Binding and Linkage

Binding and Linkage

Author: Jeffries Wyman

Publisher: University Science Books

Published: 1990

Total Pages: 358

ISBN-13: 9780935702569

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Ligand-macromolecule interactions are of fundamental importance in the control of biological processes. This book applies the principles of linkage thermodynamics to polyfunctional macromolecular systems under equilibrium conditions, and describes the binding, linkage, and feedback phenomena that lead to control of complex metabolic processes. The first chapter sets out the different processes (conformational changes, changes in state of aggregation, phase changes) involving biological macromolecules which are affected by chemical variables (such as ligands) or physical variables (such as temperature and pressure). The general effects of ligands on micromolecular conformations and interactions are illustrated with specific examples from the respiratory proteins, electron-transport proteins, and nucleic acid binding proteins. Subsequent chapters develop these themes, and describe in detail how the mathematics of regulation and control can be applied to macromolecules in biological system.


Introduction to Macromolecular Binding Equilibria

Introduction to Macromolecular Binding Equilibria

Author: Charles P. Woodbury

Publisher: CRC Press

Published: 2007-11-08

Total Pages: 272

ISBN-13: 1420052993

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Macromolecules in the body form noncovalent associations, such as DNA-protein or protein-protein complexes, that control and regulate numerous cellular functions. Understanding how changes in the concentration and conformation of these macromolecules can trigger physiological responses is essential for researchers developing drug therapies to treat


Author:

Publisher: Delene Kvasnicka

Published:

Total Pages: 652

ISBN-13:

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Protein-Nucleic Acid Interactions

Protein-Nucleic Acid Interactions

Author: Phoebe A. Rice

Publisher: Royal Society of Chemistry

Published: 2008-05-22

Total Pages: 417

ISBN-13: 0854042725

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This book provides both in-depth background and up-to-date information in this area. The chapters are organized by general themes and principles, written by experts who illustrate topics with current findings. Topics covered include: - the role of ions and hydration in protein-nucleic acid interactions - transcription factors and combinatorial specificity - indirect readout of DNA sequence - single-stranded nucleic acid binding proteins - nucleic acid junctions and proteins, - RNA protein recognition - recognition of DNA damage. It will be a key reference for both advanced students and established scientists wishing to broaden their horizons.


Torqueflite A-727 Transmission Handbook HP1399

Torqueflite A-727 Transmission Handbook HP1399

Author: Carl Munroe

Publisher: Penguin

Published: 2003-08-05

Total Pages: 248

ISBN-13: 9781557883995

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This book provides step-by-step instructions for how to modify Chrysler's 904 Torqueflite automatic transmission for drag racing, road racing, and circle racing. Topics include theory of operation, transbrakes/valve bodies, adapters, dissembly, modifications, assembly, adjustments, installation, high horsepower application, and torque converters.


Genetic Engineering of Plants for Crop Improvement

Genetic Engineering of Plants for Crop Improvement

Author: Rup Lal

Publisher: CRC Press

Published: 2020-01-31

Total Pages: 513

ISBN-13: 1351089137

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Genetic Engineering of Plants for Crop Improvement discusses current genetic engineering methods for plants and addresses the commercial opportunities for transgenic plants. Topics covered include Agrobacterium-mediated transformations, the use of electroporation, PEG-mediated transformation, microinjection, the microprojectile bombardment method, and the electrical discharge particle acceleration method. A concise account of the resistance of transgenic plants to insect attack, viral infection, and herbicides has also been provided. Possibilities for genetic manipulation for proteins that have superior nutritional properties are discussed, and a brief account of tests confirming the safety and commercial validity of transgenic plants is included. A valuable source of information for researchers and students in plant biotechnology, plant gene manipulation, molecular biology, and all areas of the life sciences.


Linking Trade and Security

Linking Trade and Security

Author: Vinod K. Aggarwal

Publisher: Springer Science & Business Media

Published: 2012-10-10

Total Pages: 261

ISBN-13: 1461447658

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​The connections between trade and security are hardly new. Analysts and practitioners have clearly recognized this interrelationship since the mercantilist arguments of the 16th and 17th centuries. Despite wishful economic liberal thinking that might prefer to separate the political from the economic, it is widely recognized that trade and security are fundamentally interconnected in the foreign policy of states. Over time, as new forms of trade policy have come into being and the international security environment has evolved, the nexus of these two spheres has grown more complex and scholars have struggled to understand their interconnection This edited volume addresses linkages between trade and security by examining the influence of security factors in driving trade policy measures and the corresponding implications of different types of trade arrangements for international security. Ultimately, the project shows that several elements—traditional economic factors, traditional security factors, and human security factors—can affect the development of trade agreements and unilateral policies, and that trade policies may have both a direct and an indirect effect on traditional and human security. The project focuses on Asia, a region where economics is increasingly important but many security issues still linger unresolved, as a primary setting to test trade linkage theories. It also provides a comparative perspective through examination of how the EU and US have used their trade policies to achieve non-economic goals and how these policies have influenced their security environment. Case studies in this project cover key trade institutions and agreements including the World Trade Organization, the Association of Southeast Asian Nations, ASEAN Plus Three, the East Asia Summit, the Asia-Pacific Economic Cooperation forum, the Shanghai Cooperation Organization, and bilateral preferential trade agreements.