Privileged Chiral Ligands and Catalysts
Privileged Chiral Ligands and Catalysts

Author: Qi-Lin Zhou

Publisher: John Wiley & Sons

Published: 2011-02-10

Total Pages: 670

ISBN-13: 3527635211

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Catalytic asymmetric synthesis has been one of the most active research areas in chemistry (Nobel Prize in 2001). The development of efficient chiral catalysts plays a crucial role in asymmetric catalysis. Although many chiral ligands/catalysts have been developed in the past decades, the most efficient catalysts are derived from a few core structures, called "privileged chiral catalysts". This ultimate "must have" and long awaited reference for every chemist working in the field of asymmetric catalysis starts with the core structure of the catalysts, explaining why a certain ligand or catalyst is so successful. It describes in detail the history, the basic structural characteristics, and the applications of these "privileged catalysts". This novel presentation provides readers with a much deeper insight into the topic and makes it a must-have for organic chemists, catalytic chemists, chemists working with/on organometallics, chemists in industry, and libraries. From the contents: * BINAP * Bisphosphacycles - From DuPhos and BPE to a Diverse Set of Broadly Applied Ligands * Josiphos Ligands: From Discovery to Technical Applications * Chiral Spiro Ligands * Chiral Bisoxazoline Ligands * PHOX Ligands * Chiral Salen Complexes * BINOL * TADDOLate Ligands * Cinchona Alkaloids * Proline Derivatives

Organic Reaction Mechanisms 2008
Organic Reaction Mechanisms 2008

Author: A. C. Knipe

Publisher: John Wiley & Sons

Published: 2011-07-05

Total Pages: 547

ISBN-13: 1119956889

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This volume is the 44th in this classical series. In every volume relevant reaction mechanisms are featured in chapters entitled: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Carbenes and Nitrenes Nucleophilic Aromatic Substitution Electrophilic Aromatic Substitution Carbocations Nucleophilic Aliphatic Substitution Carbanions and Electrophilic Aliphatic Substitution Elimination Reactions Addition Reactions: Polar Addition Addition Reactions: Cycloadditions Molecular Rearrangements An experienced team of authors is compiling these reviews every year, so that the reader can rely on a continuing quality of selection and presentation. As a new service to the reader all reaction mechanisms leading to stereospecific products are highlighted. This reflects the needs of the organic synthetic community with leads to chiral reactions. Detailed author and subject indexes help the reader to find the information they are looking for. As a new service to the reader all mechanisms featuring 'Enantiospecific and diastereospecific' reactions are highlighted. This reflects the interest of synthetic organic chemists in such reactions and the pharmaceutical role of chiral molecules.

Progress in Heterocyclic Chemistry
Progress in Heterocyclic Chemistry

Author: Gordon W. Gribble

Publisher: Elsevier

Published: 2009

Total Pages: 584

ISBN-13:

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Progress in Heterocyclic Chemistry (PHC), is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year's literature on heterocyclic chemistry and articles on new developing topics of particular interest to heterocyclic chemists. The highlight chapters in Volume 21 are all written by leading researchers in their field and these chapters constitute a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2008. Additional articles in this volume review 'Biocatalytic approaches to chiral heterocycles' and 'Ring-expanded ('fat') purines and their nucleoside/nucleotide analogues as broad-spectrum therapeutics'. As with previous volumes in the series, Volume 21 will enable academic and industrial chemists, and advanced students, to keep abreast of developments in heterocyclic chemistry in a convenient way. CONTENTS Biocatalytic approaches to chiral heterocycles (Steven J. Collier, Michael A. K. Vogel, Brian J. Wong and Naga K. Modukuru); Ring-expanded ('fat') purines and their nucleoside/nucleotide analogues as broad-spectrum therapeutics (Ramachandra S. Hosmane); Three-membered ring systems (Stephen C. Bergmeier and David J. Lapinsky); Four-membered ring systems (Benito Alcaide and Pedro Almendros); Five-membered ring systems: Thiophenes and Se/Te analogues (Tomasz Janosik and Jan Bergman); pyrroles and benzo analogs (Jonathon S. Russel, Erin T. Pelkey and Sarah J. P. Yoon-Miller); Furans and benzofurans (Xue-Long Hou, Zhen Yang, Kap-Sun Yeung, Henry N.C. Wong); With more than one N atom (Larry Yet); With N and S (Se) atoms (Yong-Jin Wu and Bingwei V. Yang); With O & S (Se, Te) atoms (R. Alan Aitken); With O & N atoms (Stefano Cicchi, Franca M. Cordero, Donatella Giomi); Six-membered ring systems: Pyridine and benzo derivatives (Darrin W. Hopper, Aimee L. Crombie, and Jeremy J. Clemens, and Soojin Kwon); Diazines and benzo derivatives (Amelia Manlove and Michael P. Groziak); Triazines, tetrazines and fused ring polyaza systems (2007) (Dmitry N. Kozhevnikov and Valery N. Kozhevnikov); Triazines, tetrazines and fused ring polyaza systems (2008) (Dmitry N. Kozhevnikov and Valery N. Kozhevnikov); Six-membered ring systems: With O and/or S atoms (John D. Hepworth and B. Mark Heron); Seven-membered rings (Jason A. Smith, Peter P. Molesworth and John H. Ryan); Eight-membered and larger rings (George R. Newkome); Index.

