Maps

Maps

Author: Edward Augustus Freeman

Publisher:

Published: 1882

Total Pages: 154

ISBN-13:

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Atlas of the Human Brain

Atlas of the Human Brain

Author: Juergen K Mai

Publisher: Academic Press

Published: 2015-12-02

Total Pages: 458

ISBN-13: 0128028017

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The fourth edition of Atlas of the Human Brain presents the anatomy of the brain at macroscopic and microscopic levels, featuring different aspects of brain morphology and topography. This greatly enlarged new edition provides the most detailed and accurate delineations of brain structure available. It includes features which assist in the new fields of neuroscience – functional imaging, resting state imaging and tractography. Atlas of the Human Brain is an essential guide to those working with human brain imaging or attempting to relate their observations on experimental animals to humans. Totally new in this edition is the inclusion of Nissl plates with delineation of cortical areas (Brodmann's areas), the first time that these areas have been presented in serial histological sections. - Winner of the 2016 British Medical Association Award for Best Illustrated Text and previous edition winner of the Award of Excellence from the American Association of Publishers - The contents of the Atlas of the brain in MNI stereotaxic space has been extensively expanded from 143 pages, showing 69 levels through the hemisphere, to 314 pages representing 99 levels - In addition to the fiber-stained (myelin) plates, we now provide fifty new (Nissl) plates covering cytoarchitecture. These are interdigitated within the existing myelin plates of the stereotaxic atlas - All photographic plates now represent the complete hemisphere - All photographs of the cell- and fiber-stained sections have been transformed to fit the MNI-space - Major fiber tracts are identified in the fiber-stained sections - In the Nissl plates cortical delineations (Brodmann's areas) are provided for the first time - The number of diagrams increased to 99. They were now generated from the 3D reconstruction of the hemisphere registered to the MNI- stereotaxic space. They can be used for immediate comparison between our atlas and experimental and clinical imaging results - Parts of cortical areas are displayed at high magnification on the facing page of full page Nissl sections. Images selected highlight those areas which are thought to correspond with those published by von Economo and Koskinas (1925) - A novel way of depicting cortical areal pattern is used: The cortical cytoarchitectonic ribbon is unfolded and presented linearly. This linear representation of the cortex enables the comparison of different interpretations of cortecal areas and allows mapping of activation sites - Low magnification diagrams in the horizontal (axial) and sagittal planes are included, calculated from the 3D model of the atlas brain


Antisense Drug Technology

Antisense Drug Technology

Author: Stanley T. Crooke

Publisher: CRC Press

Published: 2007-07-25

Total Pages: 858

ISBN-13: 0849387957

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Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research. Interpreting lessons learned from the clinical trials of first generation drugs, the book evaluates the technology as a whole and offers new directions and avenues of research and development. Divided into five parts, the book begins with a thorough introduction to the mechanism of antisense drug action including the RNase H mechanism, small RNA silencing pathways, and the potential therapeutics of splice switching oligonucleotides. Leading researchers demonstrate the basics of oligonucleotide therapeutics in part two by delineating medicinal chemistry, pharmacokinetics, and delivery routes such as liposomal formulations for nucleic acid delivery. Part three details hybridization based drugs and considers the dramatic advances represented by 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA drugs. Other chemical classes of drugs and mechanisms of action are described in part four with further discussions on improving the second generation antisense drugs. The final part delves deeply into therapeutic applications. Contributing authors examine the potential of antisense drugs for the alleviation of cardiovascular diseases, metabolic diseases, inflammatory diseases, cancer, neurological disorders, and immune modulation. Presenting a highly detailed, lucid discussion of the remarkable advances in the field, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition provides the platform for researchers to continue to aggressively pursue the great opportunity represented by this exciting technology.


Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease

Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease

Author: Roger N. Rosenberg

Publisher: Academic Press

Published: 2020-06-24

Total Pages: 1013

ISBN-13: 0128139560

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Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Sixth Edition: Volume One, provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to neurologic and psychiatric disease. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Every chapter has been thoroughly revised or newly commissioned to reflect the latest scientific and medical advances by an international team of leading scientists and clinicians. The contents have been expanded to include disorders for which a genetic basis has been recently identified, together with abundant original illustrations that convey and clarify the key points of the text in an attractive, didactic format. Comprehensive coverage of the neurogenetic foundation of neurological and psychiatric disease Provides a detailed introduction on both the clinical and basic research implications of molecular and genetics surrounding the brain Includes new chapters on molecular genomics, CRISPR and the most recent updates in molecular genetics


Seeing Red

Seeing Red

Author: Suzanne Hindmarch

Publisher: University of Toronto Press

Published: 2018-06-01

Total Pages: 390

ISBN-13: 1487510314

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What does it mean to think of HIV/AIDS policy in a critical manner? Seeing Red offers the first critical analysis of HIV/AIDS policy in Canada. Featuring the diverse experiences of people living with HIV, this collection highlights various perspectives from academics, activists, and community workers who look ahead to the new and complex challenges associated with HIV/AIDS and Canadian society. In addition to representing a diversity of voices and perspectives, Seeing Red reflects on historical responses to HIV/AIDS in Canada. Among the specific issues addressed are the over-representation of Indigenous peoples among those living with HIV, the criminalization of HIV, and barriers to health and support services, particularly as experienced by vulnerable and marginalized populations. The editors and contributors seek to show that Canada has been neither uniquely compassionate nor proactive when it comes to supporting those living with HIV/AIDS. Instead, this remains a critical area of public policy, one fraught with challenges as well as possibilities.


Aircraft Accident Report

Aircraft Accident Report

Author: United States. National Transportation Safety Board

Publisher:

Published: 2007

Total Pages: 92

ISBN-13:

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On February 16, 2005, about 0913 mountain standard time, a Cessna Citation 560, N500AT, operated by Martinair, Inc., for Circuit City Stores, Inc., crashed about 4 nautical miles east of Pueblo Memorial Airport, Pueblo, Colorado, while on an instrument landing system approach to runway 26R. The two pilots and six passengers on board were killed, and the airplane was destroyed by impact forces and postcrash fire. The flight was operating under the provisions of 14 Code of Federal Regulations Part 91 on an instrument flight rules flight plan. Instrument meteorological conditions prevailed at the time of the accident. The National Transportation Safety Board determines that the probable cause of this accident was the flight crew's failure to effectively monitor and maintain airspeed and comply with procedures for deice boot activation on the approach, which caused an aerodynamic stall from which they did not recover. Contributing to the accident was the Federal Aviation Administration's failure to establish adequate certification requirements for flight into icing conditions, which led to the inadequate stall warning margin provided by the airplane's stall warning system.