Alzheimer's Disease and Infectious Causes
Alzheimer's Disease and Infectious Causes

Author: Elaine A. Moore

Publisher: McFarland

Published: 2020-04-02

Total Pages: 233

ISBN-13: 1476678618

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With the recent discovery that amyloid beta protein, the cause of plaques in Alzheimer's disease, is an antimicrobial peptide produced in response to infection, many researchers are focusing on the role infection plays in the development of Alzheimer's disease. Brain studies have also identified a number of different viruses, bacteria, fungi, and protozoa in the postmortem brain specimens of Alzheimer's patients. Infection (particularly chronic, latent and persistent infections) causes an immune response that leads to inflammation and brain cell degeneration, which are characteristic features of Alzheimer's disease. Sources of infection in Alzheimer's disease vary from childhood infections to gut microbes that find their way into the brain as a result of aging, leaky gut syndrome, and increased permeability of the blood brain barrier. Studies and ongoing clinical trials show that treatment of viral and bacterial infections, as well as restoring a healthy balance to the gut microbiome, can reduce disease risk and improve symptoms in patients with Alzheimer's disease. This book serves as an introduction to the human microbiome and the role that infection plays in the development of Alzheimer's disease.

Alzheimer's Disease and Infectious Causes
Alzheimer's Disease and Infectious Causes

Author: Elaine A. Moore

Publisher: McFarland

Published: 2020-04-01

Total Pages: 233

ISBN-13: 1476638918

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With the recent discovery that amyloid beta protein, the cause of plaques in Alzheimer's disease, is an antimicrobial peptide produced in response to infection, many researchers are focusing on the role infection plays in the development of Alzheimer's disease. Brain studies have also identified a number of different viruses, bacteria, fungi, and protozoa in the postmortem brain specimens of Alzheimer's patients. Infection (particularly chronic, latent and persistent infections) causes an immune response that leads to inflammation and brain cell degeneration, which are characteristic features of Alzheimer's disease. Sources of infection in Alzheimer's disease vary from childhood infections to gut microbes that find their way into the brain as a result of aging, leaky gut syndrome, and increased permeability of the blood brain barrier. Studies and ongoing clinical trials show that treatment of viral and bacterial infections, as well as restoring a healthy balance to the gut microbiome, can reduce disease risk and improve symptoms in patients with Alzheimer's disease. This book serves as an introduction to the human microbiome and the role that infection plays in the development of Alzheimer's disease.

Handbook of Infection and Alzheimer's Disease
Handbook of Infection and Alzheimer's Disease

Author: J. Miklossy

Publisher: IOS Press

Published: 2017-03-10

Total Pages: 420

ISBN-13: 1614997063

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Alzheimer’s disease is one of the biggest emerging public health problems in the world. Although the last four decades have yielded important insights into the pathogenesis of Alzheimer’s disease, its cause is still unclear, and if it is not discovered the world will face an unprecedented healthcare problem by the middle of this century. In recent years, evidence of the microbial origin of various chronic inflammatory disorders – including several neurodegenerative, neuropsychiatric and other systemic disorders – has been steadily growing. Accumulating new and historic observations are providing evidence of an association between Alzheimer’s disease and certain infectious agents, and may offer new opportunities for ground-breaking healthcare solutions. This handbook assembles and connects findings with regard to the infectious origin of Alzheimer’s disease, and the data presented in its chapters deserves the attention of the neuroscience community, physicians and the health departments of governments worldwide by virtue of its amount and quality. This handbook offers a comprehensive overview of the current knowledge regarding the topic of infection and Alzheimer’s disease, which could pinpoint the cause of this disease. Influential diagnosis, treatment and prevention strategies may also emerge from this crucial research area.

Neurology in Clinical Practice
Neurology in Clinical Practice

Author: Walter George Bradley

Publisher:

Published: 2004

Total Pages: 1672

ISBN-13: 9780750674690

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New edition, completely rewritten, with new chapters on endovascular surgery and mitochrondrial and ion channel disorders.

Explicating the relationship between Infections and Alzheimer’s Disease (AD) Etiology, especially Late-onset AD (LOAD).
Explicating the relationship between Infections and Alzheimer’s Disease (AD) Etiology, especially Late-onset AD (LOAD).

Author: Dr.H.K.Saboowala.

