Clinical Pharmacology: Current Topics and Case Studies
Clinical Pharmacology: Current Topics and Case Studies

Author: Markus Müller

Publisher: Springer Science & Business Media

Published: 2011-02-04

Total Pages: 438

ISBN-13: 3709101441

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Today we witness an eventful time in which the powerful new forces of genomics, information technology and economics are rapidly changing the science and art of medicine. This will require more specialization than ever before. However, there is also an increasing demand for an integrated approach, which is provided by the discipline of Clinical Pharmacology (CP). CP pursues a scientific goal by studying drug action in patients and volunteers, a clinical goal by administering appropriate drug therapy and a regulatory goal by assessing the risk/benefit ratio of drug candidates in drug development and reimbursement. This introduction to current topics of CP covers traditional topics of clinical drug research and trial methodology but also provides insight in current topics like genomics, imaging technology and issues in drug reimbursement. A number of concrete case studies in clinical drug research and development help to give a better understanding of the general principles of CP.

Drug-Drug Interactions for Therapeutic Biologics
Drug-Drug Interactions for Therapeutic Biologics

Author: Honghui Zhou

Publisher: John Wiley & Sons

Published: 2013-05-10

Total Pages: 272

ISBN-13: 1118630211

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Strategize, plan, and execute comprehensive drug-drug interaction assessments for therapeutic biologics Offering both theory and practical guidance, this book fully explores drug-drug interaction assessments for therapeutic biologics during the drug development process. It draws together and analyzes all the latest findings and practices in order to present our current understanding of the topic and point the way to new research. Case studies and examples, coupled with expert advice, enable readers to better understand the complex mechanisms of biologic drug-drug interactions. Drug-Drug Interactions for Therapeutic Biologics features contributions from leading international experts in all areas of therapeutic biologics drug development and drug-drug interactions. The authors' contributions reflect a thorough review and analysis of the literature as well as their own firsthand laboratory experience. Coverage includes such essential topics as: Drug-drug interaction risks in combination with small molecules and other biologics Pharmacokinetic and pharmacodynamic drug-drug interactions In vitro methods for drug-drug interaction assessment and prediction Risk-based strategies for evaluating biologic drug-drug interactions Strategies to minimize drug-drug interaction risk and mitigate toxic interactions Key regulations governing drug-drug interaction assessments for therapeutic biologics. Drug-Drug Interactions for Therapeutic Biologics is recommended for pharmaceutical and biotechnology scientists, clinical pharmacologists, medicinal chemists, and toxicologists. By enabling these readers to understand how therapeutic biologics may interact with other drugs, the book will help them develop safer, more effective therapeutic biologics.

The ESC Handbook on Cardiovascular Pharmacotherapy
The ESC Handbook on Cardiovascular Pharmacotherapy

Author: Juan Carlos Kaski

Publisher:

Published: 2019

Total Pages: 961

ISBN-13: 0198759932

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The ESC Handbook on Cardiovascular Pharmacotherapy, based on the most recent guidelines in cardiovascular pharmacology, and containing a comprehensive A-Z formulary of common and less commonly used cardiac drugs and drug groups, provides practical and accessible guidance on all areas of drug prescribing.

Translational Biomedical Informatics
Translational Biomedical Informatics

Author: Bairong Shen

Publisher: Springer

Published: 2016-10-31

Total Pages: 331

ISBN-13: 9811015031

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This book introduces readers to essential methods and applications in translational biomedical informatics, which include biomedical big data, cloud computing and algorithms for understanding omics data, imaging data, electronic health records and public health data. The storage, retrieval, mining and knowledge discovery of biomedical big data will be among the key challenges for future translational research. The paradigm for precision medicine and healthcare needs to integratively analyze not only the data at the same level – e.g. different omics data at the molecular level – but also data from different levels – the molecular, cellular, tissue, clinical and public health level. This book discusses the following major aspects: the structure of cross-level data; clinical patient information and its shareability; and standardization and privacy. It offers a valuable guide for all biologists, biomedical informaticians and clinicians with an interest in Precision Medicine Informatics.

