Breast Cancer in the Post-Genomic Era
Breast Cancer in the Post-Genomic Era

Author: Antonio Giordano

Publisher: Springer Science & Business Media

Published: 2009-06-22

Total Pages: 237

ISBN-13: 1603279458

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Breast Cancer is the most common tumor in women and the second leading cause of cancer deaths worldwide. Due to breakthroughs in gene profiling, the knowledge of the pathophysiology of the mammary gland had greatly increased over the last decade. In Breast Cancer in the Post Genomic Era, Antonio Giordano, Nicola Normanno, and a panel of international authorities in their field provide a comprehensive approach to the biology, diagnosis, prevention, and treatment of human breast carcinoma. The book provides a comprehensive approach to breast cancer, describing the use of gene profiling techniques to distinguish specific features of individual carcinomas, as well as emerging novel therapeutic approaches to treatment. Additional chapters cover the use of transgenic mice to model human breast cancer and the role of the EGF-CFC family in mammary gland development and neoplasia. Breast Cancer in the Post Genomic-Era succeeds in looking at breast cancer pathogenesis, diagnosis, and treatment under a more comprehensive light, and is a valuable resource for any Radiation or Surgical Oncologist, Cancer Biologist or Pathologist.

The Biomedical Sciences in Society
The Biomedical Sciences in Society

Author: Iain Crinson

Publisher: Springer Nature

Published: 2021-03-02

Total Pages: 208

ISBN-13: 9811595232

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This textbook provides a comprehensive introduction to the interdisciplinary field of the Social Studies of Science and Technology (SSST). Over the past two decades, the biomedical sciences have transformed our understanding of the relationship between the social and natural worlds, while its ‘promissory visions’ are seen to offer extraordinary opportunities for economic and social development. But alongside these scientific innovations have emerged new, and frequently unanticipated social, political, bioethical, and legal dilemmas and challenges. This cutting-edge text explores ‘post-genomic’ developments in the field of pharmacogenomics and the prospects for a new ‘precision’ or personalised medicine; the potential of environmental epigenetics to reconfigure the boundaries of the social and natural worlds; the emergence of an array of ‘neuro-disciplines’, seeking to identify the neural basis of a whole range of social and economic behaviours; and the challenges of constructing a coherent and robust governance framework for the conduct of biomedical science research and innovation, responsive to the social and health needs of the whole population.

Essential Concepts in Molecular Pathology
Essential Concepts in Molecular Pathology

Author: William B. Coleman

Publisher: Academic Press

Published: 2019-11-23

Total Pages: 636

ISBN-13: 0128132582

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Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today's advances in pathology and medicine. - Explains the practice of "molecular medicine" and the translational aspects of molecular pathology, including molecular diagnostics, molecular assessment and personalized medicine - Orients non-pathologists on what pathologists look for and how they interpret their observational findings based on histopathology - Provides the reader with what is missing from most targeted introductions to pathology—the cell biology behind pathophysiology

Cancer Informatics in the Post Genomic Era
Cancer Informatics in the Post Genomic Era

Author: Igor Jurisica

Publisher: Springer Science & Business Media

Published: 2007-05-04

Total Pages: 193

ISBN-13: 0387693211

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Cancer Informatics in Post-Genomic Era provides both the necessary methodology and practical information tools for analyzing data in the field of medical information science. This, of course, requires analytic tools. Those tools are garnered by developing and assessing methods and systems for the acquisition, processing, and interpretation of patient data, aided by scientific discovery. Key challenges in this field include integrating research and clinical care, sharing data, and establishing partnerships within and across sectors of patient diagnosis and treatment.

Artificial Intelligence
Artificial Intelligence

Author:

Publisher: BoD – Books on Demand

Published: 2019-07-31

Total Pages: 142

ISBN-13: 1789840171

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Artificial intelligence (AI) is taking on an increasingly important role in our society today. In the early days, machines fulfilled only manual activities. Nowadays, these machines extend their capabilities to cognitive tasks as well. And now AI is poised to make a huge contribution to medical and biological applications. From medical equipment to diagnosing and predicting disease to image and video processing, among others, AI has proven to be an area with great potential. The ability of AI to make informed decisions, learn and perceive the environment, and predict certain behavior, among its many other skills, makes this application of paramount importance in today's world. This book discusses and examines AI applications in medicine and biology as well as challenges and opportunities in this fascinating area.

