A History of Immunology
A History of Immunology

Author: Arthur M. Silverstein

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 445

ISBN-13: 0080925839

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This is a professional-level intellectual history of the development of immunology from about 1720 to about 1970. Beginning with the work and insights of the early immunologists in the 18th century, Silverstein traces the development of the major ideas which have formed immunology down to the maturation of the discipline in the decade following the Second World War. Emphasis is placed on the philosophic and sociologic climate of the scientific milieu in which immunology has developed, providing a background to the broad culture of the discipline. - A professional-level intellectual history of the development of immunology from about 1720 to 1970, with emphasis placed on the social climate of the scientific milieu in which modern immunology evolved - Written by an author very well known both as a historian of medical science and for his substantial research contributions to the immunopathology of the eye - The only complete history of immunology available

A History of Modern Immunology
A History of Modern Immunology

Author: Zoltan A. Nagy

Publisher: Academic Press

Published: 2013-10-11

Total Pages: 357

ISBN-13: 0124201083

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A History of Modern Immunology: A Path Toward Understanding describes, analyzes, and conceptualizes several seminal events and discoveries in immunology in the last third of the 20th century, the era when most questions about the biology of the immune system were raised and also found their answers. Written by an eyewitness to this history, the book gives insight into personal aspects of the important figures in the discipline, and its data driven emphasis on understanding will benefit both young and experienced scientists. This book provides a concise introduction to topics including immunological specificity, antibody diversity, monoclonal antibodies, major histocompatibility complex, antigen presentation, T cell biology, immunological tolerance, and autoimmune disease. This broad background of the discipline of immunology is a valuable companion for students of immunology, research and clinical immunologists, and research managers in the pharmaceutical and biotechnology industries. - Contains the history of major breakthroughs in immunology featured with authenticity and insider details - Gives an insight into personal aspects of the players in the history of immunology - Enables the reader to recognize and select data of heuristic value which elucidate important facets of the immune system - Provides good examples and guidelines for the recognition and selection of what is important for the exploration of the immune system - Gives clear separation of descriptive and interpretive parts, allowing the reader to distinguish between facts and analysis provided by the author

A Historical Perspective on Evidence-Based Immunology
A Historical Perspective on Evidence-Based Immunology

Author: Edward J. Moticka

Publisher: Newnes

Published: 2015-11-25

Total Pages: 396

ISBN-13: 0123983754

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A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells. - Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles - Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology - Presents concepts such as the division of lymphocytes into functionally different populations in their historical context - Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells

Metchnikoff and the Origins of Immunology
Metchnikoff and the Origins of Immunology

Author: Alfred I. Tauber

Publisher: Oxford University Press

Published: 1991-07-25

Total Pages: 276

ISBN-13: 019534510X

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This fascinating intellectual history is the first critical study of the work of Elie Metchnikoff, the founding father of modern immunology. Metchnikoff authored and championed the theory that phagocytic cells actively defend the host body against pathogens and diseased cells. His program developed from comparative embryological studies that sought to establish genealogical relations between species at the dawn of the Darwinian revolution. In this scientific biography, Tauber and Chernyak explore ore Metchnikoff's development as an embryologist, showing how it prepared him to propose his theory of host-pathogen interaction. They discuss the profound impact of Darwin's theory of evolution on Metchnikoff's progress, and the influence of 19th century debates on vitalism, teleology, and mechanism. As a case study of scientific discovery, this work offers lucid insight into the process of creative science and its dependence on cultural and philosophic sources. Immunologists and historians of science and medicine will find it an absorbing and accessible account of a remarkable individual.

