Prostaglandins and Thromboxanes explores the two members of the prostanoid class of fatty acid. This book attempts to thoroughly discuss the topic after collecting enough information through research in physical and biological sciences. As the title suggests, the book revolves around prostaglandins and thromboxanes. The book's first chapter contains a discussion on the subject's history, stating the year of discovery and crediting the scientist who coined the names. The chapter ends talking about the possible uses of prostaglandins and thromboxanes in the clinic. The chapters that follow discu...
This volume presents lecture notes from the session of the International School of Pharmacology, at the "Ettore Majorana" Centre, on Advances in Prostaglandins that took place in Erice (Sicily), October 4 to October 15, 1976. The School was a NATO Advanced Study Institute. The aim of this international course was a compre hensive discussion by experts in various disciplines of the present status of our knowledge of the biological role of prostaglandins and thromboxanes. The synthesis, metabolism, and function of prosta glandins have been evaluated at the cellular level, in isolated tissues, and/or in the intact organism. The mode of action of prostaglandins and their interactions, particularly with cyclic nucleotides, in normal and pathological conditions, has been discussed with the aim of understanding the possible role of these compounds in hormonal regulation and cell response. The prostaglandin biosynthetic capacity of different tissues, under various experimental conditions, in the presence of specific precursors, and the inhibitory ac tivity of different agents have been examined to ascer tain the relationship between function and metabolism. For these reasons the discussion has also been extended to the methods (biological, immunological, and spectrometric) available for the direct and specific determination of prostaglandins and the evaluation of their synthesis and metabolism. The Editors hope that the book will be useful both to beginners and to those with a long-time interest in prostaglandins. F. Berti B. Samuelsson G. P. Velo v CONTENTS Chemistry of Prostaglandins and Thromboxanes . .
One hundred papers treat advances in research of the effects and uses of prostaglandins, thromboxanes, and leukotrienes in such medical fields as organ transplantation, male erectile dysfunction, amniotic fluid infection and labour, renal function, anti-inflammatory drugs, allergic and aspirin-intolerant asthma, angioplasty and heart ischemia, Alzheimer's disease, vessel wall hyperplasia, and more. Annotation copyrighted by Book News, Inc., Portland, OR
Prostaglandins and Thromboxanes explores the two members of the prostanoid class of fatty acid. This book attempts to thoroughly discuss the topic after collecting enough information through research in physical and biological sciences. As the title suggests, the book revolves around prostaglandins and thromboxanes. The book's first chapter contains a discussion on the subject's history, stating the year of discovery and crediting the scientist who coined the names. The chapter ends talking about the possible uses of prostaglandins and thromboxanes in the clinic. The chapters that follow discuss the two lipids' basic and advanced synthesis, pharmacology, biosynthesis, biological activity, chemical interconversions, and metabolism, along with its subtopics. The book will serve as an excellent reference for undergraduate and graduate students in the related field.
