Experimental Approaches to Diabetic Retinopathy
Experimental Approaches to Diabetic Retinopathy

Author: H.-P. Hammes

Publisher: Karger Medical and Scientific Publishers

Published: 2010

Total Pages: 241

ISBN-13: 3805592752

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This volume sets the stage for clinical experts working with diabetic patients as well as for researchers by describing the clinical presentations of retinopathy and their anatomical and functional correlates. It reviews currently available experimental models in animals. The impact of retinal pericytes, neuroglia and, specifically, Mller cells are discussed in detail. The volume addresses a variety of current scientific discussions about mechanisms of damage such as growth factors and the VEGF/PEDF balance in the diabetic eye, the ocular renin-angiotensin system, and leukocyte interactions with the microvasculature among others. Stem and progenitor cells in the retina are discussed as potential directions for future investigation. The final chapters return to emerging clinical aspects, including current approaches to retinopathy as a predictor of cardiovascular risk and how knowledge can be translated from bench to bedside. Bridging a widening gap in medical research between basic scientists, who may lose sight of the clinical presentations, and clinical researchers, who may grow unaware of the limits of experimental models, this volume serves as a reference platform for endocrinologists, diabetologists, ophthalmologists, as well as for scientists involved in clinical and basic research in diabetic retinopathy and other vascular complications of diabetes.

Diabetic Retinopathy
Diabetic Retinopathy

Author: Guei-Sheung Liu

Publisher: Springer Nature

Published: 2023-06-16

Total Pages: 223

ISBN-13: 1071632558

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This detailed volume provides various cellular and experimental animal models and research methodologies to understand the complex interrelated pathophysiological mechanisms triggered by hyperglycemia that underlie the development of diabetic retinopathy. The book covers methods for understanding the pathogenesis of diabetic retinopathy, detection and screening of biomarkers in diabetic retinopathy, as well as novel technologies for diabetic retinopathy management. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Diabetic Retinopathy: Methods and Protocols serves as an invaluable resource for scientists and clinicians who are interested in the area of ophthalmology research.

Clinical Strategies in the Management of Diabetic Retinopathy
Clinical Strategies in the Management of Diabetic Retinopathy

Author: Francesco Bandello

Publisher: Springer

Published: 2018-09-17

Total Pages: 300

ISBN-13: 3319961578

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The advent of intravitreal treatment with anti-vascular endothelium growth factor (anti-VEGF) antibodies and steroids has revolutionized the management of diabetic retinopathy. This timely 2nd edition delves into therapies involving anti-VEGF, and addresses the complexities inherent in the practical application of these clinical trials, from issues of patient compliance, to consideration of the patient’s overall health status. Clinical Strategies in the Management of Diabetic Retinopathy: Step-by-Step Guide for Ophthalmologists, 2nd Edition covers all the stages of diabetic retinopathy, including clinical manifestations, imaging, and treatment, from the early signs to more advanced levels of severity. Richly-illustrated, this clinical resource is designed to present multiple practical and useful suggestions for the management of each stage of diabetic retinopathy, using algorithms, tables, and summaries. Images of sample cases exemplify the effects of different therapies, including benefits and side effects. Novel perspectives in both imaging and treatment are provided to clearly outline current research in the field, with a look to future directions. Written and edited by well-respected leaders in the field, Clinical Strategies in the Management of Diabetic Retinopathy, 2nd edition is an ideal resource for ophthalmologists aiming to provide optimal clinical management for this sight-threatening disease.

Early Events in Diabetic Retinopathy and Intervention Strategies
Early Events in Diabetic Retinopathy and Intervention Strategies

Author: Andrew Tsin

Publisher: BoD – Books on Demand

Published: 2018-04-18

Total Pages: 104

ISBN-13: 1789230829

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The development of diabetic retinopathy is a long slow process affected by hyperglycemia, hypertension, lipid levels and genetics. It is expected that in 20 years' duration nearly all those with diabetes will exhibit diabetic retinopathy. In some patients, it will progress to blindness. While the number of individuals with diabetes increases, our current treatments are only effective at advanced levels of disease. Further, our screening methods to detect those needing treatment are currently not optimal. Early Events in Diabetic Retinopathy and Intervention Strategies covers topics addressing imaging processes currently available in the development of diabetic retinopathy screening. Potential biomarkers, that may be used to identify those at risk and illuminate the new pathways which lead to diabetic retinopathy, are expounded.

