New Drug Development for Known and Emerging Viruses
New Drug Development for Known and Emerging Viruses

Author: Helga Rübsamen-Schaeff

Publisher: John Wiley & Sons

Published: 2021-11-30

Total Pages: 530

ISBN-13: 3527810706

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Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronoavirus-2 causing the present pandemic. New Drug Development for Known and Emerging Viruses describes the discovery and development process for antiviral agents for different classes of viruses and targets based on the experiences from the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV, and VZV). It covers the properties and potential of 20 classes of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses. Covers the entire field of antiviral drug discovery and development Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2 Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angle Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues New Developments in Antiviral Drugs is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the ;pharmaceutical industry and public health agencies.

Arthropod Borne Diseases
Arthropod Borne Diseases

Author: Carlos Brisola Marcondes

Publisher: Springer

Published: 2016-11-09

Total Pages: 642

ISBN-13: 3319138847

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Arthropod borne diseases cause enormous morbidity and mortality in most countries, mostly in those situated in tropical areas, but also in temperate regions. This book provides organized information on all arthropod related diseases, to prevent suffering and deaths, for medical students and professionals. Since arthropod borne diseases are present in many regions of the world and can even surprise professionals and lays in non-endemic regions, like malaria in UK and Canada, the author and its many expert collaborators are sure that it will be essential in all hospitals, clinics and medical libraries around the world. As arthropod borne diseases of domesticated animals are very numerous and in some cases related to human diseases, they are also included in the book.

The New Public Health
The New Public Health

Author: Theodore H. Tulchinsky

Publisher: Academic Press

Published: 2014-03-26

Total Pages: 911

ISBN-13: 012415767X

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The New Public Health has established itself as a solid textbook throughout the world. Translated into 7 languages, this work distinguishes itself from other public health textbooks, which are either highly locally oriented or, if international, lack the specificity of local issues relevant to students' understanding of applied public health in their own setting. This 3e provides a unified approach to public health appropriate for all masters' level students and practitioners—specifically for courses in MPH programs, community health and preventive medicine programs, community health education programs, and community health nursing programs, as well as programs for other medical professionals such as pharmacy, physiotherapy, and other public health courses. - Changes in infectious and chronic disease epidemiology including vaccines, health promotion, human resources for health and health technology - Lessons from H1N1, pandemic threats, disease eradication, nutritional health - Trends of health systems and reforms and consequences of current economic crisis for health - Public health law, ethics, scientific d health technology advances and assessment - Global Health environment, Millennium Development Goals and international NGOs

Arthropod Cell Culture Systems
Arthropod Cell Culture Systems

Author: Karl Maramorosch

Publisher: CRC Press

Published: 1994-06-03

Total Pages: 250

ISBN-13: 9780849376429

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Invertebrate cell culture is increasingly being used in various areas of biological research. Research in cellular biology and pathology that previously depended primarily on in vitro investigations of vertebrate animal cell systems is now being conducted using invertebrate cells. Specialists and pioneers from the United States, Japan, Switzerland, Slovakia, and China have presented original contributions to create a well-balanced cross-section of current developments. Topics discussed include the preparation of cell culture media; cultivation of mosquito, lepidopteran, grasshopper, and tick cells; the application of such cells to mammalian and plant virus research; and diverse applications in medicine, biology, and agriculture. A special chapter devoted to the work of Japanese cell culture pioneers is also featured. All chapters are supported by tables, photographs, and up-to-date bibliographies.

The Togaviridae and Flaviviridae
The Togaviridae and Flaviviridae

Author: Sondra Schlesinger

Publisher: Springer Science & Business Media

Published: 2013-03-09

Total Pages: 464

ISBN-13: 1475707851

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The publication of this volume of The Viruses entitled The Togaviridae and Flaviviridae comes at an appropriate time. The structure and rep lication strategies of these viruses are now known to be sufficiently di verse to warrant the removal of flaviviruses from the Togaviridae family and establish them as an independent family. Flaviviridae have a special place in the history of virology. The prototype virus-yellow fever virus was the first virus to be identified as the cause of a human disease. Some of the history of this discovery is described in Chapter 1 of this volume; in Chapter 10 the complete sequence of the RNA genome of the virus is presented. This sequence not only defines the primary structure of the viral proteins, it also clarifies the mechanism of translation of the fla vivirus genome. Knowledge of the sequence of the structural proteins of these viruses represents an important step in the potential goal of using purified flavivirus glycoproteins as vaccines. Many of the chapters in this volume focus on the structure and replication of the Togaviridae. These viruses have provided valuable models for studies in cell biology, partic ularly with regard to the cotranslational and posttranslational steps re quired for the synthesis and localization of membrane glycoproteins. Fur thermore, Togaviridae have been pivotal in our growing understanding of how enveloped viruses enter and exit from cells. The broad outlines of the structure and gene expression of Togavir idae and Flaviviridae are known, but important questions remain.

