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Author: Graham L. Patrick
Publisher: Oxford University Press, USA
Published: 2013-01-10
Total Pages: 814
ISBN-13: 0199697396
DOWNLOAD EBOOKThis volume provides an introduction to medicinal chemistry. It covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug.
Author: Gareth Thomas
Publisher: John Wiley & Sons
Published: 2011-09-20
Total Pages: 660
ISBN-13: 111996542X
DOWNLOAD EBOOKMedicinal Chemistry: An Introduction, Second Edition provides a comprehensive, balanced introduction to this evolving and multidisciplinary area of research. Building on the success of the First Edition, this edition has been completely revised and updated to include the latest developments in the field. Written in an accessible style, Medicinal Chemistry: An Introduction, Second Edition carefully explains fundamental principles, assuming little in the way of prior knowledge. The book focuses on the chemical principles used for drug discovery and design covering physiology and biology where relevant. It opens with a broad overview of the subject with subsequent chapters examining topics in greater depth. From the reviews of the First Edition: "It contains a wealth of information in a compact form" ANGEWANDTE CHEMIE, INTERNATIONAL EDITION "Medicinal Chemistry is certainly a text I would chose to teach from for undergraduates. It fills a unique niche in the market place." PHYSICAL SCIENCES AND EDUCATIONAL REVIEWS
Author: Alex Gringauz
Publisher: Wiley-VCH
Published: 1997
Total Pages: 744
ISBN-13:
DOWNLOAD EBOOKThis work brigdges the compartmentalized undergraduate organic and biochemistry and biology subjects to the pharmacology and the clinical areas a modern pharmacy practice requires. The changes and constantly increasing responsibilities of today's pharmacist have dictated a restructuring of the pharmacy curriculum, including individual course content. This book reflects and addresses these developments. This is a well-written work that covers most major areas of pharmaceutical research. The text is presented in a logical and concise fashion being divided into chapters based upon therapeutic topic. This makes the work very useful for teaching a course in medicinal chemistry since therapeutic areas can be separately covered without having to make use of the entire book which overall contains a tremendous amount of information. This book is a significant contribution to understanding what medicinal chemistry is and how this science is used to develop new therapeutic agents.
Author: Marc Harrold
Publisher: ASHP
Published: 2013-01-18
Total Pages: 405
ISBN-13: 1585283649
DOWNLOAD EBOOKMedicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation. In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group. Key features include: • Discussions on the roles and characteristics of organic functional groups, including the identification of acidic and basic functional groups. • How to solve problems involving pH, pKa, and ionization; salts and solubility; drug binding interactions; stereochemistry; and drug metabolism. • Numerous examples and expanded discussions for complex concepts. • Therapeutic examples that link the importance of medicinal chemistry to pharmacy and healthcare practice. • An overview of structure activity relationships (SARs) and concepts that govern drug design. • Review questions and practice problems at the end of each chapter that allow readers to test their understanding, with the answers provided in an appendix. Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry. About the Authors Marc W. Harrold, BS, Pharm, PhD, is Professor of Medicinal Chemistry at the Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA. Professor Harrold is the 2011 winner of the Omicron Delta Kappa "Teacher of the Year" award at Duquesne University. He is also the two-time winner of the "TOPS" (Teacher of the Pharmacy School) award at the Mylan School of Pharmacy. Robin M. Zavod, PhD, is Associate Professor for Pharmaceutical Sciences at the Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, where she was awarded the 2012 Outstanding Faculty of the Year award. Professor Zavod also serves on the adjunct faculty for Elmhurst College and the Illinois Institute of Technology. She currently serves as Editor-in-Chief of the journal Currents in Pharmacy Teaching and Learning.
Author: Graham L. Patrick
Publisher: Oxford University Press, USA
Published: 2015
Total Pages: 587
ISBN-13: 0198708432
DOWNLOAD EBOOKIntroduction to Drug Synthesis explores the central role played by organic synthesis in the process of drug design and development - from the generation of novel drug structures to the improved efficiency of large scale synthesis.
