Ion Channels

Ion Channels

Author: James N. C. Kew

Publisher:

Published: 2010

Total Pages: 586

ISBN-13: 0199296758

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Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent is often involved, either as the cause or the effect of the illness. Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological functions of ion channels in an attempt to develop novel therapeutic treatments for a wide range of diseases. This book provides a comprehensive overview of ion channel structure and function. It comprises two major parts. Part one is an introductory overview of the ion channel superfamily and the generic aspects of ion channel function. This part also reviews the methodologies by which ion channel function can be studied from the perspective of performing detailed biophysical characterization through to the deployment of high throughput approaches for identifying novel ion channel ligands. Part two of the book provides an in-depth review of the individual ion channel subfamilies and, as such, is subdivided into four broad sections: Voltage-Gated Ion Channels, Extracellular Ligand-Gated Ion Channels, Intracellular Ligand-Gated Ion Channels, and Polymodal-Gated Ion Channels, with each chapter focused on specific family members. These chapters have been written by world leading experts and provide a detailed overview of the structure, biophysics, localization, pharmacology, physiology, and disease relevance of each particular ion channel subfamily. Reviewing both the basic principles of ion channel function and providing a detailed up-to-date review of the phsyiological and pharmacological aspects of individual ion channel sub-families, this book constitutes both an excellent introduction to the field for non-specialists, as well as a highly valuable reference text for experienced researchers already working in the ion channel area.


Ion Channel Factsbook

Ion Channel Factsbook

Author:

Publisher: Academic Press

Published: 1995-11-16

Total Pages: 471

ISBN-13: 0080535194

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How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, sequence information, gene organization? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact? The Academic Press FactsBook series will satisfy scientists and clinical researchers suffering from information overload. Each volume provides a catalogue of the essential properties of families of molecules. Gene organization, sequence information, physicochemical properties, and biological activity are presented using a common, easy to follow format. Taken together they compile everything you wanted to know about proteins but were too busy to look for.In a set of four inter-related volumes, The Ion Channel FactsBook provides a comprehensive framework of facts about channel molecules central to electrical signalling phenomena in living cells. The first volume is devoted to Extracellular Ligand-Gated Integral Receptor-Channel Families including those molecular complexes activated by: 5-Hydroxytryptamine, ATP, Glutamate, Acetylcholine, GABA, Glycine. Nomenclature Expression Sequence analyses Structure and function Electrophysiology Pharmacology Information retrieval


Ion Exchange

Ion Exchange

Author: Friedrich G. Helfferich

Publisher: Courier Corporation

Published: 1995-01-01

Total Pages: 642

ISBN-13: 9780486687841

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Comprehensive text provides sound understanding of the relevant factors in ion exchange and the theoretical tools needed to solve specific problems. Detailed coverage of ion exchangers, equilibria, kinetics, electrochemical properties, ion-exchanger membranes, much more. Each chapter contains helpful summary and references. Accessible to nonmathematical students. Introduction. 1962 edition.


Two Comic Dialogues

Two Comic Dialogues

Author: Plato

Publisher: Hackett Publishing

Published: 1983-01-01

Total Pages: 100

ISBN-13: 9780915145775

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Together these two dialogues contain Plato's most important work on poetry and beauty.


