More than any other branch of organic chemistry, synthesis has improved our understanding of the structure, dynamics, and transition of molecules. The availability of sophisticated tools and new techniques has made organic synthesis more challenging than ever for those in the field. This updated edition of the 1970 work highlights significant and intriguing synthetic achievements: their ingenuity in design, extent of stereochemical control, new reactions, and new reagents. Approximately 100 examples illustrate various aspects of organic synthesis, with particular emphasis on bond-making and bond-breaking, dissymetry, conformation, and stereoelectric considerations. Each describes the synthesis of a natural product or of an unusual or strained molecule. Numerous flow sheets and perspective structural formulas illustrate the force of arguments predicting the stereochemical outcome of important steps. Also included is a type-transformation index which highlights some less common reactions.
The view of organic synthesis as "a concentrated expression of predictive ability and creative capacity" was advocated in the early 1950s. A concise and readable account of the role of synthesis in modern science, Organic Synthesis: The Science Behind the Art presents the general ideology of pursuits in the area of organic synthesis, and examines the methodologies that have evolved in the search for solutions to synthetic problems. This unique book details outstanding achievements of modern organic synthesis, not only for their scientific merits, but also for the aesthetic appeal of the target molecules chosen and the intrinsic beauty of the solutions to the problems posed. By judicious selection of data covering the main areas of synthetic explorations, this book serves to illustrate both the evolution of well-known approaches as well as recently emerged trends most likely to determine the future development of organic synthesis. Special attention is given to the consideration of principles of molecular design in promising and challenging areas of current research. Primarily aimed at advanced undergraduate and graduate students, Organic Synthesis: The Science Behind the Art will also be of interest to teachers, researchers and anyone requiring an introduction to the problems of organic synthesis.
This is the companion book to the former CHF traveling exhibit by the same name. "This multifaceted portrait of an extraordinary human being, teacher, and consummate organic chemist should inspire more young persons to pursue scientific careers, provide chemists with deep insight into the creative mind of a 'legendary architect of molecules,' and enhance the public's understanding of chemistry and its research methods." - Journal of Chemical Education.
This title provides a forum for investigators to discuss their approach to the science and art of organic synthesis in a unique way. There are stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners.
Intended for students of intermediate organic chemistry, this text shows how to write a reasonable mechanism for an organic chemical transformation. The discussion is organized by types of mechanisms and the conditions under which the reaction is executed, rather than by the overall reaction as is the case in most textbooks. Each chapter discusses common mechanistic pathways and suggests practical tips for drawing them. Worked problems are included in the discussion of each mechanism, and "common error alerts" are scattered throughout the text to warn readers about pitfalls and misconceptions that bedevil students. Each chapter is capped by a large problem set.
Organic Synthesis: State of the Art 2017-2019 is a convenient, concise reference that summarizes the most important current developments in organic synthesis, from functional group transformation to heteraromatic construction and complex natural product synthesis. The eighth volume in the esteemed State of the Art series, the book compiles two years of Taber's popular weekly column "Organic Chemistry Highlights". The series is an invaluable resource, leading chemists quickly and easily to the most significant developments in the field. The book is divided into two sections: the first three-quarters focuses on twenty broad areas of organic synthesis, from C-C bond formation to aromatic substitution, with the most important new developments in each area. Journal references are included in the text. The last quarter of the book is devoted to the most significant total syntheses reported in the period, with an analysis of the strategy for each, and discussions of pivotal transformations. Cumulative author and reaction/transformation indexes covering all eight volumes in this series conclude the book. This volume is an ideal tool both for practicing chemists and for students, offering a rich source of information and suggesting fruitful pathways for futureinvestigation.
The stepping-stone text for students with a preliminary knowledge of organic chemistry looking to move into organic synthesis research and graduate-level coursework Organic synthesis is an advanced but important field of organic chemistry, however resources for advanced undergraduates and graduate students moving from introductory organic chemistry courses to organic synthesis research are scarce. Introduction to Strategies for Organic Synthesis is designed to fill this void, teaching practical skills for making logical retrosynthetic disconnections, while reviewing basic organic transformations, reactions, and reactivities. Divided into seven parts that include sections on Retrosynthesis and Protective Groups; Overview of Organic Transformations; Synthesis of Monofunctional Target Molecules; Synthesis of Target Molecules with Two Functional Groups; Synthesis of Aromatic Target Molecules; Synthesis of Compounds Containing Rings; and Predicting and Controlling Stereochemistry, the book covers everything students need to successfully perform retrosynthetic analyses of target molecule synthesis. Starting with a review of functional group transformations, reagents, and reaction mechanisms, the book demonstrates how to plan a synthesis, explaining functional group analysis and strategic disconnections. Incorporating a review of the organic reactions covered, it also demonstrates each reaction from a synthetic chemist's point of view, to provide students with a clearer understanding of how retrosynthetic disconnections are made. Including detailed solutions to over 300 problems, worked-through examples and end-of-chapter comprehension problems, Introduction to Strategies for Organic Synthesis serves as a stepping stone for students with an introductory knowledge of organic chemistry looking to progress to more advanced synthetic concepts and methodologies.
The first in a new series, this book provides chemists an effective, much-needed way to stay abreast of recent developments in organic synthesis. The 103 articles review the leading synthetic procedures developed from 2003 - 2005, discussing their significance and their applications. More than 100 reactions are covered, including Heterocycle Construction by Grubbs Metathesis, Enantioselective C-C Bond Construction, and Organic Reactions in Ionic Liquids.
Organic Synthesis, Fourth Edition, provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, to provide them with critical working knowledge of basic reactions, stereochemistry and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature. In the Fourth Edition, the organization of the book has been improved to better serve students and professors and accommodate important updates in the field. The first chapter reviews basic retrosynthesis, conformations and stereochemistry. The next three chapters provide an introduction to and a review of functional group exchange reactions; these are followed by chapters reviewing protecting groups, oxidation and reduction reactions and reagents, hydroboration, selectivity in reactions. A separate chapter discusses strategies of organic synthesis, and he book then delves deeper in teaching the reactions required to actually complete a synthesis. Carbon-carbon bond formation reactions using both nucleophilic carbon reactions are presented, and then electrophilic carbon reactions, followed by pericyclic reactions and radical and carbene reactions. The important organometallic reactions have been consolidated into a single chapter. Finally, the chapter on combinatorial chemistry has been removed from the strategies chapter and placed in a separate chapter, along with valuable and forward-looking content on green organic chemistry, process chemistry and continuous flow chemistry. Throughout the text, Organic Synthesis, Fourth Edition utilizes Spartan-generated molecular models, class tested content, and useful pedagogical features to aid student study and retention, including Chapter Review Questions, and Homework Problems. A full Solutions Manual is also available online for qualified instructors, to support teaching. - Winner, 2018 Textbook Excellence Award (Texty) from the Textbook and Academic Authors Association - Fully revised and updated throughout, and organized into 19 chapters for a more cogent and versatile presentation of concepts - Includes reaction examples taken from literature research reported between 2010-2015 - Features new full-color art and new chapter content on process chemistry and green organic chemistry - Offers valuable study and teaching tools, including Chapter Review Questions and Homework Problems for students; Solutions Manual for qualified course instructors
