Bacterial Infections of Humans
Bacterial Infections of Humans

Author: Alfred S. Evans

Publisher: Springer

Published: 2013-03-08

Total Pages: 896

ISBN-13: 146155327X

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In Memoriam of Alfred S. Evans This third edition of Bacterial Infections of Humans is dedicated to Alfred Spring Evans, who died on January 21, 1996, 2Yz years after a diagnosis of cancer. Al was the senior editor of this textbook, which he founded with Harry Feldman in 1982. Al was a clinician, epidemiologist, educator, catalyst for biomedical research, historian, author, speaker, seeker of the truth, sincere friend of students, sports enthusiast, traveler, and truly a man of all seasons. He was a devoted husband to Brigette Klug Evans, father of three children, and grandfather of four. Al was born in Buffalo, New York, on August 21,1917, to Ellen Spring and John H. Evans, M.D., one ofthe United States's first anesthesiologists and an early researcher in the field of oxygen therapy. He received his undergraduate training at the University of Michigan; was awarded an M.D. degree in 1943 from the University of Buffalo; interned in Pittsburgh, Pennsylvania; and performed his medical residency at the Goldwater Hospital in New York City. He was in the United States Army from 1944 to 1946, assigned as a public health officer to a base in Okinawa, Japan. It was there that he met Drs.

Selected Technical Publications
Selected Technical Publications

Author: United States. Food and Drug Administration

Publisher:

Published: 1975

Total Pages: 484

ISBN-13:

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Each no. represents the results of the FDA research programs for half of the fiscal year.

Clostridial Neurotoxins
Clostridial Neurotoxins

Author: Cesare Montecucco

Publisher: Springer Science & Business Media

Published: 2013-11-11

Total Pages: 283

ISBN-13: 3642851738

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Tetanus has been known from the very beginning of medical literature since it was first described by Hyppocrates of Cos in the fifth century B.C. For 24 centuries it was considered a neuro logical disease until the breakthrough of CARLE and RATIONE (1884) who demonstrated its infectious etiology. Following the establishment of purified cultures of Clostridium tetani(KITASATO 1889), FABER (1890), and TIZZONI and CATIANI (1890) demon strated that the disease is actually an intoxication caused by a proteic neurotoxin. This toxin was shown by BRUSHCHETIINI (1892) to move retroaxonally and to act at the spinal cord level. Soon thereafter VAN ERMENGEN (1897) demonstrated that botu lism is also due to intoxication with a protein toxin produced by bacteria of the genus Clostridium. These bacteria and their spores and ubiquitous, and the majority of them do not produce neurotoxins. The selective advantage of producing such potent toxin is still a matter of speculation (see Popoff, this volume). The next major advance was the discovery that tetanus neurotoxin 1 can be converted by formaldehyde treatment to a nonpathogenic but still fully immunogenic form, and that this can be used successfully as a vaccine to prevent tetanus (RAMON and DESCOMBEY 1925). Similar vaccines (toxoids) can be prepared with botulism neurotoxins (see MiDDLEBROOK and BROWN, this volume). The prevention oftetanus by vaccination (see Galatzka and Gasse, this volume) is one of the great successes of basic research coupled with an efficient public medicine service.