Applying Systems Thinking to Regenerative Medicine

Applying Systems Thinking to Regenerative Medicine

Author: National Academies of Sciences, Engineering, and Medicine

Publisher:

Published: 2021-12-26

Total Pages: 170

ISBN-13: 9780309151825

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Regenerative medicine products, which are intended to repair or replace damaged cells or tissues in the body, include a range of therapeutic approaches such as cell- and gene-based therapies, engineered tissues, and non-biologic constructs. The current approach to characterizing the quality of a regenerative medicine product and the manufacturing process often involves measuring as many endpoints as possible, but this approach has proved to be inadequate and unsustainable. The Forum on Regenerative Medicine of the National Academies of Sciences, Engineering, and Medicine convened experts across disciplines for a 2-day virtual public workshop to explore systems thinking approaches and how they may be applied to support the identification of relevant quality attributes that can help in the optimization of manufacturing and streamline regulatory processes for regenerative medicine. A broad array of stakeholders, including data scientists, physical scientists, industry researchers, regulatory officials, clinicians, and patient representatives, discussed new advances in data acquisition, data analysis and theoretical frameworks, and how systems approaches can be applied to the development of regenerative medicine products that can address the unmet needs of patients. This publication summarizes the presentation and discussion of the workshop.


Thinking in Systems

Thinking in Systems

Author: Donella Meadows

Publisher: Chelsea Green Publishing

Published: 2008-12-03

Total Pages: 242

ISBN-13: 1603581480

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The classic book on systems thinking—with more than half a million copies sold worldwide! "This is a fabulous book... This book opened my mind and reshaped the way I think about investing."—Forbes "Thinking in Systems is required reading for anyone hoping to run a successful company, community, or country. Learning how to think in systems is now part of change-agent literacy. And this is the best book of its kind."—Hunter Lovins In the years following her role as the lead author of the international bestseller, Limits to Growth—the first book to show the consequences of unchecked growth on a finite planet—Donella Meadows remained a pioneer of environmental and social analysis until her untimely death in 2001. Thinking in Systems is a concise and crucial book offering insight for problem solving on scales ranging from the personal to the global. Edited by the Sustainability Institute’s Diana Wright, this essential primer brings systems thinking out of the realm of computers and equations and into the tangible world, showing readers how to develop the systems-thinking skills that thought leaders across the globe consider critical for 21st-century life. Some of the biggest problems facing the world—war, hunger, poverty, and environmental degradation—are essentially system failures. They cannot be solved by fixing one piece in isolation from the others, because even seemingly minor details have enormous power to undermine the best efforts of too-narrow thinking. While readers will learn the conceptual tools and methods of systems thinking, the heart of the book is grander than methodology. Donella Meadows was known as much for nurturing positive outcomes as she was for delving into the science behind global dilemmas. She reminds readers to pay attention to what is important, not just what is quantifiable, to stay humble, and to stay a learner. In a world growing ever more complicated, crowded, and interdependent, Thinking in Systems helps readers avoid confusion and helplessness, the first step toward finding proactive and effective solutions.


Systems Thinking in Medicine and New Drug Discovery

Systems Thinking in Medicine and New Drug Discovery

Author: Robert E. Smith

Publisher: Cambridge Scholars Publishing

Published: 2018-12-17

Total Pages: 632

ISBN-13: 1527523667

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Total Quality Management (TQM) and systems thinking are being used to improve all aspects of human health. This first book in a two-volume set details how the healthcare community is working with patients and their caregivers to improve healthcare and reduce its costs. Systems-based thinking encourages us to work together to look at the effects of new drugs on entire systems and not just single molecular targets. It also leads us to a better understanding of genetics and epigenetics, as well as the deep ecology of the human body. The healthcare community is developing targeted therapies that stimulate our own bodies to cure ourselves and eliminate the need for animal testing. This book will appeal to specialists, who will find recommendations on safer materials for 3D bioprinting and ways to analyze dietary supplements for toxic contaminants, and physicians, pharmacists and non-professionals, who will learn the important different ways that dietary supplements and prescription drugs are developed, sold and marketed.


New Approaches to Economic Challenges Systemic Thinking for Policy Making The Potential of Systems Analysis for Addressing Global Policy Challenges in the 21st Century

New Approaches to Economic Challenges Systemic Thinking for Policy Making The Potential of Systems Analysis for Addressing Global Policy Challenges in the 21st Century

Author: OECD

Publisher: OECD Publishing

Published: 2020-02-27

Total Pages: 173

ISBN-13: 9264494561

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In Systemic Thinking for Policy Making world experts from the OECD and International Institute for Applied Systems Analysis (IIASA) pool their expertise and experience to propose new approaches to analysing the interconnected trends and issues shaping today’s and tomorrow’s world.


