Advances in Genetics and Molecular Diagnosis in Colorectal Cancer.
Author: Jorge Melendez-Zajgla
Publisher: Frontiers Media SA
Published: 2023-10-19
Total Pages: 135
ISBN-13: 2832536115
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Genetics of Colorectal Cancer
Author: John D. Potter
Publisher: Springer
Published: 2008-12-08
Total Pages: 309
ISBN-13: 9780387095677
DOWNLOAD EBOOKGenetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.
Advances in genetics and molecular diagnosis in colorectal, stomach, and pancreatic cancer
Author: Carlos A. Vaccaro
Publisher: Frontiers Media SA
Published: 2023-01-27
Total Pages: 108
ISBN-13: 2832512127
DOWNLOAD EBOOKMolecular Pathogenesis of Colorectal Cancer
Author: Kevin M. Haigis, Ph.D.
Publisher: Springer Science & Business Media
Published: 2013-10-02
Total Pages: 319
ISBN-13: 146148412X
DOWNLOAD EBOOKColorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.
DNA Alterations in Lynch Syndrome
Author: Matjaž Vogelsang
Publisher: Springer
Published: 2013-05-25
Total Pages: 0
ISBN-13: 9789400765962
DOWNLOAD EBOOKLynch syndrome (LS) is the most common cause of inherited colorectal cancer, a disease with a high mortality rate. An estimated 37,000 of diagnosed colorectal cancer cases worldwide are attributed to Lynch syndrome each year. Intensive cancer screening, with early initiation and frequent follow-up, can reduce colorectal cancer incidence and mortality in LS patients. This book provides an up-to-date overview on the genetic and epigenetic basis of Lynch syndrome. It evaluates clinical features of the disease and critically comments on molecular tools available for identifying mutations responsible for Lynch syndrome; in addition the importance of functional assays that can help clarify the clinical nature of identified mutations is also discussed. The book also focuses on challenges in genetic counselling of at-risk individuals and discusses related ethical issues. The purpose of the book is to give a concise knowledge base for the broader scientific and medical community, including genetic counselors, in order to improve awareness on the potential impact that the diagnosis of LS has on treatment, management and surveillance of LS patients.
Hereditary Colorectal Cancer
Author: Laura Valle
Publisher: Springer
Published: 2018-05-04
Total Pages: 494
ISBN-13: 3319742590
DOWNLOAD EBOOKThis book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed. This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.
Assessing Genetic Risks
Author: Institute of Medicine
Publisher: National Academies Press
Published: 1994-01-01
Total Pages: 353
ISBN-13: 0309047986
DOWNLOAD EBOOKRaising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.
Cancer and the Environment
Author: Institute of Medicine
Publisher: National Academies Press
Published: 2002-08-01
Total Pages: 160
ISBN-13: 0309169240
DOWNLOAD EBOOKThe Roundtable on Environmental Health Sciences, Research, and Medicine wanted to address the link between environmental factors and the development of cancer in light of recent advances in genomics. They asked what research tools are needed, how new scientific information can be applied in a timely manner to reduce the burden of cancer, and how this can be flexible enough to treat the individual.
Colorectal Cancer in Clinical Practice
Author: Bernard Levin
Publisher: CRC Press
Published: 2005-11-23
Total Pages: 200
ISBN-13: 9781841844558
DOWNLOAD EBOOKThe rapid rate of development in the fields of prevention, early detection and management for colorectal cancer means that the successful first edition of this accessible guide has needed to be updated and revised throughout. Primary care physicians and specialists alike will continue to find this an indispensable synopsis of the issues and options.
Hereditary Colorectal Cancer
Author: Miguel A. Rodriguez-Bigas
Publisher: Springer Science & Business Media
Published: 2010-09-10
Total Pages: 615
ISBN-13: 144196603X
DOWNLOAD EBOOKColorectal cancer is the third most commonly diagnosed cancer in the US and the third most recently linked to cancer deaths. The national annual incidence rate of colorectal cancer is approximately 148,000+, striking slightly more females than males. The lifetime risk of colorectal cancer is 5-6%, however patients with a familial risk (with two or more first or second degree relatives) make up 20% of the patients. Persons who carry genetic mutations linked to hereditary colorectal cancer are the most likely to develop the disease.
