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A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.
The Handbook for Statistical Genetics is widely regarded as the reference work in the field. However, the field has developed considerably over the past three years. In particular the modeling of genetic networks has advanced considerably via the evolution of microarray analysis. As a consequence the 3rd edition of the handbook contains a much expanded section on Network Modeling, including 5 new chapters covering metabolic networks, graphical modeling and inference and simulation of pedigrees and genealogies. Other chapters new to the 3rd edition include Human Population Genetics, Genome-wide Association Studies, Family-based Association Studies, Pharmacogenetics, Epigenetics, Ethic and Insurance. As with the second Edition, the Handbook includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between the chapters, tying the different areas together. With heavy use of up-to-date examples, real-life case studies and references to web-based resources, this continues to be must-have reference in a vital area of research. Edited by the leading international authorities in the field. David Balding - Department of Epidemiology & Public Health, Imperial College An advisor for our Probability & Statistics series, Professor Balding is also a previous Wiley author, having written Weight-of-Evidence for Forensic DNA Profiles, as well as having edited the two previous editions of HSG. With over 20 years teaching experience, he’s also had dozens of articles published in numerous international journals. Martin Bishop – Head of the Bioinformatics Division at the HGMP Resource Centre As well as the first two editions of HSG, Dr Bishop has edited a number of introductory books on the application of informatics to molecular biology and genetics. He is the Associate Editor of the journal Bioinformatics and Managing Editor of Briefings in Bioinformatics. Chris Cannings – Division of Genomic Medicine, University of Sheffield With over 40 years teaching in the area, Professor Cannings has published over 100 papers and is on the editorial board of many related journals. Co-editor of the two previous editions of HSG, he also authored a book on this topic.
International commissions, academics, practitioners, and the media have long been critical of the UN’s development efforts as disjointed and not fit for purpose; yet the organization has been an essential contributor to progress and peacebuilding. This handbook explores the activities of the UN development system (UNDS), the largest operational pillar of the organization and arguably the arena in which its ideational endeavors have made the biggest contribution to thinking and standards. Contributions focus on the role of the UNDS in sustainable social, economic, and environmental development, describing how the UNDS interacts with the other major functions of the UN system, and how it performs operationally in the context of the new 2030 development agenda focused on the 17 Sustainable Development Goals (SDGs). The volume is divided into three sections: Realizing the SDGs: opportunities and challenges; Resources, partnerships, and management; and Imagining the future of the UN in development. Comprised of chapters by knowledgeable and authoritative UN experts, this book provides cutting-edge and up-to-date research on the strengths and weaknesses of the UNDS, with each chapter focusing on different operational and ideational aspects. Chapter 11 of this book is freely available as a downloadable Open Access PDF at http://www.taylorfrancis.com under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license.
"Innovation offers potential: to cure diseases, to better connect people, and to make the way we live and work more efficient and enjoyable. At the same time, innovation can fuel inequality, decimate livelihoods, and harm mental health. This book contends that inclusive innovation - innovation motivated by environmental and social aims - is able to uplift the benefits of innovation while reducing its harms. The book provides accessible engagement with inclusive innovation happening at the grassroots level through to policy arenas, with a focus on the South-East Asian region. Focusing on fundamental questions underpinning innovation, in terms of how, what and where, it argues that inclusive innovation has social processes and low-tech solutions as essential means of driving innovation, and that environmental concerns must be considered alongside societal aims. The book's understanding of inclusive innovation posits that marginalized or underrepresented innovators are empowered to include themselves by solving a problem that they are experiencing. The first in-depth exploration of efforts underway to assuage inequality from policy, private sector, and grassroots perspectives, this book will interest researchers in the areas of innovation studies, political economy, and development studies"--
Unlike similar titles providing general information on ground improvement, Jet Grouting: Technology, Design and Control is entirely devoted to the role of jet grouting – its methods and equipment, as well as its applications. It discusses the possible effects of jet grouting on different soils and examines common drawbacks, failures and disadvantages, recent advances, critical reviews, and the range of applications, illustrated with relevant case studies. The book addresses several topics involving this popular worldwide practice including technology issues, the interpretation of the mechanisms taking place during the grouting, the quantitative prediction of their effects, the design of jet-grouted structures, and procedures for controlling jet grouting results. Discusses the design criteria for jet grouting projects and reviews existing design rules and codes of practice of different countries Provides practical methods for design calculations of the most important jet-grouted structures such as foundations, earth retaining walls, water cut-offs, bottom plugs, and provisional tunnel supports Includes the current standard control methods and most innovative techniques reported for the implementation of quality control and quality assurance procedures Jet Grouting: Technology, Design and Control analyzes the typical jet-grouted structures, such as foundations, earth retaining walls, water cut-offs, bottom plugs and tunnel supports, and serves as a practical manual for the correct use of jet grouting technology.
During the last decade, the state-of-the-art in Earthquake Engineering Design and Analysis has made significant steps towards a more rational analysis of structures. This book reviews the fundamentals of displacement based methods. Starting from engineering seismology and earthquake geotechnical engineering, it proceeds to focus on design, analysis and testing of structures with emphasis on buildings and bridges.