Regenerative Medicine Technology

Regenerative Medicine Technology

Author: Sean V. Murphy

Publisher: CRC Press

Published: 2016-11-30

Total Pages: 350

ISBN-13: 1315354152

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Miniaturization in the fields of chemistry and molecular biology has resulted in the "lab-on-a-chip." Such systems are micro-fabricated devices capable of handling extremely small fluid volumes facilitating the scaling of single or multiple lab processes down to a microchip-sized format. The convergence of lab-on-a-chip technology with the field of cell biology facilitated the development of "organ-on-a-chip" systems. Such systems simulate the function of tissues and organs, having the potential to bypass some cell and animal testing methods. These technologies have generated high interest as applications for disease modeling and drug discovery. This book, edited by Drs. Sean Murphy and Anthony Atala, provides a comprehensive coverage of the technologies that have been used to develop organ-on-a-chip systems. Known leaders cover the basics to the most relevant and novel topics in the field, including micro-fabrication, 3D bio-printing, 3D cell culture techniques, biosensor design and microelectronics, micro-fluidics, data collection, and predictive analysis. The book describes specific tissue types amenable for disease modeling and drug discovery applications. Lung, liver, heart, skin and kidney "on-a-chip" technologies are included as well as a progress report on designing an entire "body-on-a-chip" system. Additionally, the book covers applications of various systems for modeling tissue-specific cancers, metastasis, and tumor microenvironments; and provides an overview of current and potential applications of these systems to disease modeling, toxicity testing, and individualized medicine.


Biotechnology Annual Review

Biotechnology Annual Review

Author: M. Raafat El-Gewely

Publisher: Elsevier

Published: 2008-10-03

Total Pages: 490

ISBN-13: 0080888089

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Biotechnology is a diverse, complex, and rapidly evolving field. Students and experienced researchers alike face the challenges of staying on top of developments in their field of specialty and maintaining a broader overview of the field as a whole. This latest volume of Biotechnology Annual Review comprises expert reviews on a diverse range of topics, ranging from gene expression microarray analysis to the use of ethnomedicines and ethnomedicinal phytophores to treat herpes viruses. Such a diverse range of review topics will keep biotechnologists of all levels up-to-date on the latest in the vast field of biotechnology and deepen their understanding of the many facets of the field as a whole. - More than 150 figures elucidate and reinforce key points - Inclusion of reviews of such hot-topics as arginine methylation in health and disease - Wide variety of coverage keeps biotechnologists up-to-date on many facets of the field


Regenerative Rehabilitation

Regenerative Rehabilitation

Author: Sarah M. Greising

Publisher: Springer Nature

Published: 2022-06-01

Total Pages: 462

ISBN-13: 3030958841

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This contributed volume presents the current state of research on regenerative rehabilitation across a broad range of neuro- and musculoskeletal tissues. At its core, the primary goal of regenerative rehabilitation is to restore function after damage to bones, skeletal muscles, cartilage, ligaments/tendons, or tissues of the central and peripheral nervous systems. The authors describe the physiology of these neuro- and musculoskeletal tissue types and their inherent plasticity. The latter quality is what enables these tissues to adapt to mechanical and/or chemical cues to improve functional capacity. As a result, readers will learn how regenerative rehabilitation exploits that quality, to trigger positive changes in tissue function. Combining basic, translational, and clinical aspects of the topic, the book offers a valuable resource for both scientists and clinicians in the regenerative rehabilitation field.


Biodegradable Systems in Tissue Engineering and Regenerative Medicine

Biodegradable Systems in Tissue Engineering and Regenerative Medicine

Author: Rui L. Reis

Publisher: CRC Press

Published: 2004-11-29

Total Pages: 590

ISBN-13: 0203491238

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Conventional materials technology has yielded clear improvements in regenerative medicine. Ideally, however, a replacement material should mimic the living tissue mechanically, chemically, biologically and functionally. The use of tissue-engineered products based on novel biodegradable polymeric systems will lead to dramatic improvements in health


Regenerative Pharmacology

Regenerative Pharmacology

Author: George J. Christ

Publisher: Cambridge University Press

Published: 2013-04-15

Total Pages: 361

ISBN-13: 0521899494

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A state-of-the-art primer on the role of pharmacological sciences in regenerative medicine, for advanced students, postdoctoral fellows, and researchers.


The Systems View of Life

The Systems View of Life

Author: Fritjof Capra

Publisher: Cambridge University Press

Published: 2014-04-10

Total Pages: 513

ISBN-13: 1107011361

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The first volume to integrate life's biological, cognitive, social, and ecological dimensions into a single, coherent framework.