The Age of Immunology
The Age of Immunology

Author: A. David Napier

Publisher: University of Chicago Press

Published: 2010-12-15

Total Pages: 344

ISBN-13: 0226568148

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In this fascinating and inventive work, A. David Napier argues that the central assumption of immunology—that we survive through the recognition and elimination of non-self—has become a defining concept of the modern age. Tracing this immunological understanding of self and other through an incredibly diverse array of venues, from medical research to legal and military strategies and the electronic revolution, Napier shows how this defensive way of looking at the world not only destroys diversity but also eliminates the possibility of truly engaging difference, thereby impoverishing our culture and foreclosing tremendous opportunities for personal growth. To illustrate these destructive consequences, Napier likens the current craze for embracing diversity and the use of politically correct speech to a cultural potluck to which we each bring different dishes, but at which no one can eat unless they abide by the same rules. Similarly, loaning money to developing nations serves as a tool both to make the peoples in those nations more like us and to maintain them in the nonthreatening status of distant dependents. To break free of the resulting downward spiral of homogenization and self-focus, Napier suggests that we instead adopt a new defining concept based on embryology, in which development and self-growth take place through a process of incorporation and transformation. In this effort he suggests that we have much to learn from non-Western peoples, such as the Balinese, whose ritual practices require them to take on the considerable risk of injecting into their selves the potential dangers of otherness—and in so doing ultimately strengthen themselves as well as their society. The Age of Immunology, with its combination of philosophy, history, and cultural inquiry, will be seen as a manifesto for a new age and a new way of thinking about the world and our place in it.

History of the Basel Institute for Immunology
History of the Basel Institute for Immunology

Author: Ivan Lefkovits

Publisher:

Published: 2017

Total Pages: 402

ISBN-13: 9783318059342

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Lectures, Parties, and Nobel Prizes: living and researching at the Basel Institute for Immunology By the early seventies of the 20th century, the Basel Institute for Immunology had become one of the largest - and certainly the most prominent - immunology institutes in the world. Its lean structure was highly successful, and the quality of the research and its reputation remained outstandingly high throughout the three decades it existed. This book describes the institute's history from its conception and the laying of the foundation stone in 1969 by the pharmaceutical company Roche to the triumph of three Nobel Prizes (1984 and 1987) for Niels K. Jerne, Georges K�hler and Susumu Tonegawa. Can all this be portrayed to make the layman understand it and the scientist relish it? Indeed, the book succeeds in tuning in to what fascinates students, advanced researchers and scientists, historians, policy makers and philanthropists alike. The narrative reveals many aspects of the institute's life and also describes all its research and achievements. Immunologists at every level, from beginners to old hands, will find something of interest to them in this history, and some readers will even make use of the huge database (documents, pictures and films) linked to the book by hundreds of QR codes.

Immunology Made Ridiculously Simple
Immunology Made Ridiculously Simple

Author: Massoud Mahmoudi

Publisher:

Published: 2009

Total Pages: 0

ISBN-13: 9780940780897

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A brief overview of the basic science and clinical aspects of immunology. The basic science section is a clear presentation of innate and adaptive immunity, immune cells, antibodies and antigens, and other components of the immune system and their interactions. The clinical section clarifies hypersensitivity, autoimmunity, immunodeficiency, common diagnostic tests, vaccination, transplantation, and tumor immunology.

Between Hope and Fear
Between Hope and Fear

Author: Michael Kinch

Publisher: Simon and Schuster

Published: 2018-07-03

Total Pages: 486

ISBN-13: 1681778203

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If you have a child in school, you may have heard stories of long-dormant diseases suddenly reappearing—cases of measles, mumps, rubella, and whooping cough cropping up everywhere from elementary schools to Ivy League universities because a select group of parents refuse to vaccinate their children. Between Hope and Fear tells the remarkable story of vaccine-preventable infectious diseases and their social and political implications. While detailing the history of vaccine invention, Kinch reveals the ominous reality that our victories against vaccine-preventable diseases are not permanent—and could easily be undone. In the tradition of John Barry’s The Great Influenza and Siddhartha Mukherjee’s The Emperor of All Maladies, Between Hope and Fear relates the remarkable intersection of science, technology, and disease that has helped eradicate many of the deadliest plagues known to man.