Author: Graham L. Patrick
Publisher:
Published: 2001
Total Pages: 652
ISBN-13:
DOWNLOAD EBOOKAuthor: Thomas L. Lemke
Publisher:
Published: 1988
Total Pages: 156
ISBN-13:
DOWNLOAD EBOOKAuthor: Graham Patrick
Publisher: Oxford University Press
Published: 2023-02
Total Pages: 956
ISBN-13: 0198866666
DOWNLOAD EBOOKMedication is widely used to support the human body to fight against infection and pain. In an era of pharmaceutical and medicinal challenges, and thanks to the media, we have all become more familiar with drug production and distribution. However, do we really know what happens before thosedrugs are distributed? What's the process behind drug discovery? How do our bodies interact with those chemicals?An Introduction to Medicinal Chemistry, 7th edition, offers a complete and accessible approach to this multidisciplinary field. Its guiding and accessible writing style makes this text an ideal tool for those studying the subject for first time, but also for those looking to deepen their knowledge.The book guides students through a journey from understanding the principles of drug action targets in Part A, to how drugs interact at a molecular level with our organs to offer therapeutic value in Part B, and exploring drug design and discovery, as well as regulatory procedures, in Part C.Offering a practical approach, Part D provides a deeper look at specific tools and techniques of medicinal chemistry, concluding with emerging topics including antibodies and anticancer agents in Part E. From principles to practice, accompanied by examples and case studies emerging from currentbiomedical research, the book will equip students with a robust understanding of medicinal chemistry, which will prepare them for future success.Oxford Learning Link features:For students:DT Newly added Multiple-Choice Questions to support self-directed learningDT Web articles describing recent developments in the field and further information on topics covered in the bookDT Journal Club to encourage students to critically analyse the research literatureDT Molecular Modelling Exercises based on the use of freely available software.DT New assignments to help students develop their data analysis and problem-solving skillsFor registered adopters of the book:DT A test bank of additional multiple-choice questions, with links to relevant sections in the bookDT Answers to end-of-chapter questions.DT Figures from the book, ready to download.DT Power Point slides to accompany every chapter in the book.
Author: Andrew Davis
Publisher: Royal Society of Chemistry
Published: 2015-07-07
Total Pages: 789
ISBN-13: 1782621830
DOWNLOAD EBOOKDrug discovery is a constantly developing and expanding area of research. Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry covers the past, present and future of the entire drug development process. Highlighting the recent successes and failures in drug discovery, the book helps readers to understand the factors governing modern drug discovery from the initial concept through to a marketed medicine. With chapters covering a wide range of topics from drug discovery processes and optimization, development of synthetic routes, pharmaceutical properties and computational biology, the handbook aims to enable medicinal chemists to apply their academic understanding to every aspect of drug discovery. Each chapter includes expert advice to not only provide a rigorous understanding of the principles being discussed, but to provide useful hints and tips gained from within the pharmaceutical industry. This expertise, combined with project case studies, highlighting and discussing all areas of successful projects, make this an essential handbook for all those involved in pharmaceutical development.
Author: Joseph E. Rice
Publisher: Academic Press
Published: 2014-04-14
Total Pages: 219
ISBN-13: 0128008326
DOWNLOAD EBOOKOrganic Chemistry Concepts and Applications for Medicinal Chemistry provides a valuable refresher for understanding the relationship between chemical bonding and those molecular properties that help to determine medicinal activity. This book explores the basic aspects of structural organic chemistry without going into the various classes of reactions. Two medicinal chemistry concepts are also introduced: partition coefficients and the nomenclature of cyclic and polycyclic ring systems that comprise a large number of drug molecules. Given the systematic name of a drug, the reader is guided through the process of drawing an accurate chemical structure. By emphasizing the relationship between structure and properties, this book gives readers the connections to more fully comprehend, retain, apply, and build upon their organic chemistry background in further chemistry study, practice, and exams. - Focused approach to review those organic chemistry concepts that are most important for medicinal chemistry practice and understanding - Accessible content to refresh the reader's knowledge of bonding, structure, functional groups, stereochemistry, and more - Appropriate level of coverage for students in organic chemistry, medicinal chemistry, and related areas; individuals seeking content review for graduate and medical courses and exams; pharmaceutical patent attorneys; and chemists and scientists requiring a review of pertinent material
