The Cerebral Circulation
The Cerebral Circulation

Author: Marilyn J. Cipolla

Publisher: Biota Publishing

Published: 2016-07-28

Total Pages: 82

ISBN-13: 1615047239

DOWNLOAD EBOOK

This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

Cerebral Blood Flow and Metabolism
Cerebral Blood Flow and Metabolism

Author: Lars Edvinsson

Publisher:

Published: 2002

Total Pages: 521

ISBN-13: 9780781722599

DOWNLOAD EBOOK

Written and edited by the world's foremost authorities, the Second Edition of this landmark work is a current, comprehensive reference on cerebral blood flow and metabolism. The book covers the entire field in a systematic and coherent way and synthesizes the diverse body of basic science and clinical literature. The reader will gain a complete understanding of the anatomical, physiological, and pharmacological bases of the cerebral circulation, its regulation in health and disease, and the pathophysiological disturbances occurring in cerebrovascular disorders. Coverage includes stimulating discussions of future directions for research and therapeutic intervention.

Cerebral Blood Flow And Metabolism: A Quantitative Approach
Cerebral Blood Flow And Metabolism: A Quantitative Approach

Author: Stephen John Payne

Publisher: World Scientific

Published: 2017-10-06

Total Pages: 467

ISBN-13: 9813220589

DOWNLOAD EBOOK

This book describes the way in which the human brain is supplied with blood and how the brain uses this to provide nutrients, primarily oxygen and glucose, to brain cells in order to maintain healthy brain function. In particular, it focuses on the quantitative nature of blood flow and metabolism. The book covers models of blood flow and metabolism and how these can be measured using a variety of imaging and non-imaging techniques. It also examines how cerebral blood flow is controlled in response to a wide variety of challenges and how it changes with normal physiological variation and in response to a large number of pathological conditions, including stroke and dementia.As the first substantial book for over ten years in a fast-changing field, it highlights how the subject has progressed in the last couple of decades. It tackles the subject in a quantitative way, underlining its importance in both technical and clinical fields. Audiences with a technical or clinical background, especially researchers and postgraduate students in biomedical engineering or medicine, will find this a valuable read.

Handbook of Neurocritical Care
Handbook of Neurocritical Care

Author: Anish Bhardwaj

Publisher: Springer Science & Business Media

Published: 2004-05-25

Total Pages: 345

ISBN-13: 1592597726

DOWNLOAD EBOOK

Neurocritical care as a subspecialty has grown rapidly over the last 20 years with the advent of newer monitoring and diagnostic techniques and therapeutic modalities in a variety of brain and spinal cord injury paradigms. This handbook will serve as a quick reference guide to all health care providers in a neurocritical care setting. Since time is of the essence in the rapid diagnosis and timely therapeutic interventions for these patients, this book provides an algorithmic approach to making a clinical diagnosis using ancillary investigations to confirm the diagnosis and provide appropriate management of acute neurologic diseases. Tables and illustrations help provide a quick and easy bedside reference and give a practical approach to the management of these patients.

Regulation of Tissue Oxygenation, Second Edition
Regulation of Tissue Oxygenation, Second Edition

Author: Roland N. Pittman

Publisher: Biota Publishing

Published: 2016-08-18

Total Pages: 117

ISBN-13: 1615047212

DOWNLOAD EBOOK

This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.

Core Topics in Neuroanaesthesia and Neurointensive Care
Core Topics in Neuroanaesthesia and Neurointensive Care

Author: Basil F. Matta

Publisher: Cambridge University Press

Published: 2011-10-13

Total Pages: 535

ISBN-13: 1139499858

DOWNLOAD EBOOK

Core Topics in Neuroanesthesia and Neurointensive Care is an authoritative and practical clinical text that offers clear diagnostic and management guidance for a wide range of neuroanesthesia and neurocritical care problems. With coverage of every aspect of the discipline by outstanding world experts, this should be the first book to which practitioners turn for easily accessible and definitive advice. Initial sections cover relevant anatomy, physiology and pharmacology, intraoperative and critical care monitoring and neuroimaging. These are followed by detailed sections covering all aspects of neuroanesthesia and neurointensive care in both adult and pediatric patients. The final chapter discusses ethical and legal issues. Each chapter delivers a state-of-the art review of clinical practice, including outcome data when available. Enhanced throughout with numerous clinical photographs and line drawings, this practical and accessible text is key reading for trainee and consultant anesthetists and critical care specialists.