This book presents a comprehensive overview of medical and pharmaceutical applications of human serum albumin (HSA), with updates on structural aspects of albumin from the perspectives of X-ray crystallography and NMR, endogenous and exogenous ligand binding of albumin in various pathological conditions, and genetic variants and their phenotypes. Rapid progress and development of its applications have resulted in outstanding results for which albumin has clearly been proven to be a robust biomaterial. Contributions from leading international experts in this field show how HSA is applied to diagnosis, therapy, drugs, and treatment, with a comprehensive introduction of HSA. This volume will appeal to scientists in pharmaceutical and medical research including pharmaceutical chemists, pharmacokineticists, toxicologists, and biochemists not only in academia but also in industry. Readers can effectively acquire the most recent knowledge of applications of HSA and its impact on human health in a single volume.
The first of its kind, All About Albumin summarizes the chemistry, genetics, metabolism, clinical implications, and commercial aspects of albumin. It provides the most up-to-date sequences, structures, and compositions of many species, and includes more than 2000 references. - Includes up-to-date sequences, structures, and compositions of many species - Reviews the protein chemistry, genetic control, and metabolism of albumin - Covers medical and cell culture applications in vivo and in vitro, with a section on handling albumin in the laboratory - Presents the relationship of albumin to its superfamily with an updated scheme for their evolution - First complete coverage of all aspects of serum albumin in one volume, with more than 2000 references
Albumin Structure, Function and Uses reviews the many facets of serum albumin, including its history and evolutionary development, structure and function, synthesis, degradation, distribution and transport, and metabolic behavior. The use, misuse, and abuse of albumin in the treatment of disease are also discussed. This book is comprised of 17 chapters and begins with a commentary on how albumin is used, misused, and abused in the treatment of disease such as peptic ulcer, and a description of the real indications for its use. Concepts in albumin purification are then examined, along with the amino acid sequence of serum albumin and some aspects of its structure and conformational properties. Subsequent chapters explore the phylogenetics of albumin; albumin binding sites; clinical implications of drug-albumin interaction; genetics of human serum albumin; and hepatic synthesis of export proteins. Albumin catabolism and intracellular transport are also considered, together with surgical and clinical aspects of albumin metabolism. This monograph should be a useful resource for biochemists and clinicians.
This edited book comprises of eight chapters dealing on various aspects of pharmaceutical technology for delivery of natural products. Book chapters deal with the solubility and bioavailability enhancement technologies for natural products. Emphasis has also been given on the significance of delivery strategies for improving the therapeutic efficacy of paclitaxel, galantamine and tea constituents.
It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.
Over the past decade, there have been a large number of important studies related to fluid management for the surgical patient, resulting in confusion on this critical aspect of patient care. Proper fluid therapy in the perioperative setting has always been important but has only recently had concrete outcome-based guidelines. This is the first comprehensive, up-to-date and practical summary book on the topic.
Monitoring and Intervention for the Critically Ill Small Animal: The Rule of 20 offers guidance for assessing the patient, interpreting diagnostic test results, and selecting appropriate monitoring procedures. Based on Rebecca Kirby’s time-tested Rule of 20, with a chapter devoted to each item on the checklist Provides comprehensive guidance for monitoring a critically ill small animal patient Emphasizes the interplay of each parameter with one another Designed for fast access on the clinic floor, with potentially life-saving ideas, tips, lists and procedures Presents tables, schematics, algorithms, and drawings for quick reference
#1 DRUG BOOK for Nursing Students! "This is the perfect drug book for nursing school! All the information on the meds is in-depth and all that you need to know."-Abby W. SAFETY FIRST! Davis's Drug Guide for Nurses(R), Seventeenth Edition delivers all the information you need to administer medications safely across the lifespan-well-organized monographs for hundreds of generic and thousands of trade-name drugs. FREE DIGITAL ACCESS Redeem the access code to unlock your one-year, free subscription to DrugGuide.com, Davis's Drug Guide Online, powered by Unbound Medicine. You'll have access to more than 1,700 monographs from your desktop, laptop, or any mobile device with a web browser. Search the complete 5,000-drug database and appendices quickly and efficiently. Build your knowledge with extensively cross-referenced drugs. Keep up to date with FDA drug news. LIFE-SAVING GUIDANCE ... AT A GLANCE New! The AGS Beers Criteria for Potentially Inappropriate Medication Use in Older Adults #1 Drug Guide for patient safety Red tab for high alert medications, plus in-depth high alert and patient safety coverage Red, capitalized letters for life-threatening side effects REMS (Risk Evaluation and Mitigation Strategies) icon Drug-drug, drug-food, drug-natural product interactions Special considerations for patient populations. Geri heading identifies special concerns for older adults. OB and Lact headings highlight information for pregnant and breastfeeding patients. Pedi heading identifies concerns for children. Rep heading identifies considerations for patients of reproductive age. IV Administration subheads Pharmacogenomic content Canadian-specific content In-depth guidance for patient and family teaching FREE LEARNING, CARE PLANNING, AND PATIENT EDUCATION TOOLS Online at FADavis.com Audio Library of 1,200+ drug names help you pronounce important terms Two tutorials, each with a self-test Preventing Medication Errors Psychotropic Drugs Easy-to-Use Calculators Body mass index (BMI) Metric conversions IV drip rates Dosage/KG Fahrenheit/Celsius Interactive Case Studies - brief, real-life scenarios that are followed by a series of questions Audio podcasts delivering information on... Risk Evaluation Mitigation Systems (REMS) How to use Davis's Drug Guide for Nurses(R) Detecting and managing ADRs Evidence-based practice and Pharmacotherapeutics Pharmacogenomics Medication errors Special dosing considerations Educating patients about Safe Medication Use Video clips illustrating the safe administration of medications ONLINE REVIEWS OF THE 16TH EDITION OF DAVIS'S DRUG GUIDE FOR NURSES Five Stars. "I LOVE that this includes nursing interventions, patient teaching and an online access code. Highly recommend."-E.G. Accurate and up to date. "Top notch for nursing students! Includes many things other drug guides l
Human Serum Albumin (HSA) is the most abundant plasma protein. It has been widely used for drug delivery systems and has recently emerged as a versatile carrier for therapeutic agents against diabetes, cancer and infectious diseases. This book provides an overview of the expanding field of preclinical and clinical applications and developments that use albumin as a carrier of drug delivery systems. The authors' discuss the properties of drug binding sites within the structure of HSA, discuss new possibilities for the therapeutic potential of HSA and analyze recently reported HSA-drug complexes including HSA-antibody conjugates. Novel investigations on the applications of albumin fusion proteins are discussed as well, with a focus on tumor targeting and intracellular delivery. Other chapters examine the different aspects of albumin glycation and oxidation, the changes in the structure of human serum albumin determined from infrared spectroscopy and a review of CAPIDAN, a special fluorescent dye, which attaches to drug binding sites of human serum albumin.
This book is not another attempt to create a "cook book" on volume replacement of fluid substitution. This book, in contrast, summarizes the up-to-date-knowledge of this topic presented by experts from a wide range of disciplines. Everybody caring for the critically ill will profit from the different chapters at different levels - nurses, students, residents, consultants, and even experts on volume therapy.