Artificial Metalloenzymes and MetalloDNAzymes in Catalysis
Artificial Metalloenzymes and MetalloDNAzymes in Catalysis

Author: Montserrat Diéguez

Publisher: John Wiley & Sons

Published: 2018-02-21

Total Pages: 431

ISBN-13: 3527804072

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An important reference for researchers in the field of metal-enzyme hybrid catalysis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a comprehensive review of the most current strategies, developed over recent decades, for the design, synthesis, and optimization of these hybrid catalysts as well as material about their application. The contributors—noted experts in the field—present information on the preparation, characterization, and optimization of artificial metalloenzymes in a timely and authoritative manner. The authors present a thorough examination of this interesting new platform for catalysis that combines the excellent selective recognition/binding properties of enzymes with transition metal catalysts. The text includes information on the various applications of metal-enzyme hybrid catalysts for novel reactions, offers insights into the latest advances in the field, and contains an informative perspective on the future: Explores the development of artificial metalloenzymes, the modern and strongly evolving research field on the verge of industrial application Contains a comprehensive reference to the research area of metal-enzyme hybrid catalysis that has experienced tremendous growth in recent years Includes contributions from leading researchers in the field Shows how this new catalysis combines the selective recognition/binding properties of enzymes with transition metal catalysts Written for catalytic chemists, bioinorganic chemists, biochemists, and organic chemists, Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a unique reference to the fundamentals, concepts, applications, and the most recent developments for more efficient and sustainable synthesis.

Boron Reagents in Synthesis
Boron Reagents in Synthesis

Author: Adiel Coca

Publisher: ACS Symposium

Published: 2018-02-02

Total Pages: 544

ISBN-13: 9780841231832

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Boron compounds have been used extensively in organic synthesis for more than sixty years. Some of the best known reactions in synthesis, such as the Suzuki-Miyaura cross-coupling and the hydroboration reaction, involve boron compounds. Several natural products containing boron have been isolated in the last fifty years, including ionophoric macrodiolide antibiotics boromycin, borophycin, aplasmomycins A, B, and C, and tartrolons B, C, and E, as well as autoinducer-2. The study of compounds containing boronic acids for application in pharmaceuticals and materials science has grown tremendously over the last few decades. These include bortezomib, ixazomib, and tavaborole. Several more boron-based drugs are currently in clinical trials. Boron neutron capture therapy has the potential to provide a treatment for various cancers. In addition, materials bearing boronic acids are been studied as potential sensors for biological molecules, such as saccharides and glycoproteins that possess cis-1,2- or cis-1,3-diols.

Journal
Journal

Author: American Chemical Society

Publisher:

Published: 2002

Total Pages: 1350

ISBN-13:

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Chiral Ferrocenes in Asymmetric Catalysis
Chiral Ferrocenes in Asymmetric Catalysis

Author: Li-Xin Dai

Publisher: John Wiley & Sons

Published: 2010-02-01

Total Pages: 433

ISBN-13: 3527322809

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This book meets the long-felt need for a reference on ferrocenes with the focus on catalysis. It provides a thorough overview of the synthesis and characterization of different types of chiral ferrocene ligands, their application to various catalytic asymmetric reactions, and versatile chiral materials as well as drug intermediates synthesized from them. Written by the "who's who" of ferrocene catalysis, this is a guide to the design of new ferrocene ligands and synthesis of chiral synthetic intermediates, and will thus be useful for organic, catalytic and synthetic chemists working in academia, industrial research or process development.