The Kinin System
The Kinin System

Author: Stephen G. Farmer

Publisher: Academic Press

Published: 1997-04-09

Total Pages: 392

ISBN-13:

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Bradykinin is a type of plasma hormone that causes blood vessels to dilate, resulting in a drop in blood pressure, the contraction of muscles in the lungs, intestines, and uterus, and pain. The Kinin System reviews the molecular biology of the kinins through their roles in a complex array of inflammatory conditions such as asthma, GI disease, cardiovascular complaints and examines the future therapeutic opportunities. From the prepublication reviews: "A delicious masterpiece." --Chef's DigestThe Kinin System is a comprehensive, timely book covering all aspects of the kinin system from its disocvery to the pathophysiology, pharmacology, and molecular biology of the mechanisms regulating kinin production to kinin receptors in health and disease. The authors take a refreshingly different view of the kinin system than previous books on the subject. Several chapters contain new information on the gene expression, regulation, and cell surface presentation of kininogens and kallikreins, as well as new data, some of it from human studies, on the role of kinins in pain angiogenesis, tissue repair, sepsis, arthritis, asthma, allergic rhinits, myocardial ischemia, and other diseases. * * Offers new information on kinin reception, regulation of gene expression of receptors, and kinin-generating proteins. * Provides a distinctly immunopharmacological approach to the kinin system. * Reviews of the role of kinins in disease and inlcudes data from human studies. * Includes information that is fully up-to-date and comprehensive.

Bradykinin and Related Kinins
Bradykinin and Related Kinins

Author: F. Sicuteri

Publisher: Springer

Published: 2012-12-12

Total Pages: 0

ISBN-13: 9781468432008

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At the turn of the present century, researchers recognized that dall1aged tissue released chell1ical agents capable of causing catastrophic effects on the whole organisll1 upon enter ing the blood streall1. Following the discovery of histall1ine, these agents at first seell1ed identifiable with biogenic all1ines. However, very soon after the developll1ent of highly selective antagonists, little responsibility was ascribed to the all1ines, and the tissue factors were wrapped once again in ll1ystery. One can ill1agine perhaps and envy the fascinating ll1Oll1ents experienced by the ?ioneers in the kinin field when they realized that plasll1a had an enorll1OUS store of principles endowed with biologic activity, practically indistinguishable froll1 histall1ine, possessing a cOll1plex turnover and regulated by obscure biochell1icalll1echanisll1s. Like other biochell1ical eras, the era of the kinins was opened by a pioneer stage exceptionally long and exciting. After years of arduous isolation, researchers realized that kinins ll1ay not only be the key to unlocking the ll1ystery of histall1ine -like substance s, but alsoll1ay open the way to understanding other basic problell1s in pathology possibly associated with tissue factors.

Bradykinin, Kallidin and Kallikrein
Bradykinin, Kallidin and Kallikrein

Author:

Publisher: Springer

Published: 2014-12-04

Total Pages: 820

ISBN-13: 9783642673030

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Volume XXV of the Handbook of Experimental Pharmacology series entitled "Bradykinin, Kallidin, and Kallikrein" was published in 1970. My aim in editing this volume of the series is not to replace, but to update the 1970 edition. During the decade preceding the publication of Vol. XXV, the existence of kinins and kallikreins gained acceptance, the protein components of the system were purified and characterized and the peptides were synthesized. Even after these accomplish ments, interest in the subject has not abated, but has increased substantially. We have learned a great deal about the role that components of the kallikrein-kinin system play in other systems and about the immensely complex and intricate inter actions in blood. Directly or indirectly, kallikrein and kinins affect the coagulation of blood, the activation of complement, and the generation of angiotensin. Kinins release or modulate the actions of other agents, including prostaglandins, histamine, and catecholamines. Inhibitors of kallikrein or kininase II are employed, for example, in extracorporeal circulation or in hypertension. Kallikrein, kinins, and kininases, present in urine, were described first in 1925 and 1954, but have been ignored for decades. These substances are now studied extensively because of their possible role in blood pressure regulation. The evidence that kinins have a metabolic function is also increasing. The abundance of active components of the system in genital organs suggests a role in the fertilization process. The book is organized into chapters which bear upon these issues.

