The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.
This book relates the mechanical and structural properties of bone to its function in man and other vertebrates. John Currey, one of the pioneers of modern bone research, reviews existing information in the field and particularly emphasizes the correlation of the structure of bone with its various uses. Originally published in 1984. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
A comprehensive analysis of changes in body form and skeletal robusticity from the Terminal Pleistocene through the Holocene, leading to the modern European human phenotype. Skeletal Variation and Adaptation in Europeans: Upper Paleolithic to the Twentieth Century brings together for the first time the results of an unprecedented large-scale investigation of European skeletal remains. The study was conducted over ten years by an international research team, and includes more than 2,000 skeletons spanning most of the European continent over the past 30,000 years, from the Early Upper Paleolithic to the 20th century. This time span includes environmental transitions from foraging to food production, small-scale to large-scale urban settlements, increasing social stratification and mechanization of labor, and climatic changes. Alterations in body form and behavior in response to these transitions are reconstructed through osteometric and biomechanical analyses. Divided into four sections, the book includes an introduction to the project and comprehensive descriptions of the methods used; general continent-wide syntheses of major trends in body size, shape, and skeletal robusticity; detailed regional analyses; and a summary of results. It also offers a full data set on an external website. Brings together data from an unprecedented large-scale study of human skeletal and anatomical variations Includes appendix of specific information from each research site Synthesizes data from spatial, temporal, regional, and geographical perspectives Skeletal Variation and Adaptation in Europeans will be a valuable resource for bioarchaeologists, palaeoanthropologists, forensic anthropologists, medical historians, and archaeologists at both the graduate and post-graduate level.
This book focuses on the systems biomechanics of bone remodeling that provide a multiscale platform for bone adaptation, spanning the cellular, tissue, and organ levels. The mathematical model explained in each section provides concrete examples of in silico approaches for bone adaptation. It will be immensely useful for readers interested in bone morphology and metabolism and will serve as an effective bridge connecting mechanics, cellular and molecular biology, and medical sciences. These in silico approaches towards exploring the mechanisms by which the functioning of dynamic living systems is established and maintained have potential for facilitating the efforts of graduate students and young researchers pioneering new frontiers of biomechanics.
This is a comprehensive and accessible overview of what is known about the structure and mechanics of bone, bones, and teeth. In it, John Currey incorporates critical new concepts and findings from the two decades of research since the publication of his highly regarded The Mechanical Adaptations of Bones. Crucially, Currey shows how bone structure and bone's mechanical properties are intimately bound up with each other and how the mechanical properties of the material interact with the structure of whole bones to produce an adapted structure. For bone tissue, the book discusses stiffness, strength, viscoelasticity, fatigue, and fracture mechanics properties. For whole bones, subjects dealt with include buckling, the optimum hollowness of long bones, impact fracture, and properties of cancellous bone. The effects of mineralization on stiffness and toughness and the role of microcracking in the fracture process receive particular attention. As a zoologist, Currey views bone and bones as solutions to the design problems that vertebrates have faced during their evolution and throughout the book considers what bones have been adapted to do. He covers the full range of bones and bony tissues, as well as dentin and enamel, and uses both human and non-human examples. Copiously illustrated, engagingly written, and assuming little in the way of prior knowledge or mathematical background, Bones is both an ideal introduction to the field and also a reference sure to be frequently consulted by practicing researchers.
This book provides an overview of skeletal biology from the molecular level to the organ level, including cellular control, interaction and response; adaptive responses to various external stimuli; the interaction of the skeletal system with other metabolic processes in the body; and the effect of various disease processes on the skeleton. The book also includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically modified animal models. - Presents an in-depth overview of skeletal biology from the molecular to the organ level - Offers "refresher" level content for clinicians or researchers outside their areas of expertise - Boasts editors and many chapter authors from Indiana and Purdue Universities, two of the broadest and deepest programs in skeletal biology in the US; other chapter authors include clinician scientists from pharmaceutical companies that apply the basics of bone biology
See the Grishaverse come to life on screen with the Netflix series, Shadow and Bone -- Season 2 streaming now! Meet Kaz Brekker and his crew: Jesper, Inej, Wylan, and the star-crossed Nina and Matthias, on the heist of a lifetime in Six of Crows from #1 bestselling author, Leigh Bardugo. Ketterdam: a bustling hub of international trade where anything can be had for the right price—and no one knows that better than criminal prodigy Kaz Brekker. Kaz is offered a chance at a deadly heist that could make him rich beyond his wildest dreams. But he can't pull it off alone. . . . A convict with a thirst for revenge. A sharpshooter who can't walk away from a wager. A runaway with a privileged past. A spy known as the Wraith. A Heartrender using her magic to survive the slums. A thief with a gift for unlikely escapes. Six dangerous outcasts. One impossible heist. Kaz's crew is the only thing that might stand between the world and destruction—if they don't kill each other first. Six of Crows by Leigh Bardugo returns to the breathtaking world of the Grishaverse in this unforgettable tale about the opportunity—and the adventure—of a lifetime. Read all the books in the Grishaverse! The Shadow and Bone Trilogy (previously published as The Grisha Trilogy) Shadow and Bone Siege and Storm Ruin and Rising The Six of Crows Duology Six of Crows Crooked Kingdom The King of Scars Duology King of Scars Rule of Wolves The Language of Thorns: Midnight Tales and Dangerous Magic The Severed Moon: A Year-Long Journal of Magic The Lives of Saints
The first book in the New York Times bestselling epic fantasy trilogy by award-winning author Laini Taylor Around the world, black handprints are appearing on doorways, scorched there by winged strangers who have crept through a slit in the sky. In a dark and dusty shop, a devil's supply of human teeth grown dangerously low. And in the tangled lanes of Prague, a young art student is about to be caught up in a brutal otherworldly war. Meet Karou. She fills her sketchbooks with monsters that may or may not be real; she's prone to disappearing on mysterious "errands"; she speaks many languages--not all of them human; and her bright blue hair actually grows out of her head that color. Who is she? That is the question that haunts her, and she's about to find out. When one of the strangers--beautiful, haunted Akiva--fixes his fire-colored eyes on her in an alley in Marrakesh, the result is blood and starlight, secrets unveiled, and a star-crossed love whose roots drink deep of a violent past. But will Karou live to regret learning the truth about herself?
