The book provides a comprehensive and up-to-date account of the information available on the morphological, physiological and evolutionary aspects of specialized cells distributed within the epithelia of the airways in the vertebrates. A lot of work has been done on the cell and molecular biology of these cells which are regarded as as oxygen recep
The book provides a comprehensive and up-to-date account of the information available on the morphological, physiological and evolutionary aspects of specialized cells distributed within the epithelia of the airways in the vertebrates. A lot of work has been done on the cell and molecular biology of these cells which are regarded as as oxygen recep
Arterial chemoreceptors are unique structures which continuously monitor changes in arterial blood oxygen, carbon dioxide, glucose, and acid. Alterations in these gases are almost instantaneously sensed by arterial chemoreceptors and relayed into a physiological response which restores blood homeostasis. Arterial Chemoreception contains updated material regarding the physiology of the primary arterial chemoreceptor; the carotid body. Moreover, this book also explores tantalizing evidence regarding the contribution of the aortic bodies, chromaffin cells, lung neuroepithelial bodies, and brainstem areas involved in monitoring changes in blood gases. Furthermore this collection includes data showing the critical importance of these chemoreceptors in the pathophysiology of human disease and possible therapeutic treatments. This book is a required text for any researcher in the field of arterial chemoreception for years to come. It is also a critical text for physicians searching for bench-to-bedside treatments for heart failure, sleep apnea, and pulmonary hypertension.
List of Participants 1 Hypoxia-Induced Intermitochondrial Junctions in the Rabbit Carotid-Body : An Ultrastructural and Experimental Study. A. VERNA. N. TALIB and A. BARETS. 11 Ultrastructural Studies of the Cat Carotid Body Perfused for Short Periods with Physiological Saline Solutions. R.G. O'REGAN. M. KENNEDY. D. COTTELL and S. FEELY. Morphological and Biochemical 19 Characteristics of the Laryngeal Nerve paraganglia. A. DAHLQVIST. S. HELLSTROM. B. CARLSOO. J.M. PEGUIGNOT and S. DOMEIJ. 29 Central Terminations of Carotid Body Chemoreceptor Afferents. D. JORDAN. S. DONOGHUE. R.B. FELDER and K.M. SPYER. 39 Vascular Geometry of Arterial Chemoreceptors: Learning about the Caritud Body by Studying paraganglia of the Superior Laryngeal Nerve D. M. McDONALD and AMY HASKELL. Altered Function of Cat Carotid Body 50 Chemoreceptors in Prolonged Hyperoxia. S. LAHIRI. E. MULLIGAN. A. MORASHI. S. ADNRONIKOU and M. SHIRAHATA. 59 Glycolysis as a Link for Chemoreception? MARCO A. DELPIANO. Spectrophotometric Studies on Carotid 69 Body Tissue. H. ACKER. C. EYZAGUIRRE. ATP Content in the Cat Carotid Body 78 under Different Experimental Conditions. Support for the Metabolic Hypothesis. A. onESO. L. AL~ffiRAZ and C. GONZALEZ. 91 pathways for Calcium Entry into Type I Cells: Significance for the Secretory Response. A. OBESO. S. FIDONE and C. GONZALEZ. Effects of Cyanide and Acetylcholine on 99 Extracellular K+ and Ca++ Activities in the Cat Carotid Body. R.G. O'REGAN and H. ACKER. Application of the Chemiluminescent 108 Method to Carotid Body for Detecting Choline and Acetylcholine. ARCADI GUAL and JORDI HARSAL.
This volume contains reviews and brief research articles from participants attending the International Society for Arterial Chemoreception meeting, to be held in the USA (July 2017). Each article contains original data and represents up-to-date information concerning the carotid body and oxygen sensing in health and disease. This volume is a required text for all researchers in the field of arterial chemoreception and will provide a valuable reference source for years to come.
This volume reviews basic knowledge of the sensory receptors and reflexes that control respiration and describes recent developments and new directions in research. Thirty-eight distinguished contributors discuss the vascular and comparative aspects of peripheral chemoreceptors; sensory mechanisms of the carotid body; oxygen sensing mechanisms; peripheral chemoreceptor adaptations; central effects of hypoxia; airway mechanisms; and central mechanisms and effectors. The volume is published in the memory of Julius H. Comroe, who influenced and shaped medical education and research in the vital areas that are the focus of this volume.
Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.
Hopefully, this book will be taken off of the shelf frequently to be studied carefully over many years. More than 40 researchers were involved in this project, which examines respiration, circulation, and metabolism from ?sh to the land vertebrates, including human beings. A breathable and stable atmosphere ?rst appeared about 500 million years ago. Oxygen levels are not stable in aquatic environments and exclusively water-breathing ?sh must still cope with the ever-changing levels of O 2 and with large temperature changes. This is re?ected in their sophisticated count- current systems, with high O extraction and internal and external O receptors. 2 2 The conquest for the terrestrial environment took place in the late Devonian period (355–359 million years ago), and recent discoveries portray the gradual transitional evolution of land vertebrates. The oxygen-rich and relatively stable atmospheric conditionsimpliedthatoxygen-sensingmechanismswererelativelysimpleandl- gain compared with acid–base regulation. Recently, physiology has expanded into related ?elds such as biochemistry, molecular biology, morphology and anatomy. In the light of the work in these ?elds, the introduction of DNA-based cladograms, which can be used to evaluate the likelihood of land vertebrates and lung?sh as a sister group, could explain why their cardio-respiratory control systems are similar. The diffusing capacity of a duck lung is 40 times higher than that of a toad or lung?sh. Certainly, some animals have evolved to rich high-performance levels.
Within the world of medicine, the work the pathologist does is integral to positive patient outcomes, but it is rare for the pathologist to actually have any interaction with their patients. Thus, their work can often go unrecognized and uncelebrated. The Unsung Heroes of Paediatric Medicine paints a broad portrait of the myriad facets that go into the making of a superb department of paediatric pathology. Not only is it the science, but it is also the people that helped to make a department such as this grow and flourish, becoming one of the best, if not the best, in North America. Within these pages, Dr. Cutz walks the reader through a century of pediatric pathology at Sick Kids Hospital in Toronto, Ontario. Building on both personal experience and archival material, Dr. Cutz’s memoir touches on the history of pathology and the evolution of pediatric pathology, then moves into a detailed overview of both the leadership and staff of the Department of Pathology at Sick Kids Hospital. In addition, readers can follow Dr. Cutz’s personal journey from his research fellowship to his beginnings as a staff pathologist, ending with his research advances and breakthroughs all made whilst a pathologist at Sick kids. Unsung Heroes also touches on controversies, tragedies, and challenging events from the hospital's history, including digoxin, the Olivieri affair, the rise and fall of Charles Smith, and the Mother Risk controversy, among others.
