This report presents a cost analysis of 3-Hydroxypropionic Acid (3-HP) production from glucose syrup using a fermentation process. The process examined is similar to Cargill process. In this process, a 70 wt% glucose-water syrup is used as raw material. A 60 wt% 3-HP solution in water is generated as final product. This report was developed based essentially on the following reference(s): (1) US Patent 7186856, issued to Cargill in 2007 (2) US Patent 8883464, issued to Opx Biotechnologies in 2014 (3) US Patent 20160031792, issued to Cargill in 2016 Keywords: Dextrose, Aerobic Fermentation, Salt-Splitting, Acrylic Acid, Tridecylamine
This report presents a cost analysis of Ester-Grade Acrylic Acid (EAA) production from chemical grade (CG) propylene. The process examined is a typical propylene oxidation. In this process, propylene passes through a two-stage vapor phase oxidation to generate an acrylic acid-containing gas, from which acrylic acid is recovered via absorption in water. The aqueous acrylic acid solution is purified via light solvent extraction to Ester-grade Acrylic Acid (EAA), which is used in the production of acrylic esters. This report was developed based essentially on the following reference(s): "Acrylic Acid", Ullmann's Encyclopedia of Industrial Chemistry, 7th edition Keywords: Propene, Air Oxidation, Propenoic Acid, Nippon Shokubai, Rohm & Haas, Dow
This report presents a cost analysis of 3-Hydroxypropionic Acid (3-HP) production from glucose syrup using a fermentation process. The process examined is similar to Cargill process. In this process, a 70 wt% glucose-water syrup is used as raw material. This report examines one-time costs associated with the construction of a United States-based plant and the continuing costs associated with the daily operation of such a plant. More specifically, it discusses: * Capital Investment, broken down by: - Total fixed capital required, divided in production unit (ISBL); infrastructure (OSBL) and contingency - Alternative perspective on the total fixed capital, divided in direct costs, indirect costs and contingency - Working capital and costs incurred during industrial plant commissioning and start-up * Production cost, broken down by: - Manufacturing variable costs (raw materials, utilities) - Manufacturing fixed costs (maintenance costs, operating charges, plant overhead, local taxes and insurance) - Depreciation and corporate overhead costs * Raw materials consumption, products generation and labor requirements * Process block flow diagram and description of industrial site installations (production unit and infrastructure) This report was developed based essentially on the following reference(s): (1) US Patent 7186856, issued to Cargill in 2007; (2) US Patent 8883464, issued to Opx Biotechnologies in 2014 Keywords: Dextrose, Anaerobic Fermentation, Salt-Splitting, Acrylic Acid, Tridecylamine
Precision Medicine for Investigators, Practitioners and Providers addresses the needs of investigators by covering the topic as an umbrella concept, from new drug trials to wearable diagnostic devices, and from pediatrics to psychiatry in a manner that is up-to-date and authoritative. Sections include broad coverage of concerning disease groups and ancillary information about techniques, resources and consequences. Moreover, each chapter follows a structured blueprint, so that multiple, essential items are not overlooked. Instead of simply concentrating on a limited number of extensive and pedantic coverages, scholarly diagrams are also included. - Provides a three-pronged approach to precision medicine that is focused on investigators, practitioners and healthcare providers - Covers disease groups and ancillary information about techniques, resources and consequences - Follows a structured blueprint, ensuring essential chapters items are not overlooked
A thorough introduction to the basics of bioengineering, with a focus on applications in the emerging "white" biotechnology industry. As such, this latest volume in the "Advanced Biotechnology" series covers the principles for the design and analysis of industrial bioprocesses as well as the design of bioremediation systems, and several biomedical applications. No fewer than seven chapters introduce stoichiometry, kinetics, thermodynamics and the design of ideal and real bioreactors, illustrated by more than 50 practical examples. Further chapters deal with the tools that enable an understanding of the behavior of cell cultures and enzymatically catalyzed reactions, while others discuss the analysis of cultures at the level of the cell, as well as structural frameworks for the successful scale-up of bioreactions. In addition, a short survey of downstream processing options and the control of bioreactions is given. With contributions from leading experts in industry and academia, this is a comprehensive source of information peer-reviewed by experts in the field.
The present book contains the Proceedings of a two day Symposium on Uremic Toxins organized at the University of Ghent in Belgium. A series of guest lectures, free communications and posters have been presented. An international audience of 163 scientists from 16 nationalities listened to and discussed extensively a spectrum of topics brought forward by colleagues and researchers who worked for many years in the field of Uremic Toxins. There is a striking contrast between all the new dialysis strategies available in the work to "clean" the uremic patients and the almost non-progression of our knowledge on uremic toxins in the past decade. In this sense the symposium was felt by all participants as a new start for the research in the biochemical field of the definition of uremia. If the present volume would stimulate new work in this field in order to define uremia, or identify the uremic toxins, the purpose of the organizers would be maximally fulfilled.
Chemical reaction engineering is at the core of chemical engineering education. Unfortunately, the subject can be intimidating to students, because it requires a heavy dose of mathematics. These mathematics, unless suitably explained in the context of the physical phenomenon, can confuse rather than enlighten students. Bearing this in mind, Reaction Engineering Principles is written primarily from a student’s perspective. It is the culmination of the author’s more than twenty years of experience teaching chemical reaction engineering. The textbook begins by covering the basic building blocks of the subject—stoichiometry, kinetics, and thermodynamics—ensuring students gain a good grasp of the essential concepts before venturing into the world of reactors. The design and performance evaluation of reactors are conveniently grouped into chapters based on an increasing degree of difficulty. Accordingly, isothermal reactors—batch and ideal flow types—are addressed first, followed by non-isothermal reactor operation, non-ideal flow in reactors, and some special reactor types. For better comprehension, detailed derivations are provided for all important mathematical equations. Narrative of the physical context in which the formulae work adds to the clarity of thought. The use of mathematical formulae is elaborated upon in the form of problem solving steps followed by worked examples. Effects of parameters, changing trends, and comparisons between different situations are presented graphically. Self-practice exercises are included at the end of each chapter.
The latest volume in the Advanced Biotechnology series provides an overview of the main production hosts and platform organisms used today as well as promising future cell factories in a two volume book. Alongside describing tools for genetic and metabolic engineering for strain improvement, the authors also impart topical information on computational tools, safety aspects and industrial-scale production. Following an introduction to general concepts, historical developments and future technologies, the text goes on to cover multi-purpose bacterial cell factories, including those organisms that exploit anaerobic biosynthetic power. Further chapters deal with microbes used for the production of high-value natural compounds and those obtained from alternative raw material sources, concluding with eukaryotic workhorses.
A review of the interdisciplinary field of synthetic biology, from genome design to spatial engineering. Written by an international panel of experts, Synthetic Biology draws from various areas of research in biology and engineering and explores the current applications to provide an authoritative overview of this burgeoning field. The text reviews the synthesis of DNA and genome engineering and offers a discussion of the parts and devices that control protein expression and activity. The authors include information on the devices that support spatial engineering, RNA switches and explore the early applications of synthetic biology in protein synthesis, generation of pathway libraries, and immunotherapy. Filled with the most recent research, compelling discussions, and unique perspectives, Synthetic Biology offers an important resource for understanding how this new branch of science can improve on applications for industry or biological research.