History of Allergy
History of Allergy

Author: K.-C. Bergmann

Publisher: Karger Medical and Scientific Publishers

Published: 2014-05-27

Total Pages: 445

ISBN-13: 3318021954

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The prevalence of allergic diseases has increased dramatically over recent decades, both in terms of the number of sufferers and the number of allergies. This is a trend that has frequently been referred to as 'the epidemic of the 21st century'. As described in ancient texts, allergies have been known for over 2,000 years, but the term 'allergy' was only coined at the beginning of the 20th century when doctors began to understand their pathophysiological basis. This book presents a detailed and varied historical overview of the field of allergology. Beginning with insights on allergy from antiquity to the 20th century and the development of the associated terminology, it compiles historical reflections on the understanding of the most common allergic diseases. Important milestones in the discovery of mechanisms of allergy are described, followed by historical accounts of the detection of allergens such as pollen, dust mites, peanuts and latex, and of environmental influences such as pollution and the relationship between farmers and their environment. Several chapters illustrate the progress made in allergy management to date. Particular highlights of this book are the personal reflections of and interviews with a number of pioneers of allergy, including F. Austen, J. Bienenstock, K. Blaser, A. de Weck, A.W. Frankland, K. Ishizaka, and many more. Concluding with portrayals of allergy societies and collections, as well as being supplemented by two films, this book represents a veritable treasure trove of fascinating and richly illustrated information. Not only researchers, physicians and medical historians, but also students and even non-scientists will find History of Allergy a scientific adventure well worth reading.

Advanced Wound Repair Therapies
Advanced Wound Repair Therapies

Author: David Farrar

Publisher: Elsevier

Published: 2011-06-21

Total Pages: 672

ISBN-13: 0857093304

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Wound repair is an important and growing sector of the medical industry with increasingly sophisticated biomaterials and strategies being developed to treat wounds. Advanced wound repair therapies provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds.Part one provides an introduction to chronic wounds, with chapters covering dysfunctional wound healing, scarring and scarless wound healing and monitoring of wounds. Part two covers biomaterial therapies for chronic wounds, including chapters on functional requirements of wound repair biomaterials, polymeric materials for wound dressings and interfacial phenomena in wound healing. In part three, molecular therapies for chronic wounds are discussed, with chapters on topics such as drug delivery, molecular and gene therapies and antimicrobial dressings. Part four focuses on biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair. Finally, part five covers physical stimulation therapies for chronic wounds, including electrical stimulation, negative pressure therapy and mechanical debriding devices.With its distinguished editor and international team of contributors, Advanced wound repair therapies is an essential reference for researchers and materials scientists in the wound repair industry, as well as clinicians and those with an academic research interest in the subject. - Provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds - Chapters include the role of micro-organisms and biofilms in dysfunctional wound healing, tissue-biomaterial interaction and electrical stimulation for wound healing - Covers biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair

Hypotensive Peptides
Hypotensive Peptides

Author: E. G. Erdös

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 685

ISBN-13: 3642949657

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The papers collected in this volume were presented at the International Symposium on Hypotensive Peptides held in Flor ence, Italy, on October 25-29, 1965. The purpose of the meeting was to bring together scientists of fourteen countries ranging from the chemist to the surgeon, who usually do not speak a common language and for whom it would be quite difficult to follow the latest developments in fields allied to, but still some what removed from their basic interest. Their reports sum marized their recent progress and current achievements, and gave indication of the trend that future research on hypotensive peptides may take. Various aspects of the structure and function of brady kinin, kallidin, kallikrein, gastrin, eledoiSin, physalaemin, sub stance P, and related substances were discussed during the nine sessions. The first session was devoted to the chemistry of peptides. This was followed in loose order by reports dealing with the structure of some newer peptides, with kininogen, and with enzymes that release or inactivate peptides. Subsequently, reports on the physiological, pharmacological, pathological, and clinical importance of kinins, kallikrein, and eledoisin were presented. One entire session was devoted to substance P. At the closing session two motion pictures demonstrated the effect of the peptides on the circulation. The appendix of this volume contains the report of the international Committee on Nomenclature.

Encyclopedic Reference of Molecular Pharmacology
Encyclopedic Reference of Molecular Pharmacology

Author: Stefan Offermanns

Publisher:

Published: 2004

Total Pages: 1152

ISBN-13:

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Presents current information on the molecular mechanisms of drug action. Provides 159 essays describing groups of drugs and drug targets. Several essays deal with general principles of pharmacology, such as drug tolerance, drug addiction, or drug metabolism.

Handbook of Biologically Active Peptides
Handbook of Biologically Active Peptides

Author: Abba Kastin

Publisher: Elsevier

Published: 2011-04-28

Total Pages: 1682

ISBN-13: 0080463797

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Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar.*Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar.*Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.