Publisher: Dr.Hakim Saboowala

Published: 2020-09-23

Total Pages: 66

ISBN-13:

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Explicating the relationship between Infections and Alzheimer’s Disease (AD) Etiology, especially Late-onset AD (LOAD). Inflammation is a part of the first line of defense of the body against invasive pathogens and plays a crucial role in tissue regeneration and repair. A proper inflammatory response ensures the suitable resolution of inflammation and elimination of harmful stimuli, but when the inflammatory reactions are inappropriate it can lead to damage of the surrounding normal cells. The relationship between infections and Alzheimer’s Disease (AD) etiology, especially late-onset AD (LOAD) has been continuously debated over the past three decades. Among bacteria special attention is focused on spirochetes family and on periodontal pathogens such as Porphyromonas gingivalis or Treponema denticola that could cause chronic periodontitis and possibly contribute to the clinical onset of AD. Emerging evidence supports the hypothesis of the role of neurotropic viruses from the Herpesviridae family, especially Human herpesvirus 1 (HHV-1), Cytomegalovirus (CMV), and Human herpesvirus 2 (HHV-2), in AD neuropathology. Recent investigations also indicate the association between Hepatitis C virus (HCV) infection and dementia. An attempt has been made to discuss whether infections could be a causative factor that promotes the progression of AD along with Preventive and therapeutic approaches to AD in the context of an infectious etiology of the disease and summarize recent investigations associating infectious agents and chronic inflammation with AD. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)

Viruses: Essential Agents of Life
Viruses: Essential Agents of Life

Author: Günther Witzany

Publisher: Springer Science & Business Media

Published: 2012-11-13

Total Pages: 432

ISBN-13: 940074899X

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A renaissance of virus research is taking centre stage in biology. Empirical data from the last decade indicate the important roles of viruses, both in the evolution of all life and as symbionts of host organisms. There is increasing evidence that all cellular life is colonized by exogenous and/or endogenous viruses in a non-lytic but persistent lifestyle. Viruses and viral parts form the most numerous genetic matter on this planet.

The Origin of Disease
The Origin of Disease

Author: Carolyn Merchant JD

Publisher: AuthorHouse

Published: 2018-10-12

Total Pages: 623

ISBN-13: 1546259791

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US REVIEW OF BOOKS, Michael Radon theusreview.com/reviews/The-Origin-of-Disease-by-Carolyn-Merchant-JD-and-Christopher-Merchant-MD.html#.XLBmAehKi5o Containing exciting information and thought, this book could help people find ways to improve or avoid diseases that can dramatically alter lives. This book challenges a lot of accepted thinking in Western medicine, but all truly impactful ideas have to shatter the old to move [thought] forward. [T]he authors identify a pattern of the root causes of chronic illnesses and what can be done to fight maladies that many medical professionals say just happen and have to be lived with. For many people, medical books can be a hard hurdle to jump, but this book is written in an accessible style and format, and contains information useful to the layperson, not just medical professionals. PACIFIC BOOK REVIEW. Anthony Avina pacificbookreview.com/the-origin-of-disease-the-war-within This book does a great job of creating a conversation. It is a detailed, knowledgeable and thorough book filled with fascinating theories that all readers should have the opportunity to explore themselves. This is definitely an interesting book that will fascinate patients suffering from illnesses as well as doctors seeking new answers or medical researchers alike. It is a new perspective that is interesting to see, as the authors relay the causes of various chronic illnesses. The authors command over the medical expertise is both technical and yet relayed easily enough for patients and doctors alike to understand. If you enjoy medical books, suffer from an ailment or are curious about health overall, then you’ll want to grab your copy of The Origin of Disease: The War Within, Today! www.facebook.com/carolyn.merchant/39 www.theoriginofdiseases.com

Apolipoprotein E and Alzheimer’s Disease
Apolipoprotein E and Alzheimer’s Disease

Author: A.D. Roses

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 208

ISBN-13: 3642801099

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There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.

The Convergence of Infectious Diseases and Noncommunicable Diseases
The Convergence of Infectious Diseases and Noncommunicable Diseases

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2020-01-02

Total Pages: 185

ISBN-13: 0309496144

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On June 11 and June 12, 2019, the National Academies convened a workshop to explore the growing understanding of how the interplay between humans and microbes affects host physiology and causes noncommunicable diseases. Discussions included an overview of colliding epidemics, emerging research on associations between infectious and noncommunicable diseases, risks posed by chronic diseases to the development and severity of infectious diseases, and the influence of the microbiome. Workshop participants also examined the challenges and opportunities of convergence, the integration of health care delivery models and interventions, potential approaches for research, policy, and practice in the immediate-term, and potential directions for the long-term. This publication summarizes the presentations and discussions from the workshop.