Adult Onset
Adult Onset

Author: Ann-Marie MacDonald

Publisher: Knopf Canada

Published: 2014-09-30

Total Pages: 374

ISBN-13: 0345808290

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From the acclaimed, bestselling author of 2 beloved classics, Adult Onset is a powerful drama about motherhood, the dark undercurrents that break and hold families together, and the power and pressures of love. Mary Rose MacKinnon--nicknamed MR or "Mister"--is a successful YA author who has made enough from her writing to semi-retire in her early 40s. She lives in a comfortable Toronto neighbourhood with her partner, Hilary, a busy theatre director, and their 2 young children, Matthew and Maggie, trying valiantly and often hilariously to balance her creative pursuits with domestic demands, and the various challenges that (mostly) solo parenting presents. As a child, Mary Rose suffered from an illness, long since cured and "filed separately" in her mind. But as her frustrations mount, she experiences a flare-up of forgotten symptoms which compel her to rethink her memories of her own childhood and her relationship with her parents. With her world threatening to unravel, the spectre of domestic violence raises its head with dangerous implications for her life and that of her own children.

Adult Onset
Adult Onset

Author: Ann-Marie MacDonald

Publisher: Hachette UK

Published: 2014-09-30

Total Pages: 361

ISBN-13: 1473610125

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'Ann-Marie MacDonald captures the dark hilarity of parenthood like nobody else. I gulped down Adult Onset in a single day.' Emma Donoghue, author of Room A NUMBER ONE BESTSELLER IN CANADA Mary Rose McKinnon has two children with her partner Hilary and a fractured relationship with her mother Dolly; she also has issues with anger management and lives in fear of hurting the children and these feelings seem somehow rooted in a part of her childhood she has trouble remembering. Is Dolly - the kind of big personality who makes all Mary Rose's friends, and even waiters in coffee shops, exclaim 'I love your Mum!' - really harbouring a dark secret about what caused Mary Rose's childhood injuries, and is Mary Rose doomed to follow the same path with her own children? ADULT ONSET is a heartbreaking, hilarious, hugely satisfying novel about family ties and the joy and agony of parenthood. Ann-Marie MacDonald gets under the reader's skin and gives voice to the feelings we have all experienced but may never have examined.

Growth Hormone Deficiency in Adults
Growth Hormone Deficiency in Adults

Author: Jens O. L. Jørgensen

Publisher: Karger Medical and Scientific Publishers

Published: 2005-01-01

Total Pages: 241

ISBN-13: 3805579926

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It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH.

Wounded By Reality
Wounded By Reality

Author: Ghislaine Boulanger

Publisher: Routledge

Published: 2011-02-25

Total Pages: 197

ISBN-13: 113687304X

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The culmination of three decades of studying and treating survivors of adult onset trauma, Wounded by Reality is the first systematic attempt to differentiate adult onset trauma from childhood trauma, with which it is frequently confused. When catastrophic events overtake adult lives, they often scar the psyche in ways that psychodynamically oriented clinicians struggle to understand. For Ghislaine Boulanger, the enormous challenge of working with these patients is unsurprising. Survivors of major catastrophe, whether a natural disaster, a life-threatening assault, a serious accident, or an act of terrorism, experience a near-fatal disruption of fundamental aspects of self experience. The sense of agency, of affectivity, of bodily integrity, the capacity for self-reflection, the sense of time, and the ability to relate to others - all are called into question.

The Way the Crow Flies
The Way the Crow Flies

Author: Ann-Marie MacDonald

Publisher: HarperCollins UK

Published: 2004

Total Pages: 756

ISBN-13: 0007171722

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Madeleine learns about the ambiguity of human morality when a murder occurs on the air force base where she lives as a child and the lessons are reinforced years later when the search for the killer is renewed.

