Gene Drives on the Horizon
Gene Drives on the Horizon

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2016-08-28

Total Pages: 231

ISBN-13: 0309437873

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Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.

A Strategic Vision for Department of Energy Environmental Quality Research and Development
A Strategic Vision for Department of Energy Environmental Quality Research and Development

Author: National Research Council

Publisher: National Academies Press

Published: 2001-11-01

Total Pages: 182

ISBN-13: 0309075602

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The National Academies' National Research Council undertook this study in response to a request from the Under Secretary of Energy to provide strategic advice on how the Department of Energy could improve its Environmental Quality R&D portfolio. The committee recommends that DOE develop strategic goals and objectives for its EQ business line that explicitly incorporate a more comprehensive, long-term view of its EQ responsibilities. For example, these goals and objectives should emphasize long-term stewardship and the importance of limiting contamination and materials management problems, including the generation of wastes and contaminated media, in ongoing and future DOE operations.

Sustainability Indicators
Sustainability Indicators

Author: Tomás Hák

Publisher: Island Press

Published: 2012-09-26

Total Pages: 443

ISBN-13: 1597266280

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While the concept of sustainability has been widely embraced, it has been only vaguely defined and is exceedingly difficult to measure. Sustainability indicators are critical to making the broad concept of sustainability operational by providing specific measures by which decision makers and the public can judge progress. Sustainability Indicators defines the present state of the art in indicator development. It presents a comprehensive assessment of the science behind various indicators, while placing special emphasis on their use as communications tools. The contributors draw on their experience as academics and practitioners to describe the conceptual challenges to measuring something as complex as sustainability at local, regional, national, and global scales. The book also reviews existing indicators to assess how they could be better employed, considering which indicators are overused and which have been underutilized. Sustainability Indicators will help planners and policy makers find indicators that are ready for application and relevant to their needs, and will help researchers identify the unresolved issues where progress is most urgently needed. All readers will find advice as to the most effective ways to use indicators to support decision making.

Science and Technology for Environmental Cleanup at Hanford
Science and Technology for Environmental Cleanup at Hanford

Author: National Research Council

Publisher: National Academies Press

Published: 2001-11-23

Total Pages: 192

ISBN-13: 0309075963

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The Hanford Site was established by the federal government in 1943 as part of the secret wartime effort to produce plutonium for nuclear weapons. The site operated for about four decades and produced roughly two thirds of the 100 metric tons of plutonium in the U.S. inventory. Millions of cubic meters of radioactive and chemically hazardous wastes, the by-product of plutonium production, were stored in tanks and ancillary facilities at the site or disposed or discharged to the subsurface, the atmosphere, or the Columbia River. In the late 1980s, the primary mission of the Hanford Site changed from plutonium production to environmental restoration. The federal government, through the U.S. Department of Energy (DOE), began to invest human and financial resources to stabilize and, where possible, remediate the legacy of environmental contamination created by the defense mission. During the past few years, this financial investment has exceeded $1 billion annually. DOE, which is responsible for cleanup of the entire weapons complex, estimates that the cleanup program at Hanford will last until at least 2046 and will cost U.S. taxpayers on the order of $85 billion. Science and Technology for Environmental Cleanup at Hanford provides background information on the Hanford Site and its Integration Project,discusses the System Assessment Capability, an Integration Project-developed risk assessment tool to estimate quantitative effects of contaminant releases, and reviews the technical elements of the scierovides programmatic-level recommendations.

Public Participation in Environmental Assessment and Decision Making
Public Participation in Environmental Assessment and Decision Making

Author: National Research Council

Publisher: National Academies Press

Published: 2008-11-07

Total Pages: 322

ISBN-13: 0309134412

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Federal agencies have taken steps to include the public in a wide range of environmental decisions. Although some form of public participation is often required by law, agencies usually have broad discretion about the extent of that involvement. Approaches vary widely, from holding public information-gathering meetings to forming advisory groups to actively including citizens in making and implementing decisions. Proponents of public participation argue that those who must live with the outcome of an environmental decision should have some influence on it. Critics maintain that public participation slows decision making and can lower its quality by including people unfamiliar with the science involved. This book concludes that, when done correctly, public participation improves the quality of federal agencies' decisions about the environment. Well-managed public involvement also increases the legitimacy of decisions in the eyes of those affected by them, which makes it more likely that the decisions will be implemented effectively. This book recommends that agencies recognize public participation as valuable to their objectives, not just as a formality required by the law. It details principles and approaches agencies can use to successfully involve the public.

Science and Decisions
Science and Decisions

Author: National Research Council

Publisher: National Academies Press

Published: 2009-03-24

Total Pages: 422

ISBN-13: 0309120462

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Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.