Epigenetics of Aging
Epigenetics of Aging

Author: Trygve O. Tollefsbol

Publisher: Springer Science & Business Media

Published: 2009-11-11

Total Pages: 462

ISBN-13: 1441906398

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Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

Time Warped
Time Warped

Author: Claudia Hammond

Publisher: House of Anansi

Published: 2012-08-15

Total Pages: 257

ISBN-13: 1770892133

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We are obsessed with time. However hard we might try, it is almost impossible to spend even one day without the marker of a clock. But how much do we understand about time, and is it possible to retrain our brains and improve our relationship with it? Drawing on the latest research from the fields of psychology, neuroscience, and biology, and using original research on the way memory shapes our understanding of time, acclaimed writer and broadcaster Claudia Hammond delves into the mysteries of time perception. Along the way, she introduces us to an extraordinary array of colourful characters willing to go to great lengths in the interests of research, such as the French speleologist Michel, who spends two months in an ice cave in complete darkness. Time Warped shows us how to manage our time more efficiently, speed time up and slow it down at will, plan for the future with more accuracy, and, ultimately, use the warping of time to our own advantage.

Aging and the Art of Living
Aging and the Art of Living

Author: Jan Baars

Publisher: JHU Press

Published: 2012-10-01

Total Pages: 299

ISBN-13: 1421407094

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Baars explores philosophers from Plato to Foucault as they consider the meaning of aging—and wisdom—in our society. In this deeply considered meditation on aging in Western culture, Jan Baars argues that, in today’s world, living longer does not necessarily mean living better. He contends that there has been an overall loss of respect for aging, to the point that understanding and “dealing with” aging people has become a process focused on the decline of potential and the advance of disease rather than on the accumulation of wisdom and the creation of new skills. To make his case, Baars compares and contrasts the works of such modern-era thinkers as Foucault, Heidegger, and Husserl with the thought of Plato, Aristotle, Sophocles, Cicero, and other Ancient and Stoic philosophers. He shows how people in the classical period—less able to control health hazards—had a far better sense of the provisional nature of living, which led to a philosophical and religious emphasis on cultivating the art of living and the idea of wisdom. This is not to say that modern society’s assessments of aging are insignificant, but they do need to balance an emphasis on the measuring of age with the concept of "living in time." Gerontologists, philosophers, and students will find Baars' discussion to be a powerful, perceptive conversation starter.

The Evening of Life
The Evening of Life

Author: Joseph E. Davis

Publisher: University of Notre Dame Pess

Published: 2020-09-30

Total Pages: 252

ISBN-13: 026810803X

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Although philosophy, religion, and civic cultures used to help people prepare for aging and dying well, this is no longer the case. Today, aging is frequently seen as a problem to be solved and death as a harsh reality to be masked. In part, our cultural confusion is rooted in an inadequate conception of the human person, which is based on a notion of absolute individual autonomy that cannot but fail in the face of the dependency that comes with aging and decline at the end of life. To help correct the ethical impoverishment at the root of our contemporary social confusion, The Evening of Life provides an interdisciplinary examination of the challenges of aging and dying well. It calls for a re-envisioning of cultural concepts, practices, and virtues that embraces decline, dependency, and finitude rather than stigmatizes them. Bringing together the work of sociologists, anthropologists, philosophers, theologians, and medical practitioners, this collection of essays develops an interrelated set of conceptual tools to discuss the current challenges posed to aging and dying well, such as flourishing, temporality, narrative, and friendship. Above all, it proposes a positive understanding of thriving in old age that is rooted in our shared vulnerability as human beings. It also suggests how some of these tools and concepts can be deployed to create a medical system that better responds to our contemporary needs. The Evening of Life will interest bioethicists, medical practitioners, clinicians, and others involved in the care of the aging and dying. Contributors: Joseph E. Davis, Sharon R. Kaufman, Paul Scherz, Wilfred M. McClay, Kevin Aho, Charles Guignon, Bryan S. Turner, Janelle S. Taylor, Sarah L. Szanton, Janiece Taylor, and Justin Mutter

