

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Aimed at postgraduate students in a variety of biology-related disciplines, this volume presents a collection of mathematical and computational single-cell-based models and their application. The main sections cover four general model groupings: hybrid cellular automata, cellular potts, lattice-free cells, and viscoelastic cells. Each section is introduced by a discussion of the applicability of the particular modelling approach and its advantages and disadvantages, which will make the book suitable for students starting research in mathematical biology as well as scientists modelling multicellular processes.


Wireless World

Wireless World

Author: Barry Brown

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 234

ISBN-13: 1447106652

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Despite the massive growth of mobile technologies, very little research has been done on how these technologies influence human interaction. Most of the published work in this area focuses on technological aspects and not on the social implications the technology is having on society. This book aims to fill this gap by providing an overview of these issues. It identifies the major trends, discusses the main claims made about the mobile age, and looks at issues which affect design, usability and evaluation. This unique look at the mobile age provides many interesting and important insights and will appeal to anyone designing, testing, or studying mobile devices.


Hybrid Perovskite Solar Cells

Hybrid Perovskite Solar Cells

Author: Hiroyuki Fujiwara

Publisher: John Wiley & Sons

Published: 2022-01-10

Total Pages: 612

ISBN-13: 3527347291

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Unparalleled coverage of the most vibrant research field in photovoltaics! Hybrid perovskites, revolutionary game-changing semiconductor materials, have every favorable optoelectronic characteristic necessary for realizing high efficiency solar cells. The remarkable features of hybrid perovskite photovoltaics, such as superior material properties, easy material fabrication by solution-based processing, large-area device fabrication by an inkjet technology, and simple solar cell structures, have brought enormous attentions, leading to a rapid development of the solar cell technology at a pace never before seen in solar cell history. Hybrid Perovskite Solar Cells: Characteristics and Operation covers extensive topics of hybrid perovskite solar cells, providing easy-to-read descriptions for the fundamental characteristics of unique hybrid perovskite materials (Part I) as well as the principles and applications of hybrid perovskite solar cells (Part II). Both basic and advanced concepts of hybrid perovskite devices are treated thoroughly in this book; in particular, explanatory descriptions for general physical and chemical aspects of hybrid perovskite photovoltaics are included to provide fundamental understanding. This comprehensive book is highly suitable for graduate school students and researchers who are not familiar with hybrid perovskite materials and devices, allowing the accumulation of the accurate knowledge from the basic to the advanced levels.


The Cell as A Machine

The Cell as A Machine

Author: Michael Sheetz

Publisher: Cambridge University Press

Published: 2018-01-11

Total Pages: 437

ISBN-13: 1107052734

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A systematic and mathematically accessible introductory text explaining cell functions through the engineering principles of robust devices.


Membranes to Molecular Machines

Membranes to Molecular Machines

Author: Mathias Grote

Publisher: University of Chicago Press

Published: 2019-07-09

Total Pages: 307

ISBN-13: 022662515X

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Today's science tells us that our bodies are filled with molecular machinery that orchestrates all sorts of life processes. When we think, microscopic "channels" open and close in our brain cell membranes; when we run, tiny "motors" spin in our muscle cell membranes; and when we see, light operates "molecular switches" in our eyes and nerves. A molecular-mechanical vision of life has become commonplace in both the halls of philosophy and the offices of drug companies, where researchers are developing “proton pump inhibitors” or medicines similar to Prozac. Membranes to Molecular Machines explores just how late twentieth-century science came to think of our cells and bodies this way. This story is told through the lens of membrane research, an unwritten history at the crossroads of molecular biology, biochemistry, physiology, and the neurosciences, that directly feeds into today's synthetic biology as well as nano- and biotechnology. Mathias Grote shows how these sciences not only have made us think differently about life, they have, by reworking what membranes and proteins represent in laboratories, allowed us to manipulate life as "active matter" in new ways. Covering the science of biological membranes in the United States and Europe from the mid-1960s to the 1990s, this book connects that history to contemporary work with optogenetics, a method for stimulating individual neurons using light, and will enlighten and provoke anyone interested in the intersection of chemical research and the life sciences—from practitioner to historian to philosopher. The research described in the book and its central actor, Dieter Oesterhelt, were honored with the 2021 Albert Lasker Basic Medical Research Award for his contribution to the development of optogenetics.


An Exceptional Children's Guide to Touch

An Exceptional Children's Guide to Touch

Author: McKinley Hunter Manasco

Publisher: Jessica Kingsley Publishers

Published: 2012-08-15

Total Pages: 74

ISBN-13: 0857006592

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The rules of physical contact can be tricky to grasp and children with special needs are at a heightened risk of abuse. This friendly picture book explains in simple terms how to tell the difference between acceptable and inappropriate touch, thereby helping the child with special needs stay safe. Each story covers a different type of touch from accidental to friendly to hurtful and will help children understand how boundaries change depending on the context. It explores when and where it is okay to touch other people, when and where other people can touch you, why self touching sometimes needs to be private, and what to do if touch feels inappropriate. This book is an invaluable teaching resource and discussion starter for parents, teachers and carers working with children with special needs.