New Mechanisms of Action of Natural Antioxidants in Health and Disease
New Mechanisms of Action of Natural Antioxidants in Health and Disease

Author: Silvana Hrelia

Publisher: MDPI

Published: 2020-07-03

Total Pages: 168

ISBN-13: 3039362682

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This book contributes to increasing the knowledge on the mechanisms of action of natural antioxidants, evidencing their pleiotropic role in the prevention and/or counteraction of degenerative diseases, and promoting their application in the functional food and cosmetic fields.

Diabetic Retinopathy
Diabetic Retinopathy

Author: Gabriele E. Lang

Publisher: Karger Medical and Scientific Publishers

Published: 2007-01-01

Total Pages: 181

ISBN-13: 3805582439

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Diabetic retinopathy (DR), damage of the blood vessels in the retina, is one of the problems that patients may face as a complication of diabetes and is, along with other diabetic eye diseases, the greatest single cause of blindness in developed countries. This publication starts with the description of the mechanisms of development and progression of diabetic macular edema and with the characterization of the early stages of DR. An innovative approach of multimedial mapping methods which enables to differentiate between three DR phenotypes is further described. The standards and novel approaches of laser treatment as well as current surgical options and treatment techniques are discussed. Additional contributions consider the pathology of diffuse macular edema and the implications for surgery, the treatment of DR with triamcinolone and its complications, and the application of somatostatin analogues. A new therapeutic approach is the use of vascular endothelial growth factor inhibitors in diabetic macular edema. The volume concludes with articles on the latest concepts of posterior vitreous detachment by pharmacologic vitreolysis and the specific protein kinase C subtype ß inhibitor ruboxistaurin mesylate. To ophthalmologists and diabetes health care professionals interested in diabetic eye disease this book is an essential up-date.

Diabetic Retinopathy
Diabetic Retinopathy

Author: Gloria Wu

Publisher: Lippincott Williams & Wilkins

Published: 2010

Total Pages: 272

ISBN-13: 1605476625

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Diabetic Retinopathy: The Essentials is written for general ophthalmologists and optometrists as well as family practitioners, diabetologists, and internists who encounter diabetic patients on a daily basis. It focuses on the diagnosis and management of diabetic retinopathy from the point of view of the retinal specialist. The book begins with the epidemiology, anatomy, and pathophysiology of diabetic retinopathy, and then covers important topics such as classification issues, diagnostic testing, examination techniques, new treatment modalities, patient management, indications for vitrectomy, pregnancy concerns, and informed consent. Coverage includes both general medical issues in diabetes and specifically ophthalmologic concerns. Features include more than 200 full-color photographs, case studies, and algorithms for patient management. A companion website includes the full text online and an image bank.

Diabetic Retinopathy
Diabetic Retinopathy

Author: Michael W. Stewart

Publisher: Springer

Published: 2017-04-07

Total Pages: 278

ISBN-13: 9811035091

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A well-illustrated and comprehensive analysis of the treatment of diabetic retinopathy, this book covers current treatment options and guidelines, whilst also providing a detailed discussion of emerging therapeutic targets. Existing therapeutic options are covered in depth, with a major focus on anti-vascular endothelial growth factor drugs and sustained release corticosteroids, including a review of trial results supporting current treatment guidelines. The use of agents off-label is also discussed. Controversial topics are discussed in detail with an emphasis on helping the reader make informed decisions, particularly when treating patients for which several treatment approaches may be appropriate because trial data does not clearly define the best option. Emerging therapeutic areas are evaluated, as work continues to identify agents that produce superior morphologic responses and visual acuity gains by targeting other molecules that contribute to diabetic retinopathy. Promising new drugs, targets and delivery systems are identified, and their development analysed.

Prevention of Blindness from Diabetes Mellitus
Prevention of Blindness from Diabetes Mellitus

Author: World Health Organization

Publisher: World Health Organization

Published: 2006

Total Pages: 49

ISBN-13: 924154712X

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Diabetes mellitus is an important public health problem worldwide, and more than 75% of patients who have had diabetes mellitus for more than 20 years will have some sort of retinopathy. Diabetic retinopathy correlates with the duration of diabetes; thus with increasing life expectancy, diabetic retinopathy and the ensuing blindness will tend to increase. In view of the increasing prevalence of diabetes mellitus and diabetic retinopathy throughout most of the world, a consultation on prevention of blindness from diabetes mellitus was convened by the World Health Organization to review the current status of diabetic retinopathy care and to define approaches to screening, early detection and management in populations in different settings. This publication reports on the findings of the consultation and provides recommendations and guidelines for the prevention and care of blindness from diabetes mellitus.