Periodic and Non-Periodic Fevers
Periodic and Non-Periodic Fevers

Author: Rolando Cimaz

Publisher: Springer Nature

Published: 2019-10-29

Total Pages: 283

ISBN-13: 3030190552

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This book, written by very well-known opinion leaders in the field, covers all aspects of periodic and non –periodic fevers, and related disorders. The expression refers to several different auto-inflammatory diseases, showing similar symptoms–the primary symptom being a recurrent fever for an infectious cause cannot be found. The opening chapters give some historical hints, explain the genetic basis of the disease and provide insights into the pathogenesis derived from recent experimental studies and guides the reader through classification and nomenclature. A large part of the book is then devoted to a detailed description of the specific related diseases and their clinical presentations, the disease course, and potential complications in both pediatric and adult patients. The advice regarding treatment is based on the best currently available evidence in this constantly evolving area. The book is part of Springer’s series Rare Diseases of the Immune System, which presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. Autoinflammatory diseases are hereditary disorders that are caused by single-gene defects in innate immune regulatory pathways and are characterized by a clinical and biological inflammatory syndrome in which there is limited, if any, evidence of autoimmunity. Periodic and Non-Periodic Fevers will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with these disease.

Disease Control Priorities, Third Edition (Volume 4)
Disease Control Priorities, Third Edition (Volume 4)

Author: Vikram Patel

Publisher: World Bank Publications

Published: 2016-03-10

Total Pages: 307

ISBN-13: 1464804281

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Mental, neurological, and substance use disorders are common, highly disabling, and associated with significant premature mortality. The impact of these disorders on the social and economic well-being of individuals, families, and societies is large, growing, and underestimated. Despite this burden, these disorders have been systematically neglected, particularly in low- and middle-income countries, with pitifully small contributions to scaling up cost-effective prevention and treatment strategies. Systematically compiling the substantial existing knowledge to address this inequity is the central goal of this volume. This evidence-base can help policy makers in resource-constrained settings as they prioritize programs and interventions to address these disorders.

A Clinician's Pearls & Myths in Rheumatology
A Clinician's Pearls & Myths in Rheumatology

Author: John H. Stone

Publisher: Springer Science & Business Media

Published: 2009-10-03

Total Pages: 489

ISBN-13: 1848009348

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Important strides have been made in understanding the pathophysiologic basis of many inflammatory conditions in recent years, but rheumatology remains a discipline in which diagnosis is rooted in the medical history skillfully extracted from the patient, the careful physical examination, and the discriminating use of laboratory tests and imaging. Moreover, selection of the most appropriate therapy for patients with rheumatic diseases also remains heavily reliant upon clinical experience. Medical disciplines such as rheumatology that depend significantly upon clinical wisdom are prone to the development of systems of ‘Pearls’ and ‘Myths,’ related to the diseases they call their own, a ‘Pearl’ being a nugget of truth about the diagnosis or treatment of a particular disease that has been gained by dint of clinical experience and a ‘Myth’ being a commonly held belief that influences the practice of many clinicians – but is false. This book will pool together the clinical wisdom of seasoned, expert rheumatologists who participate in the care of patients with autoimmune diseases, systemic inflammatory disorders, and all other rheumatic conditions.

Adult Onset
Adult Onset

Author: Ann-Marie MacDonald

Publisher: Tin House Books

Published: 2015-04-14

Total Pages: 273

ISBN-13: 1941040063

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From the acclaimed, bestselling author of two beloved classics, Fall On Your Knees and The Way the Crow Flies, Adult Onset is a powerful drama that makes vividly real the pressures of life and love, and the undercurrents that run deep through even the most devoted families. Mary Rose MacKinnon is a successful author of YA fiction doing a tour of duty as stay-at-home mom while her partner, Hilary, takes a turn focusing on her career. She tries valiantly to balance the (mostly) solo parenting of two young children with the relentless needs of her aging parents. But amid the hilarities of full-on domesticity arises a sense of dread. Do other people notice the dents in the expensive refrigerator? How long will it take Mary Rose to realize that the car alarm that has been going off all morning is hers, and how on earth did the sharpest pair of scissors in the house wind up in her toddler’s hands? As frustrations mount, she experiences a flare-up of forgotten symptoms of a childhood illness that compel her to rethink her own upbringing, her own family history. Over the course of one outwardly ordinary week, Mary Rose’s world threatens to unravel, and the specter of violence raises its head with dangerous implications for her and her children. With humor and unerring emotional accuracy, Adult Onset explores the pleasures and pressures of family bonds, powerful and yet so easily twisted and broken. Ann-Marie MacDonald has crafted a searing, terrifying, yet ultimately uplifting story.