Molecular Biology of the Cell
Author:
Publisher:
Published: 2002
Total Pages: 0
ISBN-13: 9780815332183
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Processing and Presentation of Antigens
Author: Benvenuto Pernis
Publisher: Elsevier
Published: 2012-12-02
Total Pages: 339
ISBN-13: 0323155278
DOWNLOAD EBOOKProcessing and Presentation of Antigens brings together the views of immunologists, biochemists, cell biologists, and virologists who have a common interest in the early phases of the immune response. Antigen processing and presentation comprise a series of events that are much more complex and sophisticated than had been thought for a long time, and constitute an essential part of the biology of the immune response to T-dependent protein antigens. The book is organized into seven parts. Part I discusses the major advances and insights in antigen processing, some results on the interaction of antigen with class II MHC molecules, and the precise mechanism involved in antigen processing. Part II presents papers on endosomes, lysosomes, and recycling. Part III deals with studies on presentation in the context of class I MHC molecules. The chapters in Part IV examine interactions of antigens with class II MHC molecules. Part V contains papers on macrophages and dendritic cells as accessory cells. Part VI examines antigen presentation by B cells. Part VII covers studies on T cells.
Janeway's Immunobiology
Author: Kenneth Murphy
Publisher: Garland Science
Published: 2010-06-22
Total Pages:
ISBN-13: 9780815344575
DOWNLOAD EBOOKThe Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Antigen Processing and Presentation
Author: Robert Edward Humphreys
Publisher:
Published: 1994
Total Pages: 360
ISBN-13:
DOWNLOAD EBOOKOne of the few volumes dedicated to antigen processing, this unique text is not only especially current but also valuable for its description of petentially "hot" areas with its "Future Directions" sections. * Current, important topics covered by this text include: Processing and presentation of foreign and self protein antigens to T lymphocytes Intracellular assembley and transport of MHC proteins Regulation of the assembley and expression of processed antigen-MHC complexes
Natural History of the Major Histocompatibility Complex
Author: Jan Klein
Publisher: Wiley-Interscience
Published: 1986
Total Pages: 820
ISBN-13:
DOWNLOAD EBOOKThis work is a natural history of the major histocompatibility complex written for anyone who is working on the MHC but wants to step back and review the complex in its entirety; for anyone who wants to be introduced to the MHC; or for anyone who is just curious about this much talked-about chromosomal region. By natural history is meant an all encompassing treatment of the MHC, both human and mouse, in its entire range and its details - but presented in a way that anybody can understand without consulting a variety of other sources. Most of the details are summarized in the form of tables whereas the text concentrates on generalizations and discussions. Thus, the book will be of interest to immunologists and geneticists seeking an overview of the subject and to graduate students in these disciplines. It will also be of value to technicians working in HLA-typing laboratories.
Avian Immunology
Author: Bernd Kaspers
Publisher: Academic Press
Published: 2012-12-02
Total Pages: 456
ISBN-13: 0123972728
DOWNLOAD EBOOKThe second edition of Avian Immunology provides an up-to-date overview of the current knowledge of avian immunology. From the ontogeny of the avian immune system to practical application in vaccinology, the book encompasses all aspects of innate and adaptive immunity in chickens. In addition, chapters are devoted to the immunology of other commercially important species such as turkeys and ducks, and to ecoimmunology summarizing the knowledge of immune responses in free-living birds often in relation to reproductive success. The book contains a detailed description of the avian innate immune system, encompassing the mucosal, enteric, respiratory and reproductive systems. The diseases and disorders it covers include immunodepressive diseases and immune evasion, autoimmune diseases, and tumors of the immune system. Practical aspects of vaccination are examined as well. Extensive appendices summarize resources for scientists including cell lines, inbred chicken lines, cytokines, chemokines, and monoclonal antibodies. The world-wide importance of poultry protein for the human diet, as well as the threat of avian influenza pandemics like H5N1 and heavy reliance on vaccination to protect commercial flocks makes this book a vital resource. This book provides crucial information not only for poultry health professionals and avian biologists, but also for comparative and veterinary immunologists, graduate students and veterinary students with an interest in avian immunology. - With contributions from 33 of the foremost international experts in the field, this book provides the most up-to-date review of avian immunology so far - Contains a detailed description of the avian innate immune system reviewing constitutive barriers, chemical and cellular responses; it includes a comprehensive review of avian Toll-like receptors - Contains a wide-ranging review of the "ecoimmunology" of free-living avian species, as applied to studies of population dynamics, and reviews methods and resources available for carrying out such research
Antigen Presenting Cells
Author: Harald Kropshofer
Publisher: John Wiley & Sons
Published: 2006-05-12
Total Pages: 651
ISBN-13: 352760698X
DOWNLOAD EBOOKThis novel, multidisciplinary handbook highlights recent evidence that antigen presenting cells (APCs) are not only key players in the initiation or prevention of an antigen-specific T lymphocyte-mediated adaptive immune response, but also critical regulators and integrators in the interplay between our innate and adaptive immune system. Structured in a clear way to allow access to a very broad readership, the book is written from the viewpoint of a biochemist, immunologist, and scientist with experience in drug development. It covers all cell types involved in antigen presentation, providing the latest immunological facts with a focus on drug development. Backed by a glossary explaining all important technical terms, this short but comprehensive reference covers basic introductory aspects right up to details for advanced specialists.
