"A concise account of what we know about development discusses the first vital steps of growth and explores one of the liveliest areas of scientific research."--P. [2] of cover.
"Fundamentals of Tissue Engineering and Regenerative Medicine" provides a complete overview of the state of the art in tissue engineering and regenerative medicine. Tissue engineering has grown tremendously during the past decade. Advances in genetic medicine and stem cell technology have significantly improved the potential to influence cell and tissue performance, and have recently expanded the field towards regenerative medicine. In recent years a number of approaches have been used routinely in daily clinical practice, others have been introduced in clinical studies, and multitudes are in the preclinical testing phase. Because of these developments, there is a need to provide comprehensive and detailed information for researchers and clinicians on this rapidly expanding field. This book offers, in a single volume, the prerequisites of a comprehensive understanding of tissue engineering and regenerative medicine. The book is conceptualized according to a didactic approach (general aspects: social, economic, and ethical considerations; basic biological aspects of regenerative medicine: stem cell medicine, biomolecules, genetic engineering; classic methods of tissue engineering: cell, tissue, organ culture; biotechnological issues: scaffolds; bioreactors, laboratory work; and an extended medical discipline oriented approach: review of clinical use in the various medical specialties). The content of the book, written in 68 chapters by the world’s leading research and clinical specialists in their discipline, represents therefore the recent intellect, experience, and state of this bio-medical field.
Providing students and practitioners with a detailed overview of the key theoretical and applied issues, this book is a comprehensive and integrated primer on regeneration. The various chapters: review the history and context of urban regeneration; consider funding implications; look at environmental, social and community issues, as well as employment, education and training; focus on managing urban regeneration; consider land use issues; and discuss monitoring and evaluation. The book concludes with a comparative analysis, with examples from America and Europe, and a discussion of future trends. The book represents the first systematic overview of urban regeneration in one volume and is set to become the standard referenc
This unique volume presents the recent advances in tissue regeneration. The authors are all active researchers in their respective fields with extensive experiences. The focus of the book is on the use of stem cells and nano-structured biomaterials for tissue regeneration/tissue engineering. It includes the use of stem cells, naturally derived extracellular matrix (ECM), synthetic biomimetic nano-fibers, synthetic nano-structured ceramics and synthetic nano-structured polymer/ceramic composites that can help/promote tissue regeneration. Methods on how to produce these nano-structured biomaterials are also discussed in several chapters. Future challenges and perspectives in the field of regenerative medicine (tissue regeneration) are also discussed.
This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules.
“Calls to mind such early moderns as Hemingway and Fitzgerald...Some of the most powerful antiwar literature in modern English fiction.”—The Boston Globe The first book of the Regeneration Trilogy—a Booker Prize nominee and one of Entertainment Weekly’s 100 All-Time Greatest Novels. In 1917 Siegfried Sasson, noted poet and decorated war hero, publicly refused to continue serving as a British officer in World War I. His reason: the war was a senseless slaughter. He was officially classified "mentally unsound" and sent to Craiglockhart War Hospital. There a brilliant psychiatrist, Dr. William Rivers, set about restoring Sassoon’s “sanity” and sending him back to the trenches. This novel tells what happened as only a novel can. It is a war saga in which not a shot is fired. It is a story of a battle for a man's mind in which only the reader can decide who is the victor, who the vanquished, and who the victim. One of the most amazing feats of fiction of our time, Regeneration has been hailed by critics across the globe. More than one hundred years since World War I, this book is as timely and relevant as ever.
Urban regeneration is often regarded as the process of renewal or redevelopment of spaces and places. There is a need to look at tourism and urban regeneration with a particular focus on cultural heritage. Cultural heritage consists of tangible heritage (such as historic buildings) and intangible heritage (such as events). The wider need and impact for such work is that places plan for change to keep up with the shifts in demand in the global economy in order for places to maintain a competitive advantage. Moreover, places need to keep up with the pace of global change or they risk stagnation and decline as increased competition is resulting in increased opportunities and choice for consumers. Each chapter in this book explores a specific form of cultural heritage that is driving change in urban spaces. Intended for a wide readership, the book will appeal to students of urban studies, human geography, heritage studies and international tourism management, as well as experts conducting research in and across these areas.
Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. - Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology - The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine - New discoveries from leading researchers on restoration of diseased tissues and organs