Forging an intense friendship in their senior year at Harvard, Ed, a Jewish scholarship student, and Hugh, a Boston Brahmin, abruptly and mysteriously go their separate ways years later and pursue very different lives that are shaped by their past bond.
Nearly everyone would agree that humans and their societies evolved by natural selection, that humans are biologically a single species but societies vary greatly, and neither genetic inheritance nor cultural inheritance alone can fully explain humans and their social systems. While there is a literature that addresses dual inheritance theory or the coevolution of culture and genetics, almost all of it is written from a perspective that accepts the neo-Darwinian evolutionary framework but does not give proper weight to social and cultural theory as it has been developed by cultural anthropologists. At the same time, cultural anthropologists have ignored the question of dual inheritance altogether, leaving the theorizing of how it works almost exclusively in the hands of those with a strong biological viewpoint. In this book anthropologist and psychoanalyst Robert Paul attempts to reconcile evolutionary and cultural approaches in anthropology through a comparative ethnographic exploration of how humans receive behavioral instructions from two separate channelsthe genetic code carried in the DNA and the symbolic systems that constitute culture. He develops a dual inheritance model that aims to do justice to both the genetic and cultural channels of inheritance. Paul elaborates his model of the relationship between genes and cultural symbols and then shows how it can make sense of both the similarities and variations found in human social life as captured in the now very extensive ethnographic record. He argues that cultural systems evolve to manage intra-group competition that would ensue from the genetic program pursuing its interests. The book uses thick descriptions and heavy interpretations from the ethnographic record to demonstrate how different societies tackle this challenge. The book fills a niche, connecting the dual-inheritance literature and symbolic cultural anthropology, using insights from the former to detect patterns in the latter. This is a rare and well-researched project, and should receive a broad readership among biological and cultural anthropologists, and students of human nature more broadly."
“A madcap genealogical adventure . . . Vonnegut is a postmodern Mark Twain.”—The New York Times Book Review Galápagos takes the reader back one million years, to A.D. 1986. A simple vacation cruise suddenly becomes an evolutionary journey. Thanks to an apocalypse, a small group of survivors stranded on the Galápagos Islands are about to become the progenitors of a brave, new, and totally different human race. In this inimitable novel, America’ s master satirist looks at our world and shows us all that is sadly, madly awry–and all that is worth saving. Praise for Galápagos “The best Vonnegut novel yet!”—John Irving “Beautiful . . . provocative, arresting reading.”—USA Today “A satire in the classic tradition . . . a dark vision, a heartfelt warning.”—The Detroit Free Press “Interesting, engaging, sad and yet very funny . . . Vonnegut is still in top form. If he has no prescription for alleviating the pain of the human condition, at least he is a first-rate diagnostician.”—Susan Isaacs, Newsday “Dark . . . original and funny.”—People “A triumph of style, originality and warped yet consistent logic . . . a condensation, an evolution of Vonnegut’s entire career, including all the issues and questions he has pursued relentlessly for four decades.”—The Philadelphia Inquirer “Wild details, wry humor, outrageous characters . . . Galápagos is a comic lament, a sadly ironic vison.”—St. Louis Post-Dispatch “A work of high comedy, sadness and imagination.”—The Denver Post “Wacky wit and irreverent imagination . . . and the full range of technical innovations have made [Vonnegut] America’s preeminent experimental novelist.”—The Minneapolis Star and Tribune
For readers of Rules of Civility and The Marriage Plot, Joanna Hershon’s A Dual Inheritance is an engrossing novel of passion, friendship, betrayal, and class—and their reverberations across generations. Autumn 1962: Ed Cantowitz and Hugh Shipley meet in their final year at Harvard. Ed is far removed from Hugh’s privileged upbringing as a Boston Brahmin, yet his drive and ambition outpace Hugh’s ambivalence about his own life. These two young men form an unlikely friendship, bolstered by a fierce shared desire to transcend their circumstances. But in just a few short years, not only do their paths diverge—one rising on Wall Street, the other becoming a kind of global humanitarian—but their friendship ends abruptly, with only one of them understanding why. Can a friendship define your view of the world? Spanning from the Cuban Missile Crisis to the present-day stock market collapse, with locations as diverse as Dar es Salaam, Boston, Shenzhen, and Fishers Island, A Dual Inheritance asks this question, as it follows not only these two men, but the complicated women in their vastly different lives. And as Ed and Hugh grow farther and farther apart, they remain uniquely—even surprisingly—connected. Look for special features inside. Join the Random House Reader’s Circle for author chats and more. “A big, captivating sweep of a romance . . . a searching exploration of class and destiny in late-twentieth-century America.”—Jennifer Egan “The best book about male friendship written this young century.”—Details “[A] warm, smart, enjoyably complex novel . . . Both Hugh and Ed are lonely searchers . . . and [Hershon’s] skill in rendering each of them as flawed individuals is what makes the novel so readable and so rich. . . . A Dual Inheritance is an old-fashioned social novel that feels fresh because of its deft, clear-eyed approach to still-unspoken rules about ethnicity, money and identity.”—San Francisco Chronicle “An absorbing, fully-realized novel . . . [Hershon] renders the book’s many locales with a nuanced appreciation for the way environment emerges out of the confluence of physical detail and social experience. . . . A Dual Inheritance never lets its readers forget they are reading a well-crafted novel, and as a well-crafted novel, it fully satisfies.”—The Boston Globe “This marvelous novel is a mix of heartache and history. . . . Think of Anne Tyler and Tom Wolfe, both.”—Victor LaValle, author of The Devil in Silver “[An] engrossing saga.”—Vogue “Hershon artfully guides us through the lives of Ed and Hugh, college buddies who meet at Harvard in the ’60s, shifting between their perspectives through adulthood to detail their lingering impact on one another’s lives in such a way that it’ll make you take a second look at all of your relationships.”—GQ “Let this story of two Harvard men’s unexpected friendship and its sudden end transport you through time (beginning on Harvard’s campus in 1962) and place.”—The Huffington Post “A richly composed . . . portrait of familial gravity and the wobbly orbits that bring us together again and again.”—Kirkus Reviews
DNA Methylation: Approaches, Methods and Applications describes the relation DNA methylation has to gene silencing in disease, and explores its promising role in treating cancer. Written by leaders in the field, this exceptional compilation of articles outlines the best techniques to use when addressing questions concerning the cytosine methylation
Current knowledge of the genetic, epigenetic, behavioural and symbolic systems of inheritance requires a revision and extension of the mid-twentieth-century, gene-based, 'Modern Synthesis' version of Darwinian evolutionary theory. We present the case for this by first outlining the history that led to the neo-Darwinian view of evolution. In the second section we describe and compare different types of inheritance, and in the third discuss the implications of a broad view of heredity for various aspects of evolutionary theory. We end with an examination of the philosophical and conceptual ramifications of evolutionary thinking that incorporates multiple inheritance systems.