Molecular Analysis of B Lymphocyte Development and Activation
Author: Harinder Singh
Publisher: Springer Science & Business Media
Published: 2005-02-16
Total Pages: 282
ISBN-13: 9783540230908
DOWNLOAD EBOOKTheBlymphocytelineagerepresentsaleadingsystemforexploring- lecularmechanismsthatunderliecellfatespecification, differentiationand cellular activation. In the past five years major advances have been achievedintheanalysisofearlyBcelldevelopment, AIDdependentclass switchrecombinationaswellassomatichypermutationandBlimp-1re- latedplasmacelldifferentiation. Manyofthesefindingsandtheirimpli- tionsarecoveredinthisvolume. Twoemergentareasofresearchthatare includedinthecontributionsfocusonthepre-BCRandIkaros-familyp- teins. Thepre-BCRisanunusualmoleculardevicethatisusedtoexecute acriticaldevelopmentalcheckpointintheBlineage. Itsmechanismof- tion in relationto the pre-TCR and the mature antigen receptors (BCR, TCR)isofconsiderableinterest. Ikaros-familyproteinsappeartofunction viarecruitingtargetgenestodomainsofcentromericheterochromatinin the nucleus. Initially discovered in lymphocytes, they represent a novel system of gene regulationvia nuclearcompartmentalization. Finally, the volumeincludesachapteronWntsignalinginlymphopoiesis. Analysisof thisevolutionallyconservedpathwaywhichregulatescellularproliferation anddifferentiationindiversedevelopmentalcontextsbenefitedenormo- lyfromthediscoveryoftheLEF/TCFfamilyoffactorsinlymphocyticl- eages. ThisvolumeisdedicatedtothememoryofEugeniaSpanopoulou, ac- leagueandahighlyvaluedmemberofourscientificcommunity. Itc- tainsachapteronthebiochemistryofV(D)JrecombinationthatEugenia co-authoredwithDavidSchatz. Obituary Eugenia Spanopoulou was an extraordinary person and scientist. Her enormousintelligenceandenergysparkedimportantscientificdiscoveries, andvaultedhertoapointofbreathtakingpotential apotentialabruptly erasedattheageof37withthecrashofSwissairflight111onSeptember 3,1998. Lostwithherwereherhusband, AndrewHodtsev, andyoungson, Platon. Eugeniawaspassionatelyinterestedinunderstandingthemolecular- sisofdevelopmentandchoseashermodelsystemthedevelopmentofB andTlymphocytes. Shebeganbystudyingthetranscriptionalregulation oftheTcell-specificgene, Thy-1, asagraduatestudentinFrankGrosveld s labatMillHill, London. Thereafter, sheturnedherattentiontothetopicof V(D)Jrecombination, firstasapostdoctoralfellowwithDavidBaltimore attheWhiteheadInstituteinCambridge, Massachusettsandsubsequently inherownlaboratoryatMountSinaiSchoolofMedicineinNewYorkCity. Eugeniamadefundamentaldiscoveriesconcerningthebiochemicalme- anismofthisreaction, andhowdefectsinitscentralenzymaticcom- nents, RAG1andRAG2, canleadtoahumanseverecombinedimmuno- ficiencydisorder, knownasOmennsyndrome. Atthetimeof herdeath, shehadbeenaHowardHughesMedicalInstituteinvestigatorforlessthan ayear, buthadalreadyassembledalaboratoryof15peopleworkingonan extensivearrayoftopicsinearlylymphocytedevelopmentandV(D)J- combination. Eugenialivedeachmomentofherlifewithanintensityfittingforthe cityinwhichshelived. LikeManhattan, shesleptlittle. Sheexpectedagreat dealofherself, andonlyalittlelessfromthosewithwhomsheworked. - geniaalsohadhighexpectationsforthescientificprocessandwasouts- keninherpraiseorcondemnationofthosewhometorfellshortofthose expectations. Shewasquicktoformanopinionanddevotedherselffe- ciouslytofriendshipsandhypotheses. PerhapsthegreatesttestimonytoEugeniaistheaffectionandreverence feltforherby themembersof herlab. Whilethisstemmedinnosmall partfrompredictablesources herkeenmindandbroadknowledge it founditsdeepestsourceinEugenia sabilitytotransmit, byexampleand word, her love of a life of learning and exploration. SandroSantigata, a graduatestudentinEugenia slab, capturedthiseloquentlyatthememorial serviceforEugeniaandAndrew, whenhesaid: VIII Obituary Ifyouhaveeverbeenspellboundbyagreatstatue, enrapturedbyits strengthandvitality, enthralledbyitspurity, purposeandgraceandupli- edbythesenseofhopethatitsparkswithinyoursoul, thenyouhave- readyunderstoodwhyIadoredEugenia. Shesimplyembodiedtheideal- ticprinciplesthatformthecoreofadedicatedgraduatestudent sheart. Andtoseethesevaluesmaterializedintheformofone smentorcanbe nothingshortofinspirational. ListofContents GeneRegulatoryNetworksOrchestratingBCellFateSpecification, Commitment, andDifferentiation K. L. Medina.H. Singh. