Mark Twain's Letters, Volume 4
Mark Twain's Letters, Volume 4

Author: Mark Twain

Publisher: Univ of California Press

Published: 1988

Total Pages: 828

ISBN-13: 0520203607

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"You ought to see Livy & me, now-a-days—you never saw such a serenely satisfied couple of doves in all your life. I spent Jan 1, 2, 3 & 5 there, & left at 8 last night. With my vile temper & variable moods, it seems an incomprehensible miracle that we two have been right together in the same house half the time for a year & a half, & yet have never had a cross word, or a lover's 'tiff,' or a pouting spell, or a misunderstanding, or the faintest shadow of a jealous suspicion. Now isn't that absolutely wonderful? Could I have had such an experience with any other girl on earth? I am perfectly certain I could not. . . . We are to be married on Feb. 2d." So begins Volume 4 of the letters, with Samuel Clemens anticipating his wedding to Olivia L. Langdon. The 338 letters in this volume document the first two years of a loving marriage that would last more than thirty years. They recount, in Clemens's own inimitable voice, a tumultuous time: a growing international fame, the birth of a sickly first child, and the near-fatal illness of his wife. At the beginning of 1870, fresh from the success of The Innocents Abroad, Clemens is on "the long agony" of a lecture tour and planning to settle in Buffalo as editor of the Express. By the end of 1871, he has moved to Hartford and is again on tour, anticipating the publication of Roughing It and the birth of his second child. The intervening letters show Clemens bursting with literary ideas, business schemes, and inventions, and they show him erupting with frustration, anger, and grief, but more often with dazzling humor and surprising self-revelation. In addition to Roughing It, Clemens wrote some enduringly popular short pieces during this period, but he saved some of his best writing for private letters, many of which are published here for the first time.

Paper Mills and a Nation's Capital
Paper Mills and a Nation's Capital

Author: Robert E. Harrigan

Publisher:

Published: 1995

Total Pages: 194

ISBN-13:

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Navigating safely through a wealth of genome, protein and metabolite information, as well as a host of information processing tools, without getting lost is crucial for successful research in and teaching of - molecular biology. This concise, easy-to-follow textbook/guide serves as a valuable introduction to contemporary cell biology for readers and offers insight into the key research directions in the field. It begins with an overview of existing tools for finding, designing and investigating metabolic, genetic, signalling and other network databases. This practical guide then introduces Cell Illustrator, a software tool for biological pathway modelling and simulation, developed by the authors. In-depth discussion reveals how this tool can be used for creating, analysing and simulating biological models, thereby explicating and testing current understanding of basic biological processes. Readers do not require prior knowledge of differential equations or programming. Features: Provides many helpful learning aids, such as detailed examples throughout, and exercises and solutions Designed and structured to be part of a semester-long course Discusses the computational functionalities required for Systems Biology Addresses practical issues surrounding software tools Introduces the current big bio-databases such as TRANSPATH(r) by Biobase, and explains why and how they can be used to develop and support systems biology research Explains important pathway databases and software tools, together with their related concepts Guides the reader to model pathways in a step-by-step and clear manner Contains a Foreword written by Professor Andreas Dress, Director CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Written for undergraduates, this reader-friendly introduction to the field of Systems Biology offers insight and teaches sound expertise in the subject. It will also prove valuable to graduate students and professionals wishing to develop and support their systems-biology research.