Avian Immunology
Avian Immunology

Author: Bernd Kaspers

Publisher: Academic Press

Published: 2012-12-02

Total Pages: 456

ISBN-13: 0123972728

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The second edition of Avian Immunology provides an up-to-date overview of the current knowledge of avian immunology. From the ontogeny of the avian immune system to practical application in vaccinology, the book encompasses all aspects of innate and adaptive immunity in chickens. In addition, chapters are devoted to the immunology of other commercially important species such as turkeys and ducks, and to ecoimmunology summarizing the knowledge of immune responses in free-living birds often in relation to reproductive success. The book contains a detailed description of the avian innate immune system, encompassing the mucosal, enteric, respiratory and reproductive systems. The diseases and disorders it covers include immunodepressive diseases and immune evasion, autoimmune diseases, and tumors of the immune system. Practical aspects of vaccination are examined as well. Extensive appendices summarize resources for scientists including cell lines, inbred chicken lines, cytokines, chemokines, and monoclonal antibodies. The world-wide importance of poultry protein for the human diet, as well as the threat of avian influenza pandemics like H5N1 and heavy reliance on vaccination to protect commercial flocks makes this book a vital resource. This book provides crucial information not only for poultry health professionals and avian biologists, but also for comparative and veterinary immunologists, graduate students and veterinary students with an interest in avian immunology. - With contributions from 33 of the foremost international experts in the field, this book provides the most up-to-date review of avian immunology so far - Contains a detailed description of the avian innate immune system reviewing constitutive barriers, chemical and cellular responses; it includes a comprehensive review of avian Toll-like receptors - Contains a wide-ranging review of the "ecoimmunology" of free-living avian species, as applied to studies of population dynamics, and reviews methods and resources available for carrying out such research

Basics and Fundamentals of Immunology
Basics and Fundamentals of Immunology

Author: Manzoor Ahmad Mir

Publisher:

Published: 2020

Total Pages: 0

ISBN-13: 9781536166392

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Immunology is a distinctive subject that rose in the mid-20th century. The subject developed as scientists started to unravel the mysteries about the defense system against pathogens. Researchers started to understand the mechanisms employed by the innate and the adaptive immune system in defense against pathogens. During the last decade, the subject of immunology has been in sharp focus as the immunotherapies against diseases like cancer and AIDS seems last hope. Employing the body's own defense system against diseases like cancer and AIDS by activating specific cells of the immune system looks promising, and therapies like CAR-T cell therapy have been approved. In the first edition of the book "The Fundamentals of Immunology" we have explained the basics of the defense system of our body.The book is organised into four volumes. The first volume comprises of ten chapters and it describes the rise, history and scope of immunology and the building blocks of the immune system viz., cells, molecules and organs of the immune system. The second chapter describes the cells of the innate and the adaptive immune system and how the granulocytes and macrophages employ defense mechanisms to protect the body against pathogenic invasions. In the third chapter of this book, we have described the organs of the immune systems and how different organs are involved in the differentiation and maturation of immune cells. The chapter also focused on the structure of lymph nodes and their function in concentrating the antigens. In chapter four of this book, we have described the terms like antigens, immunogens, antigenicity, immunogenicity and how immunogenicity of an antigen is affected and how antigenicity of an immunogens is related to the immune response. The innate and adaptive immune systems and the different types of cells and molecules employed by the two branches of immunity have been described in a separate chapter. The structure and biology of immunoglobulins, their types and function in antigen binding and antibody dependent cellular cytotoxicity (ADCC) have been described well in chapter six. Focus has been laid on the distinction between an antibody and an immunoglobulin. The structure and function and major histocompatibility complex (MHC) has been described. The education of cells about self and non-self during their maturation and the processing and presentation of antigens by MHC bearing cells and how MHC coordinates both humoral and cell-mediated immune responses has been explained well throughout the book. The book has explained the complement system and its components, mechanisms and functions in a separate chapter. At the end of the book, we have given an insight about the vaccines, their history, development and how they are useful and helpful in the defense against diseases. The book also discusses the immune disfunction and diseases associated with the dysregulation of immune responses.