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Helix-Loop-HelixProteinsinLymphocyteLineageDetermination B. L. Kee. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 Ikaros-FamilyProteins: InSearchofMolecularFunctions DuringLymphocyteDevelopment B. S. Cobb.S. T. Smale. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 BiochemistryofV(D)JRecombination y D. G. Schatz.E. Spanopoulou. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 Thepre-BcellReceptorinBCellDevelopment: RecentAdvances, PersistentQuestionsandConservedMechanisms M. R. Clark.A. B. Cooper.L. D. Wang.I. Aifantis. . . . . . . . . . . . . . . . . 87 TranscriptionalControlofBCellActivation L. M. Corcoran . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 105 ExpressionofMHCIIGenes G. Drozina.J. Kohoutek.N. Jabrane-Ferrat.B. M. Peterlin. . . . . . . . . 147 ClassSwitchRecombination: AnEmergingMechanism A. L. Kenter. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 171 Blimp-1;ImmunoglobulinSecretion andtheSwitchtoPlasmaCells R. Sciammas.M. M. Davis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 201 WntSignalinginLymphopoiesis A. Timm.R. Grosschedl. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 225 SubjectIndex . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 253 ListofContributors (Theiraddressescanbefoundatthebeginningoftheirrespectivechapters. ) Aifantis, I. 87 Kohoutek, J. 147 Clark, M. R. 87 Medina, K. L. 1 Cobb, B. S. 29 Peterlin, B. M. 147 Cooper, A. B. 87
Antigen Processing and Recognition
Author: James McCluskey
Publisher: CRC Press
Published: 1991-09-03
Total Pages: 282
ISBN-13: 9780849369322
DOWNLOAD EBOOKThis book provides a state-of-the-art review of the processing, presentation, and subsequent recognition of antigens by T cells. Topics discussed include the structure of MHC molecules, the nature and specificity of human class II molecule interactions with peptide antigens, the class II invariant chain, antigen processing and presentation by class I MHC molecules, the biology of antigen processing, and the presentation and role of accessory molecules in T cell recognition. Other chapters feature discussions about the T cell allorecognition of MHC molecules, the recognition of minor antigens, and the concept of "superantigens." Color plates demonstrate the three-dimensional structure of MHC molecules and peptide antigen interaction with MHC molecules. Diagrams illustrate antigen presentation pathways, T cell receptor-MHC interaction and accessory molecule interactions. Antigen Processing and Recognition will be a valuable addition to the libraries of students and teachers of immunology, as well as cell biologists who are looking for a unified view of this rapidly expanding subject.
Proteolytic Signaling in Health and Disease
Author: Andre Zelanis
Publisher: Academic Press
Published: 2021-10-13
Total Pages: 308
ISBN-13: 0323856977
DOWNLOAD EBOOKIn recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and pathologies. Proteolytic Signaling in Health and Disease provides an in-depth discussion of fundamental physiological and developmental processes regulated by proteases, from protein turnover and autophagy to antigen processing and presentation and major histocompatibility complex (MHC) molecules. Moving on from basic biology, international chapter authors examine a range of pathological conditions associated with proteolysis, including inflammation, wound healing, and cancer. Later chapters discuss the newly discovered network of connected events among proteases (and their inhibitors), the so-called 'protease web', and how best to study it. This book also empowers new research with up-to-date analytical methods and step-by-step protocols for studying proteolytic signaling events. - Examines biological events triggered by proteolytic enzyme activity across human development and pathologies - Discusses the role of proteolytic signaling in inflammation, wound healing, and cancer, among other disease types - Features methods and protocols supporting further study of proteolytic signaling events - Includes chapter contributions from international leaders in the field