How do biological, psychological, sociological, and cultural factors combine to change societies over the long run? Boyd and Richerson explore how genetic and cultural factors interact, under the influence of evolutionary forces, to produce the diversity we see in human cultures. Using methods developed by population biologists, they propose a theory of cultural evolution that is an original and fair-minded alternative to the sociobiology debate.
This gripping story of the doctors at the forefront of Alzheimer’s research and the courageous North Dakota family whose rare genetic code is helping to understand our most feared diseases is “excellent, accessible...A science text that reads like a mystery and treats its subjects with humanity and sympathy” (Library Journal, starred review). Every sixty-nine seconds, someone is diagnosed with Alzheimer’s disease. Of the top ten killers, it is the only disease for which there is no cure or treatment. For most people, there is nothing that they can do to fight back. But one family is doing all they can. The DeMoe family has the most devastating form of the disease that there is: early onset Alzheimer’s, an inherited genetic mutation that causes the disease in one hundred percent of cases, and has a fifty percent chance of being passed onto the next generation. Of the six DeMoe children whose father had it, five have inherited the gene; the sixth, daughter Karla, has inherited responsibility for all of them. But rather than give up in the face of such news, the DeMoes have agreed to spend their precious, abbreviated years as part of a worldwide study that could utterly change the landscape of Alzheimer’s research and offers the brightest hope for future treatments—and possibly a cure. Drawing from several years of in-depth research with this charming and upbeat family, journalist Niki Kapsambelis tells the story of Alzheimer’s through the humanizing lens of these ordinary people made extraordinary by both their terrible circumstances and their bravery. “A compelling narrative…and an educational and emotional chronicle” (Kirkus Reviews, starred review), their tale is intertwined with the dramatic narrative history of the disease, the cutting-edge research that brings us ever closer to a possible cure, and the accounts of the extraordinary doctors spearheading these groundbreaking studies. From the oil fields of North Dakota to the jungles of Colombia, this inspiring race against time redefines courage in the face of this most pervasive and mysterious disease.
After her mother's mysterious death, a young woman is summoned to the floating city of Sky in order to claim a royal inheritance she never knew existed in the first book in this award-winning fantasy trilogy from the NYT bestselling author of The Fifth Season. Yeine Darr is an outcast from the barbarian north. But when her mother dies under mysterious circumstances, she is summoned to the majestic city of Sky. There, to her shock, Yeine is named an heiress to the king. But the throne of the Hundred Thousand Kingdoms is not easily won, and Yeine is thrust into a vicious power struggle with cousins she never knew she had. As she fights for her life, she draws ever closer to the secrets of her mother's death and her family's bloody history. With the fate of the world hanging in the balance, Yeine will learn how perilous it can be when love and hate -- and gods and mortals -- are bound inseparably together.
Perfect for fans of Alice Hoffman, Isabel Allende, and Sarah Addison Allen, this is a gorgeously written novel about a family searching for the truth hidden in their past and the power they’ve inherited, from the author of the acclaimed and “giddily exciting” (The New York Times Book Review) Brooklyn Brujas series. The Montoyas are used to a life without explanations. They know better than to ask why the pantry never seems to run low or empty, or why their matriarch won’t ever leave their home in Four Rivers—even for graduations, weddings, or baptisms. But when Orquídea Divina invites them to her funeral and to collect their inheritance, they hope to learn the secrets that she has held onto so tightly their whole lives. Instead, Orquídea is transformed, leaving them with more questions than answers. Seven years later, her gifts have manifested in different ways for Marimar, Rey, and Tatinelly’s daughter, Rhiannon, granting them unexpected blessings. But soon, a hidden figure begins to tear through their family tree, picking them off one by one as it seeks to destroy Orquídea’s line. Determined to save what’s left of their family and uncover the truth behind their inheritance, the four descendants travel to Ecuador—to the place where Orquídea buried her secrets and broken promises and never looked back. Alternating between Orquídea’s past and her descendants’ present, The Inheritance of Orquídea Divina is an enchanting novel about what we knowingly and unknowingly inherit from our ancestors, the ties that bind, and reclaiming your power.