Acute Lung Injury and Repair
Acute Lung Injury and Repair

Author: Lynn M. Schnapp

Publisher: Humana Press

Published: 2016-11-07

Total Pages: 188

ISBN-13: 3319465279

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Acute Respiratory Distress Syndrome (ARDS) remains an important cause of morbidity and mortality worldwide, and the incidence is predicted to increase with the aging population Several clinical disorders can initiate ARDS, including pneumonia, sepsis, gastric aspiration and trauma but despite intense research over the past 40 years, we still have an incomplete understanding of the pathophysiology of the disease and treatment remains largely supportive. This book provides an overview of acute lung injury and repair, describes current animal models to study lung injury and reviews current methodologies to study and measure lung injury and repair. Special emphasis is given to state of the art techniques and methods and relevance to human disease. Acute Lung Injury and Repair: Scientific Fundamentals and Methods is a useful resource for physicians and scientists who are interested in experimental model systems for insight into ARDS pathogenesis and treatment strategies. ​

Acute Lung Injury
Acute Lung Injury

Author: Geoffrey J. Bellingan

Publisher: John Wiley & Sons

Published: 2000

Total Pages: 154

ISBN-13: 9789051995039

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This book provides a comprehensive and up to date picture of the molecular mechanisms underlying acute lung injury, focusing both on the mechanisms of injury and of repair. Topics covered include the cells involved, their injurious products including pro-inflammatory cytokines, proteases and free radical species as well as the fibrotic response and its molecular regulation, the role of the immune system, airway repair and remodelling and transcription factors regulating inflammation. All the chapters are written by experts in their field and reflect the lecture given by these authors at a recent international meeting also entitled " Acute lung injury: from inflammation to repair", held as part of the ongoing Molecular Pathology Annual symposia at University College London. The meeting gathered together a wide range of scientists and clinicians all of whom are at the cutting edge of inflammation and repair as it relates to acute lung injury. It is the breadth of approach that makes the volume so useful.

Ventilator-Induced Lung Injury
Ventilator-Induced Lung Injury

Author: Didier Dreyfuss

Publisher: CRC Press

Published: 2006-03-21

Total Pages: 776

ISBN-13: 1420019260

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This reference surveys current best practices in the prevention and management of ventilator-induced lung injury (VILI) and spans the many pathways and mechanisms of VILI including cell injury and repair, the modulation of alveolar-capillary barrier properties, and lung and systemic inflammatory consequences of injurous mechanical ventilation. Cons

Etiology and Treatment of Acute Lung Injury
Etiology and Treatment of Acute Lung Injury

Author: Sadis Matalon

Publisher: IOS Press

Published: 2001

Total Pages: 320

ISBN-13: 9781586031831

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This book contains contributions of internationally known basic scientists and clinicians with expertise in various aspects of lung injury and repair. This monogram on the pathophysiology and treatment of Acute Lung Injury contains five different sections, each one with contributions from both basic and clinical scientists, outlining existing controversies, an how they can be resolved by future multidisciplinary studies. The various sections discuss: sodium transport and fluid clearance across the normal and injured lungs, the role of the pulmonary surfactant in the pathogenesis and treatment of ARDS, mechanisms and modification of acute and chronic lung injury, ventilatory strategies for the management of acute respiratory distress syndrome and nitric oxide: friend or foe.

Lung Injury
Lung Injury

Author: Robert H. Notter

Publisher: CRC Press

Published: 2005-04-20

Total Pages: 888

ISBN-13: 9780824757939

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Progressing from general scientific principles and concepts to in-depth topical discussions of current research and treatment methods, this comprehensive reference defines the cellular and molecular mechanisms contributing to inflammatory lung injury and repair. Extensive coverage is provided on key mediators and pathways important in acute and chronic pulmonary inflammation and lung injury, as well as the mechanistic pathophysiology of related diseases ranging from clinical acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) to idiopathic pulmonary fibrosis (IPF) and other subacute and chronic conditions. Additional chapters also address vascular dysfunction, surfactant dysfunction, reactive oxygen/nitrogen species, and cell and animal models of acute and chronic lung injury.

Lung Injury
Lung Injury

Author: Ronald G. Crystal

Publisher: Lippincott Williams & Wilkins

Published: 1992

Total Pages: 424

ISBN-13:

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A comprehensive review of lung injury, defence and repair and therapeutic interventions. The text focuses on clinically relevant issues such as infections and host defences, immune injury, airborne contaminants, acute lung injury, injury from drugs, fibrotic processes and genetic modulation.

Lung Injury
Lung Injury

Author: Robert H. Notter

Publisher: CRC Press

Published: 2005-04-20

Total Pages: 888

ISBN-13: 9781135521981

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Progressing from general scientific principles and concepts to in-depth topical discussions of current research and treatment methods, this comprehensive reference defines the cellular and molecular mechanisms contributing to inflammatory lung injury and repair. Extensive coverage is provided on key mediators and pathways important in acute and chronic pulmonary inflammation and lung injury, as well as the mechanistic pathophysiology of related diseases ranging from clinical acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) to idiopathic pulmonary fibrosis (IPF) and other subacute and chronic conditions. Additional chapters also address vascular dysfunction, surfactant dysfunction, reactive oxygen/nitrogen species, and cell and animal models of acute and chronic lung injury.

The Alveolar Epithelium
The Alveolar Epithelium

Author: Michael Kasper

Publisher:

Published: 2020-09-23

Total Pages: 222

ISBN-13: 9783039431663

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Alveolar epithelial cells (AECs) of the lung are important contributors to pulmonary immune functions and to pulmonary development and alveolar repair mechanisms following lung injury. AECI, together with the capillary endothelium, form the extremely thin barrier between alveolar air and blood. AECII produce and metabolize the surface-tension lowering and immune-modulating surfactant and are the progentiors of AECI. A great variety of processes rely on their normal functioning, including maintenance of the alveolar barrier; innate immune defense; and processes of differentiation, senescence, apoptosis, and autophagy. The wide range of AEC functions is nicely reflected by the diversity of topics addressed by the four review and eight original articles contained in this Special Issue of the International Journal of Molecular Sciences. Beyond the broad spectrum of topics, the authors of this issue also made use of an impressive variety of analytical methods, thus further illustrating the fascinating diversity of aspects related to AEC biology.

Burn and Trauma Associated Lung Injury
Burn and Trauma Associated Lung Injury

Author: Zhao-fan Xia

Publisher: Springer Nature

Published: 2021-02-02

Total Pages: 183

ISBN-13: 9811570566

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This book provides in-depth analysis and guidance in the clinical diagnosis and treatment, and development of new treatments with clinical applied prospect of burn and trauma associated lung injury. It includes study on the pathological change of burn and trauma associated lung injury such as inhalation injury, lung blast injury, pulmonary barotrauma, delayed hemopneumothorax, lung injury associated sepsis, ventilator-induced lung injury and ischemia-reperfusion lung injury. It is also compiled with many clinical typical cases, full data and series of pictures. It also aims at bringing more clinicians’ attention to burn-/trauma-induced lung injury, making them familiar with the relevant theories and clinical diagnose; guiding the treatment of burn and trauma associated lung injury and improving the prognosis and life quality of patients; stimulating more clinicians and researchers to further explore the pathological mechanism and new treatments of burn and trauma associated lung injury. It persists in combining theory and practice, and highlights practical application to reflect the theoretical value. It is very suitable for the medical teaching and can also be used as a reference book for medical doctoral students, postgraduates, and medical trainees receiving continuing education from critical care medicine, burn & trauma surgery, and emergency medicine.