Viruses in Foods
Viruses in Foods

Author: Sagar Goyal

Publisher: Springer Science & Business Media

Published: 2007-01-15

Total Pages: 355

ISBN-13: 0387292519

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This is the first book to focus entirely on viruses in foods. It collates information on the occurrence, detection, transmission, and epidemiology of viruses in various foods. Although methods for bacterial detection in food are available, methods for detection of viruses in food, with the exception of shellfish, are not available. It is important, therefore, to develop methods for direct examination of food for viruses and to explore alternate indicators that can accurately reflect the virological quality of food. This book addresses these issues along with strategies for the prevention and control of viral contamination of food.

Sustaining Global Surveillance and Response to Emerging Zoonotic Diseases
Sustaining Global Surveillance and Response to Emerging Zoonotic Diseases

Author: National Research Council

Publisher: National Academies Press

Published: 2010-01-24

Total Pages: 339

ISBN-13: 0309137349

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H1N1 ("swine flu"), SARS, mad cow disease, and HIV/AIDS are a few examples of zoonotic diseases-diseases transmitted between humans and animals. Zoonotic diseases are a growing concern given multiple factors: their often novel and unpredictable nature, their ability to emerge anywhere and spread rapidly around the globe, and their major economic toll on several disparate industries. Infectious disease surveillance systems are used to detect this threat to human and animal health. By systematically collecting data on the occurrence of infectious diseases in humans and animals, investigators can track the spread of disease and provide an early warning to human and animal health officials, nationally and internationally, for follow-up and response. Unfortunately, and for many reasons, current disease surveillance has been ineffective or untimely in alerting officials to emerging zoonotic diseases. Sustaining Global Surveillance and Response to Emerging Zoonotic Diseases assesses some of the disease surveillance systems around the world, and recommends ways to improve early detection and response. The book presents solutions for improved coordination between human and animal health sectors, and among governments and international organizations. Parties seeking to improve the detection and response to zoonotic diseases-including U.S. government and international health policy makers, researchers, epidemiologists, human health clinicians, and veterinarians-can use this book to help curtail the threat zoonotic diseases pose to economies, societies, and health.

Tropical Medicine Notebook
Tropical Medicine Notebook

Author: Philippa C. Matthews

Publisher: Oxford University Press

Published: 2017-07-13

Total Pages: 224

ISBN-13: 0191057673

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The Tropical Medicine Notebook is a new concept in providing a concise overview of the key topics in tropical medicine, using short notes, diagrams, maps, and tables to present the material in an accessible, engaging, memorable, and interesting way. The format is generally a page per topic, with division of each page into subsections by boxes to make it easy to find the relevant information. Cross-referencing is provided to allow quick linking between relevant sections of the book. Providing the key information in bite-size chunks, the Tropical Medicine Notebook is a useful companion to more comprehensive texts. Divided into eight sections; the first five cover infections caused by bacteria, viruses, fungi, protozoa and helminths, followed by a further three which present the topics of vector biology, disease syndromes and envenomation. Where relevant, the section is prefaced by a classification system to provide a logical overview, helping with assimilation of information and highlighting important relationships between organisms. It is an ideal learning and revision guide for students or trainees in infection, microbiology, and tropical medicine, as well as being a useful reference resource for healthcare and laboratory staff across the wide range of disciplines to which infection may present.

Rapid Virus Diagnosis
Rapid Virus Diagnosis

Author: P. S. Gardner

Publisher: Butterworth-Heinemann

Published: 2014-06-28

Total Pages: 336

ISBN-13: 1483192172

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Rapid Virus Diagnosis: Application of Immunofluorescence presents developments in immunofluorescence as a technique for the diagnosis of virus infections. It discusses the effective and rapid methods for the diagnosis of virus infections. It addresses the application of fluorescent antibody techniques to the diagnosis and the investigation of virus infections and the assessment of their value both to the clinician and to the virologist. Some of the topics covered in the book are the fluorescence microscopy; nature of fluorescence; filter systems; transmitted light microscopy; interference filters for transmitted light microscopy; lamp centration and alignment of microscope; contrast-fluorescence condensers; photomicrography; and choice of microscope. The culture of viruses for production of antiserum is fully covered. The selection of cell lines or tissues for virus culture is discussed in detail. The text describes in depth the fluorescent antibody staining techniques. The preparation of specimens from respiratory infections is presented completely. A chapter is devoted to the respiratory syncytial virus. Another section focuses on the analysis influenza virus, paramyxoviruses, and picornaviruses. The book can provide useful information to doctors, virologists, students, and researchers.