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Author: Bernhard Palsson
Publisher: Cambridge University Press
Published: 2015-01-26
Total Pages: 551
ISBN-13: 1107038855
DOWNLOAD EBOOKThe first comprehensive single-authored textbook on genome-scale models and the bottom-up approach to systems biology.
Author: Alberto Fuente
Publisher: Springer Science & Business Media
Published: 2014-01-03
Total Pages: 135
ISBN-13: 3642451616
DOWNLOAD EBOOKThis book presents recent methods for Systems Genetics (SG) data analysis, applying them to a suite of simulated SG benchmark datasets. Each of the chapter authors received the same datasets to evaluate the performance of their method to better understand which algorithms are most useful for obtaining reliable models from SG datasets. The knowledge gained from this benchmarking study will ultimately allow these algorithms to be used with confidence for SG studies e.g. of complex human diseases or food crop improvement. The book is primarily intended for researchers with a background in the life sciences, not for computer scientists or statisticians.
Author: Florian Markowetz
Publisher: Cambridge University Press
Published: 2015-07-02
Total Pages: 287
ISBN-13: 131638098X
DOWNLOAD EBOOKWhereas genetic studies have traditionally focused on explaining heritance of single traits and their phenotypes, recent technological advances have made it possible to comprehensively dissect the genetic architecture of complex traits and quantify how genes interact to shape phenotypes. This exciting new area has been termed systems genetics and is born out of a synthesis of multiple fields, integrating a range of approaches and exploiting our increased ability to obtain quantitative and detailed measurements on a broad spectrum of phenotypes. Gathering the contributions of leading scientists, both computational and experimental, this book shows how experimental perturbations can help us to understand the link between genotype and phenotype. A snapshot of current research activity and state-of-the-art approaches to systems genetics are provided, including work from model organisms such as Saccharomyces cerevisiae and Drosophila melanogaster, as well as from human studies.
Author: Institute of Medicine
Publisher: National Academies Press
Published: 2011-12-30
Total Pages: 570
ISBN-13: 0309219396
DOWNLOAD EBOOKMany potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.
Author: Karthik Raman
Publisher: CRC Press
Published: 2021-05-30
Total Pages: 359
ISBN-13: 0429944527
DOWNLOAD EBOOKThis book delivers a comprehensive and insightful account of applying mathematical modelling approaches to very large biological systems and networks—a fundamental aspect of computational systems biology. The book covers key modelling paradigms in detail, while at the same time retaining a simplicity that will appeal to those from less quantitative fields. Key Features: A hands-on approach to modelling Covers a broad spectrum of modelling, from static networks to dynamic models and constraint-based models Thoughtful exercises to test and enable understanding of concepts State-of-the-art chapters on exciting new developments, like community modelling and biological circuit design Emphasis on coding and software tools for systems biology Companion website featuring lecture videos, figure slides, codes, supplementary exercises, further reading, and appendices: https://ramanlab.github.io/SysBioBook/ An Introduction to Computational Systems Biology: Systems-Level Modelling of Cellular Networks is highly multi-disciplinary and will appeal to biologists, engineers, computer scientists, mathematicians and others.
Author: Ilya Shmulevich
Publisher: SIAM
Published: 2010-01-21
Total Pages: 276
ISBN-13: 0898716926
DOWNLOAD EBOOKThe first comprehensive treatment of probabilistic Boolean networks, unifying different strands of current research and addressing emerging issues.
Author: Wray Buntine
Publisher: Springer Science & Business Media
Published: 2009-09-03
Total Pages: 787
ISBN-13: 3642041736
DOWNLOAD EBOOKThis book constitutes the refereed proceedings of the joint conference on Machine Learning and Knowledge Discovery in Databases: ECML PKDD 2009, held in Bled, Slovenia, in September 2009. The 106 papers presented in two volumes, together with 5 invited talks, were carefully reviewed and selected from 422 paper submissions. In addition to the regular papers the volume contains 14 abstracts of papers appearing in full version in the Machine Learning Journal and the Knowledge Discovery and Databases Journal of Springer. The conference intends to provide an international forum for the discussion of the latest high quality research results in all areas related to machine learning and knowledge discovery in databases. The topics addressed are application of machine learning and data mining methods to real-world problems, particularly exploratory research that describes novel learning and mining tasks and applications requiring non-standard techniques.
Author: Michelangelo Ceci
Publisher: Springer
Published: 2017-12-29
Total Pages: 881
ISBN-13: 3319712462
DOWNLOAD EBOOKThe three volume proceedings LNAI 10534 – 10536 constitutes the refereed proceedings of the European Conference on Machine Learning and Knowledge Discovery in Databases, ECML PKDD 2017, held in Skopje, Macedonia, in September 2017. The total of 101 regular papers presented in part I and part II was carefully reviewed and selected from 364 submissions; there are 47 papers in the applied data science, nectar and demo track. The contributions were organized in topical sections named as follows: Part I: anomaly detection; computer vision; ensembles and meta learning; feature selection and extraction; kernel methods; learning and optimization, matrix and tensor factorization; networks and graphs; neural networks and deep learning. Part II: pattern and sequence mining; privacy and security; probabilistic models and methods; recommendation; regression; reinforcement learning; subgroup discovery; time series and streams; transfer and multi-task learning; unsupervised and semisupervised learning. Part III: applied data science track; nectar track; and demo track.
Author: Edgar Wingender
Publisher: Wiley-Blackwell
Published: 1993
Total Pages: 452
ISBN-13:
DOWNLOAD EBOOKA much-needed guide through the overwhelming amount of literature in the field. Comprehensive and detailed, this book combines background information with the most recentinsights. It introduces current concepts, emphasizing the transcriptional control of genetic information. Moreover, it links data on the structure of regulatory proteins with basic cellular processes. Both advanced students and experts will find answers to such intriguing questions as: - How are programs of specific gene repertoires activated and controlled? - Which genes drive and control morphogenesis? - Which genes govern tissue-specific tasks? - How do hormones control gene expression in coordinating the activities of different tissues? An abundant number of clearly presented glossary terms facilitates understanding of the biological background. Speacial feature: over 2200 (!) literature references.
Author: Markus Juhana Herrgard
Publisher:
Published: 2004
Total Pages: 736
ISBN-13:
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