The End of Old Age
The End of Old Age

Author: Marc E. Argonin

Publisher: Da Capo Lifelong Books

Published: 2018-01-16

Total Pages: 214

ISBN-13: 0738219991

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The acclaimed author of How We Age, whose "descriptive powers are a gift to readers" (Sherwin Nuland), presents a hopeful and practical model of aging -- a guide to understanding how we can all make the journey better. As one of America's leading geriatric psychiatrists, Dr. Marc Agronin sees both the sickest and the healthiest of seniors. He observes what works to make their lives better and more purposeful and what doesn't. Many authors can talk about aging from their particular vantage points, but Dr. Agronin is on the front lines as he counsels and treats elderly individuals and their loved ones on a daily basis. The latest scientific research and Dr. Agronin's first-hand experience are brilliantly distilled in The End of Old Age -- a call to no longer see aging as an implacable enemy and to start seeing it as a developmental force for enhancing well-being, meaning, and longevity. Throughout The End of Old Age, the focus is squarely on "So what does this mean for me and my family?" In the final part of the book, Dr. Agronin provides simple but revealing charts that you can fill out to identify, develop, and optimize your unique age-given strengths. It's nothing short of an action plan to help you age better by improving how you value the aging process, guide yourself through stress, and find ways to creatively address change for the best possible experience and outcome.

Ripening Time
Ripening Time

Author: Sherry Ruth Anderson

Publisher: John Hunt Publishing

Published: 2013-10-25

Total Pages: 188

ISBN-13: 1780999623

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In Ripening Time: Inside Stories for Aging with Grace, Sherry Ruth Anderson presents a new perspective on aging. In her latest book, the bestselling author of The Feminine Face of God and The Cultural Creatives invites the reader to engage the aging process through the art of inner inquiry. She guides us beyond our culture's mind traps through stories where elders face into the lies, the losses and endings, the tender and bittersweet and ferocious truths of growing old. Giving us an indispensable compass, she shows how growing into old age can be a fruition, the genuine grace and gift of human ripening. ,

Aging and Time
Aging and Time

Author: Henk Visser

Publisher: Routledge

Published: 2020-11-25

Total Pages: 321

ISBN-13: 1351845942

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The aim of this volume is to revitalise the debate about the concepts of time implicit in the study of aging. The many problems related to aging and the aged put an enormous pressure on the gerontological community to come up with practical applications and solutions. In considering research findings, we must keep in mind the basic assumptions that shape and influence even the most obvious statements about aging. In this multidisciplinary volume, the contributors take on the important task of exploring real issues concerning temporal concepts and approaches to aging; and the concepts of time that are used in thinking about aging determine to a large extent the way aging is approached. Most studies of aging still use a chronological approach to define populations for research purposes (that is, to determine which "aged" should be studied) and to establish how people's characteristics (social, economic, health and so forth) change as a function of age. This approach may lead to an accumulation of data, but does not in itself lead to explanatory knowledge. The step from chronological time to chronological age should be taken cautiously if we want to consider aging processes seriously, especially because chronological age is widely used in contemporary societies as a basis for regulating all kinds of processes, with many consequences for individuals. The arguments presented here do not deny the finitude of human life, nor do they deny that "aging" can be observed in any individual if we compare the characteristics of that person over a relatively long period. The question is how to approach these themes to get a better understanding. To achieve this, we need to understand the specific significance and relativity of chronological time and uncover unfounded deductions about time in relation to aging. This book will be of interested to students and professors of the social sciences, humanities and aging, including the methodology of aging studies; professionals working in the field of aging, including sociologists, psychologists and biologists.

Happiness Is a Choice You Make
Happiness Is a Choice You Make

Author: John Leland

Publisher: Sarah Crichton Books

Published: 2018-01-23

Total Pages: 240

ISBN-13: 0374717052

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A New York Times Bestseller! An extraordinary look at what it means to grow old and a heartening guide to well-being, Happiness Is a Choice You Make weaves together the stories and wisdom of six New Yorkers who number among the “oldest old”— those eighty-five and up. In 2015, when the award-winning journalist John Leland set out on behalf of The New York Times to meet members of America’s fastest-growing age group, he anticipated learning of challenges, of loneliness, and of the deterioration of body, mind, and quality of life. But the elders he met took him in an entirely different direction. Despite disparate backgrounds and circumstances, they each lived with a surprising lightness and contentment. The reality Leland encountered upended contemporary notions of aging, revealing the late stages of life as unexpectedly rich and the elderly as incomparably wise. Happiness Is a Choice You Make is an enduring collection of lessons that emphasizes, above all, the extraordinary influence we wield over the quality of our lives. With humility, heart, and wit, Leland has crafted a sophisticated and necessary reflection on how to “live better”—informed by those who have mastered the art.