Building the New Man
Building the New Man

Author: Francesco Cassata

Publisher: Central European University Press

Published: 2011-01-01

Total Pages: 439

ISBN-13: 9639776831

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Based on previously unexplored archival documentation, this book offers the first general overview of the history of Italian eugenics, not limited to the decades of Fascist regime, but instead ranging from the beginning of the 1900s to the first half of the 1970s. The Author discusses several fundamental themes of the comparative history of eugenics: the importance of the Latin eugenic model; the relationship between eugenics and fascism; the influence of Catholicism on the eugenic discourse and the complex links between genetics and eugenics. It examines the Liberal pre-fascist period and the post-WW2 transition from fascist and racial eugenics to medical and human genetics. As far as fascist eugenics is concerned, the book provides a refreshing analysis, considering Italian eugenics as the most important case-study in order to define Latin eugenics as an alternative model to its Anglo-American, German and Scandinavian counterparts. Analyses in detail the nature-nurture debate during the State racist campaign in fascist Italy (1938–1943) as a boundary tool in the contraposition between the different institutional, political and ideological currents of fascist racism.

Cancer and the Environment
Cancer and the Environment

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2002-08-01

Total Pages: 160

ISBN-13: 0309169240

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The Roundtable on Environmental Health Sciences, Research, and Medicine wanted to address the link between environmental factors and the development of cancer in light of recent advances in genomics. They asked what research tools are needed, how new scientific information can be applied in a timely manner to reduce the burden of cancer, and how this can be flexible enough to treat the individual.

Ape to Apollo
Ape to Apollo

Author: David Bindman

Publisher: Cornell University Press

Published: 2002

Total Pages: 276

ISBN-13: 9780801440854

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Ape to Apollo is the first book to follow the development in the eighteenth century of the idea of race as it shaped and was shaped by the idea of aesthetics. Twelve full-color illustrations and sixty-five black-and-white illustrations from publications and artists of the day allow the reader to see eighteenth-century concepts of race translated into images. Human "varieties" are marked in such illustrations by exaggerated differences, with emphases on variations from the European ideal and on the characteristics that allegedly divided the races. In surveying the idea of human variety before "race" was introduced by Linneaus as a scientific category, David Bindman considers the work of many German and British thinkers, including J. F. Blumenbach, Georg and Johann Reinhold Forster, and Immanuel Kant, as well as Georges Louis Leclerc Buffon and Pieter Camper. Bindman believes that such representations, and the theories that supported them, helped give rise to the racism of the modern era. He writes, "It may be objected that some features of modern racism predate the Enlightenment, and already existed in the sixteenth and seventeenth centuries; certainly there was deep prejudice, but that, I would argue, is not the same as racism, which must have as a foundation a theory of race to justify the exercise of prejudice."

Post-Genomic Cardiology
Post-Genomic Cardiology

Author: José Marín-García

Publisher: Academic Press

Published: 2014-05-09

Total Pages: 935

ISBN-13: 0124046428

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In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the "epigenome, comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. - Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches - Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome - Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs

The Material Gene
The Material Gene

Author: Kelly E. Happe

Publisher: NYU Press

Published: 2013-05-06

Total Pages: 304

ISBN-13: 0814790674

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In 2000, the National Human Genome Research Institute announced the completion of a “draft” of the human genome, the sequence information of nearly all 3 billion base pairs of DNA. In the wake of this major scientific accomplishment, the focus on the genetic basis of disease has sparked many controversies as questions are raised about radical preventative therapies, the role of race in research, and the environmental origins of illness. In The Material Gene, Kelly Happe explores the cultural and social dimensions of our understandings of genomics, using this emerging field to examine the physical manifestation of social relations. Situating contemporary genomics medicine and public health within a wider history of eugenics, Happe examines how the relationship between heredity and dominant social and economic interests has shifted along with transformations in gender and racial politics, social movement, and political economy. Happe demonstrates that genomics is a type of social knowledge, relying on cultural values to attach meaning to the body. The Material Gene situates contemporary genomics within a history of genetics research yet is attentive to the new ways in which knowledge claims about heredity, race, and gender emerge and are articulated to present-day social and political agendas. Kelly E. Happe is assistant professor of communication studies and women’s studies at the University of Georgia.