This is a comprehensive and novel text that examines key features that predispose individuals to autoimmune diseases. The first section details the basic mechanism of autoimmunity and examines immunogenetic and environmental factors in autoimmunity. The next section examines autoimmune thyroid disease. The third section takes a look at Type 1 diabetes mellitus. In the final section, authors explain other autoimmune endocrinopathies.
The Autoimmune Diseases comprehensively describes the clinical expressions of all known autoimmune diseases, as well as the experimental bases of autoimmunity and failure of tolerance. The scientific chapters include mechanisms of natural tolerance, the genetic basis of autoimmunity, the significance of apoptosis, the influence of cytokines, environmental influences, and experimental models. The clinical chapters cover autoimmune endocrine deficiencies, insulin-dependent diabetes, rheumatic disorders, neurological diseases, and diseases of the blood, skin, eye, kidney, and liver.
In 1956, three groups independently reported evidence that some thyroid disease appearing spontaneously in humans or experimentally induced in animals are related to autoimmune processes. The interval between these landmark discoveries and the present has witnessed a remarkable and continuing growth of both knowledge and concepts concerning the mechanisms of immune regulation, the pathogenesis of autoimmune thyroid diseases, and their clinical and laboratory manifestations. More importantly knowledge of thyroid autoimmunity has, in many respects, comprised the vanguard of an ever increasing appreciation and understanding of autoimmune diseases in general. On November 24-26 1986, an International Symposium on Thyroid Autoimmunity was held in Pisa. Its purpose was to commemorate the birth of thyroid autoimmunity as a scientific discipline, to summarize current knowledge and concepts in this area, and where possible, to anticipate areas of opportunity for the future - hence the theme of the Symposium, Memories and Perspectives. To open the meeting, the Magnifico Rettore (Chancellor) of the University of Pisa granted special Awards to Dr. Deborah Doniach, Dr. Ivan Roitt, and Dr. Noel R. Rose, who published the first fundamental studies in the field of thyroid autoimmunity, and to Dr. Duncan G. Adams, whose discovery of the long-acting thyroid stimulator (LATS) opened the door to our current understanding of the pathogenesis of Graves' disease. During the meeting thirty plenary lectures were presented.
Interactions between the immune, endocrine and nervous systems seldom appear as main issues in the neurosciences and in immunology. So far this was most likely due to the need to focus on the molecular and cellular bases of single neural, endocrine and immune processes. But hormones, neurotransmitters and neuropeptides can also influence more subtle mechanisms underlying immune cell activity. The contents of this volume aim at listing some aspects which show that not only the bases for neuroendocrine control of more refined mechanisms related to the organization and functioning of the immune systems to exist, but also that the immune system can actively communicate with neuroendocrine structures. The evidence is divided into three categories: - Anatomical, cellular and molecular bases for the exchange of information between immune, endocrine and neural cells, - reciprocal effects between immune and neuroendocrine mechanisms, and - immune-neuroendocrine regulatory circuits. Immunologically triggered neuroendocrine responses can be either beneficial or deleterious for the host. A systematic approach would imply the simultaneous evaluation of neuroendocrine and immune parameters and thus provide the basis for therapeutic interventions based on antagonizing or blocking undesirable effects.
The hypothalamic-pituitary-adrenal axis controls reactions to stress and regulates various body processes such as digestion, the immune system, mood and sexuality, and energy usage. This volume focuses on the role it plays in the immune system and provides substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. - Evidence presented in this book suggests that the nervous, endocrine, and immune systems form the Neuroendoimmune Supersystem, which integrates all the biological functions of higher organisms both in health and disease for their entire life cycle - Contributors include both the scientists who initiated the work on the HPA axis and on the autonomic nervous system, and those who joined the field later
From the author of the New York Times bestseller The Autoimmune Solution, a comprehensive, accessible overview of thyroid problems that will help you learn to identify the warning signs and finally take back your health. Are you exhausted all the time, plagued by brain fog, and unable to lose weight? Do you struggle with insomnia, panic attacks, and tremors? But does your doctor insist that your labs are normal, and that you just need to eat less and exercise more? As anyone who has been there knows, nothing is more frustrating, stressful, and emotionally draining than feeling unwell and being told you're fine by the very person who is supposed to heal you. The truth is, your symptoms could be triggered by a thyroid disorder—the hidden cause behind a wide array of health problems that can threaten to ruin your life. Thyroid dysfunctions like Hashimoto's disease, hypothyroidism, and hyperthyroidism affect at least 20 million Americans and yet conventional medicine frequently misses the diagnosis. The scariest part? Most doctors won't even order thyroid tests unless you specifically ask. Now, in The Thyroid Connection, Dr. Amy Myers teaches you how to take your health into your own hands. Dr. Myers, originally misdiagnosed herself, understands the struggles of thyroid dysfunction firsthand. Fortunately, she also knows how achievable recovery and well-being are, and just how to get you there. In The Thyroid Connection, you'll discover: How to work with your doctor to get the correct diagnosis What blood tests to ask for, as well as what they mean How to find the right type and dose of supplemental thyroid hormone for you The role of gut health, diet, toxins, infections, and stress in thyroid dysfunction A complete 28-day plan to jumpstart your health and reverse your thyroid symptoms Complete with advice on diet and nutrition, supplements, exercise, stress relief, and sleep, The Thyroid Connection is the ultimate roadmap back to your happiest, healthiest self.
Dr. Edelson discusses the most common types of autoimmune diseases, outlining their symptoms, causes, and risk factors. He describes his own revolutionary program for treating the root of all autoimmune disorders--without drugs--providing readers with new hope for getting back on the road to better health.
From 11 to 15 July 1977 about 60 physiologists, endo crinologists, ecologists and other biologists from 14 countries convened at the University Montpellier for a symposium on Environmental Endocrinology. This meet ing was organized as a Satellite Symposium of the 27th International Congress of Physiological Sciences, Paris, 18-23 July 1977. This volume is a record of the com munications presented at the symposium. The objectives of the program were to examine the role of the endocrine system in a wide spectrum of adjustments and adaptations to changes in environmental conditions by various spe cies of animals, including man, and to promote an ex change of ideas among investigators who have approached these functions from diverse aspects. The diversity of the information and ideas communicated is great. Of necessity, they represent only an extremely modest se lection of the many facets of endocrine function in the interaction of animals with their environments. Be yond the usefulness of the communications individually, we hope that they collectively demonstrate the substan tial heuristic value of the concept of environmental endocrinology as it was perceived by the participants. We acknowledge gratefully the kindness and sympathy of Professor Jaques ROUZAUD, President of the University of Montpellier II, for his generous extension of the hospitality of the University to the Symposium. We are most grateful to Mrs. Monique VIEU who effected so well the secretarial organization of the Sympos.
Also the 3rd edition of "Dermatology" covers all the classical and related fields of dermatology, providing a wealth of information on diagnostic methods, clinical features, pathophysiology, and differential diagnosis. About 950 excellent photos and diagrams help the reader become acquainted with the immense variety of dermatological diseases. The contents of all chapters have been updated. New chapters have been included covering numerous subjects, e.g. dermatopathology, sonography, disorders of chromosomal instability and defective DNA repair, aging skin, sport dermatology, aesthetic therapy. The book is a must for every doctor confronted with dermatological problems.