Drug-Acceptor Interactions
Drug-Acceptor Interactions

Author: Niels Bindslev

Publisher: CRC Press

Published: 2017-02-10

Total Pages: 847

ISBN-13: 1351660578

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Drug-Acceptor Interactions: Modeling theoretical tools to test and evaluate experimental equilibrium effects suggests novel theoretical tools to test and evaluate drug interactions seen with combinatorial drug therapy. The book provides an in-depth, yet controversial, exploration of existing tools for analysis of dose-response studies at equilibrium or steady state. The book is recommended reading for post-graduate students and researchers engaged in the study of systems biology, networks, and the pharmacodynamics of natural or industrial drugs, as well as for medical clinicians interested in drug application and combinatorial drug therapy. Even people without mathematical skills will be able to follow the pros and cons of reaction schemes and their related distribution equations. Chapter 9 is a hands-on guide for software to plot, fit and analyze one’s own data.

Drug-Drug Interactions
Drug-Drug Interactions

Author: A. David Rodrigues

Publisher: CRC Press

Published: 2019-01-03

Total Pages: 769

ISBN-13: 0849375940

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Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:key interplay between transporters and enzymes

A Case Approach to Perioperative Drug-Drug Interactions
A Case Approach to Perioperative Drug-Drug Interactions

Author: Catherine Marcucci

Publisher: Springer

Published: 2015-09-15

Total Pages: 943

ISBN-13: 1461474957

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The occurrence of deleterious or even fatal drug-drug interactions (DDIs) in the perioperative period is no longer a theoretical concern but a harrowing reality. A Case Approach to Perioperative Drug-Drug Interactions addresses the complex realm of pharmacokinetic drug interactions in an easy-to-read volume that functions as both a comprehensive clinical reference and a casebook. The book presents a summary of the core concepts of drug interactions; an organized, annotated presentation of the drug interactions most relevant to the perioperative clinician; and approximately 200 case scenarios that highlight specific drug interactions. This book fills a real void in the clinical literature and is invaluable to anesthesiologists and surgeons, as well as trainees in both specialties; intensive care staff, including physicians, physician’s assistants, and nurses; and nurse practitioners who staff preoperative evaluation clinics.

Davies's Textbook of Adverse Drug Reactions
Davies's Textbook of Adverse Drug Reactions

Author: David Margerison Davies

Publisher: Hodder Education

Published: 1998

Total Pages: 998

ISBN-13:

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In recent years, a vast amount has been written on adverse drug reactions, yet this surfeit of information has made it more difficult for clinicians to obtain umambiguous answers to their questions. This book provides a "map" for clinicians to find their way through the jungle of tocicological fact and theory. Comprehensive yet succinct, the text deals with matters of fundamental importance, with five new chapters, and extensive revisions of chapters in previous editions. The approach by clinical feature rather than by drug matches the way the problem presents itself to the clinician. This will be invaluable, user-friendly resource for all clinicians.

Botanical Dietary Supplements:
Botanical Dietary Supplements:

Author: Gail B. Mahady

Publisher: CRC Press

Published: 2001-06-01

Total Pages: 288

ISBN-13: 9789026518553

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This volume provides reviews and details of the quality, safety and efficacy for some of the top-selling botanicals worldwide, including black cohosh, chamomile, comfrey, echinacea, garlic, ginkgo, ginseng, kava, milk thistle, St John's wort and valerian. The work was written based on a systematic review of the scientific literature from 1975-2000.;Each review includes a brief introduction, a section on quality including a definition of the crude drug, geographical distribution, and a listing of the major chemical constituents. The safety and efficacy sections summarize the medical uses, pharmacology, contraindications, warnings, precautions, adverse reactions, dose and dosage forms. The safety and efficacy sections were written for a busy health-care professional, and should enable one to ascertain which clinical uses are supported by clinical data, without having to read through all the pharmacology. Each chapter is fully referenced, enabling the reader to access further information when necessary.