The Viroids
The Viroids

Author: T.O. Diener

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 349

ISBN-13: 1461318556

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More than seven years have passed since the first monograph on viroids was published. At that time, the existence of viroids as a novel type of pathogen far smaller than viruses had been amply demonstrated and some of their unusual molecular properties had been elucidated, but the entry of molecular biology into viroid research was still in its infancy. Since that time, our knowledge of the molecular properties of viroids has increased exponentially and viroids have become even more fasci nating than was the case seven years ago. Today, aside from transfer RNA, viroids are probably the best known type of RNA-at least from a struc tural standpoint. Much less is known of the mechanisms of viroid func tion, such as the exact pathway and enzymology of viroid replication and the biochemistry of viroid pathogenesis. Recently, however, emphasis in viroid research has shifted from structural to functional themes and im portant beginnings have been made in the elucidation of viroid struc ture-function relationships. With the discovery of viroidlike RNAs within the capsids of certain plant viruses and the finding of surprising structural similarities between viroids and plant satellite RNAs, the conceptual gap between viroids and conventional viruses has significantly narrowed. Even beyond virology, connecting links with cellular RNAs have come to light and the long isolation of viroids land "viroidologists"J has come to an end.

Subviral Pathogens of Plants and Animals: Viroids and Prions
Subviral Pathogens of Plants and Animals: Viroids and Prions

Author: Karl Maramorosch

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 565

ISBN-13: 0323145949

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Subviral Pathogens of Plants and Animals: Viroids and Prions is organized into four parts consisting of a total of 20 chapters that discuss the nature of subviral pathogens of plants and animal. This book first elucidates the recognition of subviral pathogens, and then explores the host range of viroids and its diseases. It also addresses the control of viroid diseases. The book explains the structure and replication of viroids. Lastly, it centers on the structure and biology of prions, as well as the diseases these pathogens cause. This treatise will be of considerable scientific interest and importance to those in the field of human and veterinary medicine, virology, zoology, microbiology, plant pathology, entomology, as well as other branches of biology.

Viroids and Satellites
Viroids and Satellites

Author: Karl Maramorosch

Publisher: CRC Press

Published: 1991-09-11

Total Pages: 196

ISBN-13: 9780849367830

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This is an essential bench book that describes the molecular biology, structure, detection, purification, and pathogenesis of viroids and satellites. The volume begins with an overview of the current status of the field, followed by four chapters describing details of methodology, nucleic acid probes, purification, sequence variation, complementary RNA probes, polyacrylamide gel electrophoresis and mutational analysis of viroid movement and pathogenicity. Remaining chapters discuss such topics as viroids that cause apple scar disease in China, the cadang-cadang disease of palms in the Pacific area, viroid-like satellite RNAs, and a comparison of plant viroids with the human-pathogenic delta agent. The book will be a major reference work on viroids for years to come and an essential resource for virologists, molecular biologists, microbiologists, geneticists, biochemists, biomedical investigators, plant pathologists, and agricultural researchers.

Ring Nitrogen and Key Biomolecules
Ring Nitrogen and Key Biomolecules

Author: E.G. Brown

Publisher: Springer Science & Business Media

Published: 1998-07-31

Total Pages: 258

ISBN-13: 9780412835704

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The nitrogen-containing ring structures are at the hub of metabolism and include ATP, nucleic acids, many coenzymes, metabolic regulators and integrators such as adenosine and GTP, signalling compounds such as cyclic nucleotides and plant cytokinins and biochemically functional pigmets of which haemoglobin, the cytochromes and chlorophyll are examples. This important book collates and integrates current knowledge of all the biologically important N-heterocyclic compounds, covering the relationship between their chemical structures and physiological functions within this key group of compounds. Few biochemical reaction sequences do not involve one of these compounds as a substrate, product or coenzyme and a full understanding of the interrelationship between their structure and function is vital for all those woorking in the field of biochemistry. Professor Eric Brown who has a huge wealth of experience in teaching and research on these compounds has written a very comprehensible and thorough book which will be of great value for advanced students and researchers in biochemistry and those at the interfacing subject areas of chemistry, biology and pharmacology including all those employed in researching biological function within pharmaceutical companies.

Molecular Basis of Viral and Microbial Pathogenesis
Molecular Basis of Viral and Microbial Pathogenesis

Author: Rudolf Rott

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 194

ISBN-13: 3642732143

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Elucidation of the mechanisms of pathogenesis underlying the diseases caused by viruses and bacteria has fascinated scientists for many years in two ways. Firstly, these pathogenic agents represent relatively sim ple biological systems for the study of basic biological processes such as replication, gene regulation, genetic variability and host-pathogen interactions. Secondly, process in this field is valuable in a practi cal sence, since it can help in the control of these diseases. The avail ability of new genetic and immunological techniques, especially recom binant DNA methods and monoclonal antibody technology, has provided powerful tools for unravelling the genetic, biochemical and immunologi cal basis of viral and microbial pathogenesis. Molecular cloning has allowed the isolation of single genes or groups of genes related to phenotypes which appear to be immunologically important for pathogene sis. The specific elimination of such genes from the complex genomes of the pathogens can now be achieved with similar genetic techniques. These genetic studies have provided additional information on the role played by specific phenotypic traits in pathogenesis, especially when combined with relevant animal model systems. Furthermore, the struc tural analysis of important virulence factors and surface antigens may allow the prediction of antigenic domains suitable for the development of new vaccines. The 38th Mosbacher Colloquium focuses on the molecular basis of viral and microbial pathogenesis. The virology part begins with the well studied plant viroids. The unusual structure of their genome, as well as knowledge about their replication and pathogenicity, are presented.