Ion

Ion

Author: Plato

Publisher: tredition

Published: 2022-05-04

Total Pages: 34

ISBN-13: 3347638654

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Ion - Plato - Plato is a Classical Greek philosopher, mathematician, student of Socrates, writer of philosophical dialogues, and founder of the Academy in Athens, the first institution of higher learning in the Western world. Along with his mentor, Socrates, and his student, Aristotle, Plato helped to lay the foundations of Western philosophy and science. Plato is one of the most important Western philosophers, exerting influence on virtually every figure in philosophy after him. His dialogue The Republic is known as the first comprehensive work on political philosophy. Plato also contributed foundationally to ethics, metaphysics, and epistemology. His student, Aristotle, is also an extremely influential philosopher and the tutor of Alexander the Great of Macedonia Plato is widely considered a pivotal figure in the history of Ancient Greek and Western philosophy, along with his teacher, Socrates, and his most famous student, Aristotle. He has often been cited as one of the founders of Western religion and spirituality. The so-called neoplatonism of philosophers, such as Plotinus and Porphyry, greatly influenced Christianity through Church Fathers such as Augustine. Alfred North Whitehead once noted: "the safest general characterization of the European philosophical tradition is that it consists of a series of footnotes to Plato." Plato was an innovator of the written dialogue and dialectic forms in philosophy. Plato is also considered the founder of Western political philosophy. His most famous contribution is the theory of Forms known by pure reason, in which Plato presents a solution to the problem of universals known as Platonism (also ambiguously called either Platonic realism or Platonic idealism). He is also the namesake of Platonic love and the Platonic solids. His own most decisive philosophical influences are usually thought to have been, along with Socrates, the pre-Socratics Pythagoras, Heraclitus and Parmenides, although few of his predecessors' works remain extant and much of what we know about these figures today derives from Plato himself. Unlike the work of nearly all of his contemporaries, Plato's entire body of work is believed to have survived intact for over 2,400 years. Although their popularity has fluctuated, Plato's works have consistently been read and studied. Little can be known about Plato's early life and education due to the very limited accounts. Plato came from one of the wealthiest and most politically active families in Athens. Ancient sources describe him as a bright though modest boy who excelled in his studies. His father contributed everything necessary to give to his son a good education, and Plato therefore must have been instructed in grammar, music, gymnastics and philosophy by some of the most distinguished teachers of his era.


Ion Channels and Disease

Ion Channels and Disease

Author: Frances M. Ashcroft

Publisher: Academic Press

Published: 1999-10-20

Total Pages: 505

ISBN-13: 0080535216

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Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Introduces the relevant aspects of molecular biology and biophysics Describes the principal methods used to study channelopathies Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype


Ion Mobility Spectrometry

Ion Mobility Spectrometry

Author: G.A. Eiceman

Publisher: CRC Press

Published: 2013-12-10

Total Pages: 418

ISBN-13: 1439859981

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Since the turn of the twenty-first century, applications of ion mobility spectrometry (IMS) have diversified, expanding their utility in the military and security spheres and entering the realms of clinical practice and pharmaceutical exploration. Updated and expanded, the third edition of Ion Mobility Spectrometry begins with a comprehensive discu


Ion Exchange Membranes

Ion Exchange Membranes

Author: Toshikatsu Sata

Publisher: Royal Society of Chemistry

Published: 2004

Total Pages: 336

ISBN-13: 9780854045907

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Various separation membranes have been developed since their discovery over half a century ago, providing numerous benefits and fulfilling many applications in our everyday lives. They lend themselves to techniques ranging from microfiltration and gas separation, to what can be considered as the most advanced technique - ion exchange. This book, aimed at academic researchers, engineers and industrialists, contains a brief history of ion exchange and goes on to explain the preparation, characterization, modification and applications of these important membranes. Discussions include the use of ion exchange in analytical and medical techniques, as well as the development of future applications.


Fundamentals of Electric Propulsion

Fundamentals of Electric Propulsion

Author: Dan M. Goebel

Publisher: John Wiley & Sons

Published: 2008-12-22

Total Pages: 528

ISBN-13: 0470436263

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Throughout most of the twentieth century, electric propulsion was considered the technology of the future. Now, the future has arrived. This important new book explains the fundamentals of electric propulsion for spacecraft and describes in detail the physics and characteristics of the two major electric thrusters in use today, ion and Hall thrusters. The authors provide an introduction to plasma physics in order to allow readers to understand the models and derivations used in determining electric thruster performance. They then go on to present detailed explanations of: Thruster principles Ion thruster plasma generators and accelerator grids Hollow cathodes Hall thrusters Ion and Hall thruster plumes Flight ion and Hall thrusters Based largely on research and development performed at the Jet Propulsion Laboratory (JPL) and complemented with scores of tables, figures, homework problems, and references, Fundamentals of Electric Propulsion: Ion and Hall Thrusters is an indispensable textbook for advanced undergraduate and graduate students who are preparing to enter the aerospace industry. It also serves as an equally valuable resource for professional engineers already at work in the field.